Now showing items 1-10 of 10

    • Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes 

      Veiga, Patrick; Gallini, Carey Ann; Beal, C.; Michaud, Monia; Delaney, Mary Louise Rodriguez; DuBois, A.; Khlebnikov, A.; van Hylckama Vlieg, J. E. T.; Punit, S.; Glickman, Jonathan Neil; Onderdonk, Andrew Bruce; Glimcher, Laurie Hollis; Garrett, Wendy S. (Proceedings of the National Academy of Sciences, 2010)
      Intestinal health requires the coexistence of eukaryotic self with the gut microbiota and dysregulated host-microbial interactions can result in intestinal inflammation. Here, we show that colitis improved in T-bet(-/-)Rag2(-/-) ...
    • Calcineurin Regulates Innate Antifungal Immunity in Neutrophils 

      Greenblatt, Matthew Blake; Aliprantis, Antonios O.; Hu, Bella; Glimcher, Laurie Hollis (Rockefeller University Press, 2010)
      Patients taking immunosuppressive drugs, like cyclosporine A (CsA), that inhibit calcineurin are highly susceptible to disseminated fungal infections, although it is unclear how these drugs suppress resistance to these ...
    • Control of T Helper Cell Differentiation through Cytokine Receptor Inclusion in the Immunological Synapse 

      Maldonado, Roberto A.; Soriano, Michelle A.; Perdomo, L. Carolina; Sigrist, Kirsten; Irvine, Darrell J.; Decker, Thomas; Glimcher, Laurie Hollis (The Rockefeller University Press, 2009)
      The antigen recognition interface formed by T helper precursors (Thps) and antigen-presenting cells (APCs), called the immunological synapse (IS), includes receptors and signaling molecules necessary for Thp activation and ...
    • IRE1α Activation Protects Mice Against Acetaminophen-Induced Hepatotoxicity 

      Hur, Kyu Yeon; So, Jae-Seon; Ruda, Vera; Frank-Kamenetsky, Maria; Fitzgerald, Kevin; Koteliansky, Victor; Iwawaki, Takao; Glimcher, Laurie Hollis; Lee, Ann-Hwee (The Rockefeller University Press, 2012)
      Mice lacking the transcription factor XBP1 exhibit constitutive activation of the stress sensor IRE1α and are protected from acetaminophen overdose–induced acute liver failure.
    • A multiple redundant genetic switch locks in the transcriptional signature of T regulatory cells 

      Fu, Wenxian; Ergun, Ayla; Lu, Ting; Hill, Jonathan A.; Haxhinasto, Sokol; Fassett, Marlys S.; Gazit, Roi; Adoro, Stanley; Glimcher, Laurie; Chan, Susan; Kastner, Philippe; Rossi, Derrick; Collins, James J.; Mathis, Diane; Benoist, Christophe (2013)
      The transcription factor FoxP3 partakes dominantly in the specification and function of FoxP3+CD4+ T regulatory cells (Tregs), but is neither strictly necessary nor sufficient to determine the characteristic Treg signature. ...
    • A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy 

      Paez-Cortez, Jesus; Schmitt-Knosalla, Isabela; Mfarrej, Bechara; Donnarumma, Michela; Habicht, Antje; Clarkson, Michael R.; Ansari, M. Javeed; Yuan, Xueli; D'Addio, Francesca; Iacomini, John J.; Glimcher, Laurie Hollis; Sayegh, Mohamed Hassan (The Rockefeller University Press, 2008)
      T-bet plays a crucial role in Th1 development. We investigated the role of T-bet in the development of allograft rejection in an established MHC class II–mismatched (bm12 into B6) model of chronic allograft vasculopathy ...
    • TAK1 is an Essential Regulator of BMP Signalling in Cartilage 

      Shim, Jae-Hyuck; Greenblatt, Matthew Blake; Xie, Min; Schneider, Michael D; Zou, Weigou; Zhai, Bo; Gygi, Steven P.; Glimcher, Laurie Hollis (Nature Publishing Group, 2009)
      TGFβ activated kinase 1 (TAK1), a member of the MAPKKK family, controls diverse functions ranging from innate and adaptive immune system activation to vascular development and apoptosis. To analyse the in vivo function of ...
    • The transcription factor XBP1 is selectively required for eosinophil differentiation 

      Bettigole, Sarah Elizabeth; Lis, Raphael; Adoro, Stanley; Lee, Ann-Hwee; Spencer, Lisa Ann; Weller, Peter Fahey; Glimcher, Laurie Hollis (Nature Publishing Group, 2015)
      The transcription factor XBP1 has been linked to the development of highly secretory tissues such as plasma cells and Paneth cells, yet its function in granulocyte maturation has remained unknown. Here we discovered an ...
    • The Transcription T-bet is Required for Optimal Proinflammatory Trafficking of CD4+ T Cells 

      Rao, RM; Lord, GM; Choe, H.; Lichtman, AH; Luscinskas, FW; Glimcher, Laurie Hollis (BioMed Central, 2005)
      Background: The transcription factor T-bet is a critical regulator of Th1 effector function. Animals deficient in T-bet are protected from a variety of inflammatory diseases, including systemic lupus erythematosus and ...
    • XBP1 Governs Late Events in Plasma Cell Differentiation and Is not Required for Antigen-Specific Memory B Cell Development 

      McHeyzer-Williams, Louise J.; Kowal, Czeslawa; Lee, Ann-Hwee; Volpe, Bruce T.; Diamond, Betty; McHeyzer-Williams, Michael G.; Todd, Derrick James; Glimcher, Laurie Hollis (Rockefeller University Press, 2009)
      The unfolded protein response (UPR) is a stress response pathway that is driven by the increased load of unfolded proteins in the endoplasmic reticulum of highly secretory cells such as plasma cells (PCs). X box binding ...