Now showing items 1-1 of 1

    • Continuous Evolution of Base Editors With Expanded Target Compatibility and Improved Activity 

      Zheng, Christine; Wilson, Christopher; Thuronyi, Benjamin; Koblan, Luke; Levy, Jonathan; Yeh, Wei-Hsi; Newby, Gregory; Bhaumik, Mantu; Shubina-Oleinik, Olga; Holt, Jeffrey; Liu, David (Springer Science and Business Media LLC, 2019-07-22)
      Base editors use DNA-modifying enzymes targeted with a catalytically impaired CRISPR protein to precisely install point mutations. Here, we develop phage-assisted continuous evolution of base editors (BE–PACE) to improve ...