Browsing by Author "Skurnik, David"
Now showing items 1-5 of 5
-
A Comprehensive Analysis of In Vitro and In Vivo Genetic Fitness of Pseudomonas aeruginosa Using High-Throughput Sequencing of Transposon Libraries
Skurnik, David; Roux, Damien; Aschard, Hugues; Cattoir, Vincent; Yoder-Himes, Deborah; Lory, Stephen; Pier, Gerald B. (Public Library of Science, 2013)High-throughput sequencing of transposon (Tn) libraries created within entire genomes identifies and quantifies the contribution of individual genes and operons to the fitness of organisms in different environments. We ... -
Covariate selection for association screening in multiphenotype genetic studies
Aschard, Hugues; Guillemot, Vincent; Vilhjalmsson, Bjarni; Patel, Chirag; Skurnik, David; Ye, Chun J; Wolpin, Brian; Kraft, Phillip; Zaitlen, Noah (Springer Science and Business Media LLC, 2017-10-16) -
A Poly-N-Acetylglucosamine−Shiga Toxin Broad-Spectrum Conjugate Vaccine for Shiga Toxin-Producing Escherichia coli
Lu, Xi; Skurnik, David; Pozzi, Clarissa; Roux, Damien; Cywes-Bentley, Colette; Ritchie, Jennifer M.; Munera, Diana; Gening, Marina L.; Tsvetkov, Yury E.; Nifantiev, Nikolay E.; Waldor, Matthew K.; Pier, Gerald B. (American Society of Microbiology, 2014)ABSTRACT Many pathogens produce the β-(1−6)-linked poly-N-acetylglucosamine (PNAG) surface polysaccharide that is being developed as a broadly protective antimicrobial vaccine. However, it is unknown whether systemically ... -
Randomized Controlled Trial of Parent Therapeutic Education on Antibiotics to Improve Parent Satisfaction and Attitudes in a Pediatric Emergency Department
Angoulvant, François; Rouault, Anne; Prot-Labarthe, Sonia; Boizeau, Priscilla; Skurnik, David; Morin, Laurence; Mercier, Jean-Christophe; Alberti, Corinne; Bourdon, Olivier (Public Library of Science, 2013)Objective: To evaluate therapeutic education delivered in a pediatric emergency department to improve parents’ satisfaction and attitudes about judicious antibiotic use. Methods: In an emergency department of a tertiary ... -
Transcriptional Response of Mucoid Pseudomonas aeruginosa to Human Respiratory Mucus
Cattoir, V.; Narasimhan, G.; Skurnik, David; Aschard, Hugues; Roux, Damien; Ramphal, R.; Jyot, J.; Lory, Stephen (American Society of Microbiology, 2012)Adaptation of bacterial pathogens to a host can lead to the selection and accumulation of specific mutations in their genomes with profound effects on the overall physiology and virulence of the organisms. The opportunistic ...