Now showing items 1-11 of 11

    • Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer 

      Wei, Shuo; Kozono, Shingo; Kats, Lev; Nechama, Morris; Li, Wenzong; Guarnerio, Jlenia; Luo, Manli; You, Mi-Hyeon; Yao, Yandan; Kondo, Asami; Hu, Hai; Bozkurt, Gunes; Moerke, Nathan J.; Cao, Shugeng; Reschke, Markus; Chen, Chun-Hau; Rego, Eduardo M.; LoCoco, Francesco; Cantley, Lewis; Lee, Tae Ho; Wu, Hao; Zhang, Yan; Pandolfi, Pier Paolo; Zhou, Xiao Zhen; Lu, Kun Ping (2015)
      A common key regulator of oncogenic signaling pathways in multiple tumor types is the unique isomerase Pin1. However, available Pin1 inhibitors lack the required specificity and potency. Using mechanism-based screening, ...
    • Assembly and Regulation of the Inflammasome Governed by a Unified Polymerization Mechanism 

      Lu, Alvin Z. (2016-05-13)
      The innate immune system employs a diverse set of pattern recognition receptors to detect intrinsic and extrinsic danger signals for host protection. Inflammasomes represent an important class of receptors that elicit ...
    • HIV burden in men who have sex with men: a prospective cohort study 2007–2012 

      Jia, Zhongwei; Huang, Xiaojie; Wu, Hao; Zhang, Tong; Li, Ning; Ding, Peipei; Sun, Yixuan; Liu, Zhiying; Wei, Feili; Zhang, Hongwei; Jiao, Yanmei; Ji, Yunxia; Zhang, Yonghong; Guo, Caiping; Li, Wei; Mou, Danlei; Xia, Wei; Li, Zhen; Chen, Dexi; Yan, Huiping; Chen, Xinyue; Zhao, Jinkou; Meyers, Kathrine; Cohen, Ted; Mayer, Kenneth Hugh; Salomon, Joshua A.; Lu, Zuhong; Dye, Christopher (Nature Publishing Group, 2015)
      We conducted a prospective cohort study among HIV-negative MSM aged 18 years or older between 2007 and 2012 in Beijing, China to measure the rates of incident HIV and identify risk factors for infection. Among 5,800 ...
    • Molecular basis of caspase-1 polymerization and its inhibition by a novel capping mechanism 

      Lu, Alvin; Li, Yang; Schmidt, Florian I.; Yin, Qian; Chen, Shuobing; Fu, Tian-Min; Tong, Alexander B.; Ploegh, Hidde L.; Mao, Youdong; Wu, Hao (2016)
      Inflammasomes are cytosolic caspase-1 activation complexes that sense intrinsic and extrinsic danger signals to trigger inflammatory responses and pyroptotic cell death. Homotypic interactions by Pyrin domains (PYD) and ...
    • N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment 

      Soh, Boon-Seng; Buac, Kristina; Xu, Huansheng; Li, Edward; Ng, Shi-Yan; Wu, Hao; Chmielowiec, Jolanta; Jiang, Xin; Bu, Lei; Li, Ronald A; Cowan, Chad; Chien, Kenneth R (Nature Publishing Group, 2014)
      The cardiac progenitor cells (CPCs) in the anterior heart field (AHF) are located in the pharyngeal mesoderm (PM), where they expand, migrate and eventually differentiate into major cell types found in the heart, including ...
    • Negative Allosteric Modulation of mGluR5 Partially Corrects Pathophysiology in a Mouse Model of Rett Syndrome 

      Tao, Jifang; Wu, Hao; Coronado, Amanda A.; de Laittre, Elizabeth; Osterweil, Emily K.; Zhang, Yi; Bear, Mark F. (Society for Neuroscience, 2016)
      Rett syndrome (RTT) is caused by mutations in the gene encoding methyl-CpG binding protein 2 (MECP2), an epigenetic regulator of mRNA transcription. Here, we report a test of the hypothesis of shared pathophysiology of RTT ...
    • Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2 

      Lu, Alvin; Li, Yang; Yin, Qian; Ruan, Jianbin; Yu, Xiong; Egelman, Edward; Wu, Hao (2015)
      Absent in melanoma 2 (AIM2) is an essential cytosolic double-stranded DNA receptor that assembles with the adaptor, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and caspase-1 to ...
    • A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly 

      Schmidt, Florian I.; Lu, Alvin; Chen, Jeff W.; Ruan, Jianbin; Tang, Catherine; Wu, Hao; Ploegh, Hidde L. (The Rockefeller University Press, 2016)
      Myeloid cells assemble inflammasomes in response to infection or cell damage; cytosolic sensors activate pro–caspase-1, indirectly for the most part, via the adaptors ASC and NLRC4. This leads to secretion of proinflammatory ...
    • Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencing 

      Wu, Hao; Wu, Xiaoji; Shen, Li; Zhang, Yi (Nature Publishing Group, 2014)
      Active DNA demethylation in mammals involves TET-mediated iterative oxidation of 5-methylcytosine (5mC)/5-hydroxymethylcytosine (5hmC) and subsequent excision repair of highly oxidized cytosine bases 5-formylcytosine ...
    • Structural Study of the RIPoptosome Core Reveals a Helical Assembly for Kinase Recruitment 

      Jang, Tae-ho; Zheng, Chao; Li, Jixi; Richards, Claire; Hsiao, Yu-Shan; Walz, Thomas; Wu, Hao; Park, Hyun Ho (American Chemical Society, 2014)
      Receptor interaction protein kinase 1 (RIP1) is a molecular cell-fate switch. RIP1, together with Fas-associated protein with death domain (FADD) and caspase-8, forms the RIPoptosome that activates apoptosis. RIP1 also ...
    • The ubiquitin-modifying enzyme A20 restricts the ubiquitination of RIPK3 and protects cells from necroptosis 

      Onizawa, Michio; Oshima, Shigeru; Schulze-Topphoff, Ulf; Oses-Prieto, Juan A; Lu, Timothy; Tavares, Rita; Prodhomme, Thomas; Duong, Bao; Whang, Michael I.; Advincula, Rommel; Agelidis, Alex; Barrera, Julio; Wu, Hao; Burlingame, Alma; Malynn, Barbara A.; Zamvil, Scott S.; Ma, Averil (2015)
      A20 is an anti-inflammatory protein linked to multiple human diseases, however the mechanisms by which A20 prevents inflammatory disease are incompletely defined. We now find that A20 deficient T cells and fibroblasts are ...