Browsing by Author "Weihe, Pal"
Now showing items 1-20 of 59
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Application of hair-mercury analysis to determine the impact of a seafood advisory
Weihe, Pal; Grandjean, Philippe; Jørgensen, Poul J. (Elsevier BV, 2005)Following an official recommendation in the Faroe Islands that women should abstain from eating mercury-contaminated pilot whale meat, a survey was carried out to obtain information on dietary habits and hair samples for ... -
Assessment of Xenoestrogenic Exposure by a Biomarker Approach: Application of the E-Screen Bioassay to Determine Estrogenic Response of Serum Extracts
Rasmussen, Thomas Høj; Nielsen, Flemming; Andersen, Helle Raun; Nielsen, Jesper Bo; Weihe, Pal; Grandjean, Philippe (BioMed Central, 2003)Background: Epidemiological documentation of endocrine disruption is complicated by imprecise exposure assessment, especially when exposures are mixed. Even if the estrogenic activity of all compounds were known, the ... -
Association between mercury concentrations in blood and hair in methylmercury-exposed subjects at different ages
Budtz-Jørgensen, Esben; Jørgensen, Poul J; Grandjean, Philippe; Weihe, Pal; Keiding, Niels (Elsevier BV, 2004)Mercury concentrations were measured in paired hair and blood samples from a cohort of about 1000 children examined at birth and at 7 and 14 years of age. The ratio between concentrations in maternal hair (in μg/g) and in ... -
Association between perfluoroalkyl substance exposure and asthma and allergic disease in children as modified by MMR vaccination
Timmermann, Clara Amalie Gade; Budtz-Jørgensen, Esben; Jensen, Tina Kold; Osuna, Christa Elyse; Petersen, Maria Skaalum; Steuerwald, Ulrike; Nielsen, Flemming; Poulsen, Lars K.; Weihe, Pal; Grandjean, Philippe (Informa UK Limited, 2017)Perfluoroalkyl substances (PFAS) are highly persistent chemicals that might be associated with asthma and allergy, but the associations remain unclear. Therefore, this study examined whether pre- and post-natal PFAS exposure ... -
Behavioral difficulties in 7-year old children in relation to developmental exposure to perfluorinated alkyl substances
Oulhote, Youssef; Steuerwald, Ulrike; Debes, Frodi; Weihe, Pal; Grandjean, Philippe (Elsevier BV, 2016)Background: Perfluorinated alkyl substances (PFAS) are suspected endocrine disruptors that are highly persistent and neurotoxic in animals. Human epidemiological studies of exposure-related deviations of children’s behaviors ... -
Benchmark dose calculations of methylmercury-associated neurobehavioural deficits
Budtz-Jørgensen, Esben; Grandjean, Philippe; Keiding, Niels; White, Roberta F; Weihe, Pal (Elsevier BV, 2000)Prenatal methylmercury exposure is associated with neuropsychological deficits in Faroese children at age 7 years. Lower confidence bounds of benchmark doses (BMDLs) have now been calculated. With the cord-blood mercury ... -
Birthweight in a fishing community: significance of essential fatty acids and marine food contaminants
Grandjean, Philippe; Bjerve, Kristian S; Weihe, Pal; Steuerwald, Ulrike (Oxford University Press (OUP), 2001)Background Marine food provides essential fatty acids that are important during pregnancy, but the benefits may be limited at high intakes and by seafood contaminants. Methods In the fishing community of the Faroe Islands, ... -
Breastfeeding as an Exposure Pathway for Perfluorinated Alkylates
Mogensen, Ulla B.; Grandjean, Philippe; Nielsen, Flemming; Weihe, Pal; Budtz-Jørgensen, Esben (American Chemical Society (ACS), 2015)Perfluorinated alkylate substances (PFASs) are widely used and have resulted in human exposures worldwide. PFASs occur in breast milk, and the duration of breastfeeding is associated with serum-PFAS concentrations in ... -
Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls
Petersen, Maria Skaalum; Halling, Jónrit; Damkier, Per; Nielsen, Flemming; Grandjean, Philippe; Weihe, Pal; Brøsen, Kim (Springer Nature, 2006)Objective To investigate the CYP1A2 phenotype distribution in a population with an increased exposure to polychlorinated biphenyls (PCBs) that would likely induce an increased activity of this enzyme. Further, to ... -
Cardiac autonomic activity in methylmercury neurotoxicity: 14-year follow-up of a Faroese birth cohort
Grandjean, Philippe; Murata, Katsuyuki; Budtz-Jørgensen, Esben; Weihe, Pal (Elsevier BV, 2004)Objective To determine whether heart function in childhood is affected by exposure to methylmercury (MeHg) from seafood. Study design Prospective study of a Faroese birth cohort (N = 1022). Examinations at ages 7 ... -
Children’s white blood cell counts in relation to developmental exposures to methylmercury and persistent organic pollutants
Oulhote, Youssef; Shamim, Z.; Kielsen, K.; Weihe, Pal; Grandjean, Philippe; Ryder, L.P.; Heilmann, C. (Elsevier BV, 2017)Background: To explore possible markers of developmental immunotoxicity, we prospectively examined 56 children to determine associations between exposures to mercury and persistent organic pollutants since birth and the ... -
Cognitive deficits at age 22 years associated with prenatal exposure to methylmercury
Debes, Frodi; Weihe, Pal; Grandjean, Philippe (Elsevier BV, 2016)Prenatal exposure to mercury has been associated with adverse effects on child neurodevelopment. The present study aims to determine the extent to which methylmercury-associated cognitive deficits persist into adult age. ... -
Concentrations of Polybrominated Diphenyl Ethers, Polychlorinated Biphenyls, and Polychlorobiphenylols in Serum from Pregnant Faroese Women and Their Children 7 Years Later
Fängström, Britta; Hovander, Lotta; Bignert, Anders; Athanassiadis, Ioannis; Linderholm, Linda; Grandjean, Philippe; Weihe, Pal; Bergman, Åke (American Chemical Society (ACS), 2005)The objective of this study was to assess blood concentrations of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs), and their polychlorobiphenylol (OH-PCB) metabolites in humans with a high seafood ... -
Consequences of exposure measurement error for confounder identification in environmental epidemiology
Budtz-Jørgensen, Esben; Keiding, Niels; Grandjean, Philippe; Weihe, Pal; White, Roberta F (Wiley-Blackwell, 2003)Non-differential measurement error in the exposure variable is known to attenuate the dose–response relationship. The amount of attenuation introduced in a given situation is not only a function of the precision of the ... -
Delayed brainstem auditory evoked potential latencies in 14-year-old children exposed to methylmercury
Murata, Katsuyuki; Weihe, Pal; Budtz-Jørgensen, Esben; Jørgensen, Poul J; Grandjean, Philippe (Elsevier BV, 2004)Objective To determine possible exposure-associated delays in auditory brainstem evoked potential latencies as an objective measure of neurobehavioral toxicity in 14-year-old children with developmental exposure to ... -
Direct Assessment of Cumulative Aryl Hydrocarbon Receptor Agonist Activity in Sera from Experimentally Exposed Mice and Environmentally Exposed Humans
Schlezinger, Jennifer J.; Bernard, Pamela L.; Haas, Amelia; Grandjean, Philippe; Weihe, Pal; Sherr, David H. (National Institute of Environmental Health Sciences, 2009)Background: Aryl hydrocarbon receptor (AhR) ligands adversely affect many biological processes. However, assessment of the significance of human exposures is hampered by an incomplete understanding of how complex mixtures ... -
Early-life exposures to persistent organic pollutants in relation to overweight in preschool children
Karlsen, Martina; Grandjean, Philippe; Weihe, Pal; Steuerwald, Ulrike; Oulhote, Youssef; Valvi, Damaskini (Elsevier BV, 2017)Current knowledge on obesogenic effects of persistent organic pollutants (POPs) is equivocal. We therefore evaluated the associations between early-life POP exposures and body mass index (BMI) in 444 Faroese children born ... -
Effect of seafood mediated PCB exposure on desaturase activity and PUFA profile in Faroese septuagenarians
Tøttenborg, Sandra Søgaard; Choi, Anna; Bjerve, Kristian S.; Weihe, Pal; Grandjean, Philippe (Elsevier BV, 2015)Polychlorinated biphenyl (PCB) exposure may affect serum concentrations of polyunsaturated fatty acids (PUFAs) by inhibiting desaturases Δ5 and Δ6 that drive their synthesis from precursor fatty acids. Such changes in the ... -
Elimination Half-Lives of Polychlorinated Biphenyl Congeners in Children
Grandjean, Philippe; Budtz-Jørgensen, Ebsen; Barr, Dana B.; Needham, Larry L.; Weihe, Pal; Heinzow, Birger (American Chemical Society (ACS), 2008)The elimination kinetics of polychlorinated biphenyls (PCBs) in humans is difficult to assess in observational studies, because PCB exposure is never completely abolished. In a community with high dietary PCB exposures ... -
Estimated exposures to perfluorinated compounds in infancy predict attenuated vaccine antibody concentrations at age 5-years
Grandjean, Philippe; Heilmann, Carsten; Weihe, Pal; Nielsen, Flemming; Mogensen, Ulla B.; Timmermann, Amalie; Budtz-Jørgensen, Esben (Informa UK Limited, 2017)Perfluorinated alkylate substances (PFASs) are highly persistent and may cause immunotoxic effects. PFAS-associated attenuated antibody responses to childhood vaccines may be affected by PFAS exposures during infancy, where ...