Browsing by Author "Baryawno, Ninib"

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    • Amino acid–insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells 

      Kalaitzidis, Demetrios; Lee, Dongjun; Efeyan, Alejo; Kfoury, Youmna Sami; Nayyar, Naema; Sykes, David Brian; Mercier, Francois; Papazian, Ani Elizabeth; Baryawno, Ninib; Victora, Gabriel D.; Neuberg, Donna S.; Sabatini, David Alexander; Scadden, David Thomas (American Society for Clinical Investigation, 2017)
      The mTOR pathway is a critical determinant of cell persistence and growth wherein mTOR complex 1 (mTORC1) mediates a balance between growth factor stimuli and nutrient availability. Amino acids or glucose facilitates mTORC1 ...

    • Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance 

      Wickström, Malin; Dyberg, Cecilia; Milosevic, Jelena; Einvik, Christer; Calero, Raul; Sveinbjörnsson, Baldur; Sandén, Emma; Darabi, Anna; Siesjö, Peter; Kool, Marcel; Kogner, Per; Baryawno, Ninib; Johnsen, John Inge (Nature Pub. Group, 2015)
      The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) is commonly overexpressed in cancers and is implicated in the development of chemoresistance. The use of drugs inhibiting MGMT has been hindered by their ...