Browsing by Author "Nestor, Paul"

Now showing items 1-20 of 51

    • Abnormal Angular Gyrus Asymmetry in Schizophrenia 

      Niznikiewicz, Margaret A.; Donnino, Robert; McCarley, Robert William; Nestor, Paul Gerard; Iosifescu, Daniel V.; O'Donnell, Brian; Levitt, James Jonathan; Shenton, Martha Elizabeth (American Psychiatric Publishing, 2000)
      Objective: Few studies have evaluated the parietal lobe in schizophrenia despite the fact that it has an important role in attention, memory, and language—all functions that have been reported to be abnormal in schizophrenia. ...

    • Abnormal Neural Synchrony in Schizophrenia 

      Spencer, Kevin M.; Nestor, Paul Gerard; Niznikiewicz, Margaret A.; Salisbury, Dean F.; Shenton, Martha Elizabeth; McCarley, Robert William (2003)
      Schizophrenia has been conceptualized as a failure of cognitive integration, and abnormalities in neural circuitry (particularly inhibitory interneurons) have been proposed as a basis for this disorder. We used measures ...

    • Age-related deficits in fronto-temporal connections in schizophrenia: A diffusion tensor imaging study 

      Rosenberger, G.; Kubicki, Marek R.; Nestor, Paul Gerard; Connor, E.; Bushell, G.; Markant, D.; Niznikiewicz, Margaret A.; Westin, Carl-Fredrik; Kikinis, Ron; Jsaykin, A.; Shenton, Martha; Markant, Douglas (Elsevier BV, 2008-07)
      Objective: Impairment of white matter connecting frontal and temporal cortices has been reported in schizophrenia. Yet, not much is known about the effects of age on fibers connecting these brain regions. Using diffusion ...

    • Altered orbitofrontal sulcogyral pattern in schizophrenia 

      Nakamura, M.; Nestor, Paul Gerard; McCarley, Robert William; Levitt, James Jonathan; Hsu, Liangge; Kawashima, T.; Niznikiewicz, Margaret A.; Shenton, Martha Elizabeth (Oxford University Press (OUP), 2007)
      Orbitofrontal alteration in schizophrenia has not been well characterized, likely due to marked anatomical variability. To investigate the presence of such alterations, we evaluated the sulcogyral pattern of this ‘H-shaped’ ...

    • Anterior limb of the internal capsule in schizophrenia: a diffusion tensor tractography study 

      Rosenberger, Gudrun; Nestor, Paul Gerard; Oh, Jungsu S.; Levitt, James Jonathan; Kindleman, Gordon; Bouix, Sylvain; Fitzsimmons, Jennifer J; Niznikiewicz, Margaret A.; Westin, Carl-Fredrik; Kikinis, Ron; McCarley, Robert William; Shenton, Martha Elizabeth; Kubicki, Marek R. (Springer Science + Business Media, 2012)
      Thalamo-cortical feedback loops play a key role in the processing and coordination of processing and integration of perceptual inputs and outputs, and disruption in this connection has long been hypothesized to contribute ...

    • Association Between Reduced Extraversion and Right Posterior Fusiform Gyrus Gray Matter Reduction in Chronic Schizophrenia 

      Onitsuka, Toshiaki; Nestor, Paul Gerard; Gurrera, Ronald Joseph; Shenton, Martha Elizabeth; Kasai, Kiyoto; Frumin, Melissa; Niznikiewicz, Margaret A.; McCarley, Robert William (American Psychiatric Publishing, 2005)
      Objective: The authors examined the association between volume of the fusiform gyrus, a region involved in face processing, and the personality trait of extraversion in patients with schizophrenia. Method: Male patients ...

    • Associative memory in chronic schizophrenia: a computational model 

      Han, S Duke; Nestor, Paul Gerard; Shenton, Martha Elizabeth; Niznikiewicz, Margaret A.; Hannah, Gordon; McCarley, Robert William (Elsevier BV, 2003)
      We developed a computer model to simulate associative memory recall of patients with chronic schizophrenia. Model inputs consisted of words derived from normative data that differed in terms of connectivity and network ...

    • Attentional Control and Intelligence: MRI Orbital Frontal Gray Matter and Neuropsychological Correlates 

      Nestor, Paul G.; Nakamura, Motoaki; Niznikiewicz, Margaret; Levitt, James J.; Newell, Dominick T.; Shenton, Martha E.; McCarley, Robert W. (Hindawi Publishing Corporation, 2015)
      Attentional control is a key function of working memory that is hypothesized to play an important role in psychometric intelligence. To test the neuropsychological underpinnings of this hypothesis, we examined full-scale ...

    • Attentional networks and cingulum bundle in chronic schizophrenia? 

      Nestor, Paul Gerard; Kubicki, Marek R.; Spencer, Kevin M.; Niznikiewicz, Margaret A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2007)
      Thirty patients with chronic schizophrenia and 30 age-matched controls performed the Attention Network Test (ANT). A subset of the patient group (n=18) also had available magnetic resonance diffusion tensor imaging (DTI) ...

    • Cerebral white matter abnormalities and their associations with negative but not positive symptoms of schizophrenia 

      Asami, Takeshi; Hyuk Lee, Sang; Bouix, Sylvain; Rathi, Yogesh; Whitford, Thomas; Niznikiewicz, Margaret A.; Nestor, Paul Gerard; McCarley, Robert William; Shenton, Martha Elizabeth; Kubicki, Marek R. (Elsevier BV, 2014)
      Although diffusion tensor imaging (DTI) studies have reported fractional anisotropy (FA) abnormalities in multiple white matter (WM) regions in schizophrenia, relationship between abnormal FA and negative symptoms has not ...

    • Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study 

      Kubicki, Marek R.; Westin, Carl-Fredrik; Nestor, Paul Gerard; Wible, Cynthia Gayle; Frumin, Melissa; Maier, Stephan Ernst; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2003)
      Background: Evidence suggests that a disruption in limbic system network integrity and, in particular, the cingulate gyrus (CG), may play a role in the pathophysiology of schizophrenia; however, the cingulum bundle (CB), ...

    • Cognitive dysfunction in schizophrenia: unifying basic research and clinical aspects 

      McCarley, Robert William; Niznikiewicz, Margaret A.; Salisbury, Dean F.; Nestor, Paul Gerard; O’Donnell, Brian F.; Hirayasu, Yoshio; Grunze, Heinz; Greene, Robert W.; Shenton, Martha Elizabeth (Springer Science + Business Media, 1999)
      Seeking to unite psychological and biological approaches, this paper links cognitive and cellular hypotheses and data about thought and language abnormalities in schizophrenia. The common thread, it is proposed, is a ...

    • Comparing prefrontal gray and white matter contributions to intelligence and decision making in schizophrenia and healthy controls. 

      Nestor, Paul Gerard; Kubicki, Marek R.; Nakamura, Motoaki; Niznikiewicz, Margaret A.; McCarley, Robert William; Shenton, Martha Elizabeth (American Psychological Association (APA), 2010)
      We examined the relationship between neuropsychological performance and magnetic resonance imaging (MRI) of the orbital frontal cortex (OFC) and diffusion tensor imaging (DTI) of the cingulum bundle (CB) within groups of ...

    • Corpus Callosum Abnormalities and Their Association with Psychotic Symptoms in Patients with Schizophrenia 

      Whitford, Thomas; Kubicki, Marek R.; Schneiderman, Jason S.; O, Lauren J.; King, Rebecca; Alvarado, Jorge L.; Khan, Usman; Markant, Douglas; Nestor, Paul Gerard; Niznikiewicz, Margaret A.; McCarley, Robert William; Westin, Carl-Fredrik; Shenton, Martha Elizabeth (Elsevier BV, 2010)
      Background—Whilst the neuroanatomical underpinnings of the functional brain disconnectivity observed in patients with schizophrenia remain elusive, white matter fiber bundles of the brain are a likely candidate given that ...

    • A diffusion tensor imaging study of the anterior limb of the internal capsule in schizophrenia 

      Levitt, James Jonathan; Kubicki, Marek R.; Nestor, Paul Gerard; Ersner-Hershfield, Hal; Westin, C-F; Alvarado, Jorge L.; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2010)
      Introduction—Frontal-subcortical cognitive and limbic feedback loops modulate higher cognitive functioning. The final step in these feedback loops is the thalamo-cortical projection through the anterior limb of the internal ...

    • Diffusion tractography of the fornix in schizophrenia 

      Fitzsimmons, Jennifer J; Kubicki, Marek R.; Smith, K.; Bushell, G.; Estepar, R. San Jose; Westin, Carl-Fredrik; Nestor, Paul Gerard; Niznikiewicz, Margaret A.; Kikinis, Ron; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2009)
      Background: White matter fiber tracts, especially those interconnecting the frontal and temporal lobes, are likely implicated in pathophysiology of schizophrenia. Very few studies, however, have focused on the fornix, a ...

    • Disruption of function–structure coupling in brain regions sub-serving self monitoring in schizophrenia 

      Araki, Tsuyoshi; Niznikiewicz, Margaret A.; Kawashima, Toshiro; Nestor, Paul Gerard; Shenton, Martha Elizabeth; McCarley, Robert William (Elsevier BV, 2013)
      Deficits in self monitoring are a core feature of cognitive dysfunction in schizophrenia, and may be the basis for disturbances of self and lack of insight, ultimately impacting social functioning. However, the functional ...

    • Dissociable contributions of MRI volume reductions of superior temporal and fusiform gyri to symptoms and neuropsychology in schizophrenia 

      Nestor, Paul Gerard; Onitsuka, Toshiaki; Gurrera, Ronald Joseph; Niznikiewicz, Margaret A.; Frumin, Melissa; Shenton, Martha Elizabeth; McCarley, Robert William (Elsevier BV, 2007)
      We sought to identify the functional correlates of reduced magnetic resonance imaging (MRI) volumes of the superior temporal gyrus (STG) and the fusiform gyrus (FG) in patients with chronic schizophrenia. MRI volumes, ...

    • DTI and MTR abnormalities in schizophrenia: Analysis of white matter integrity 

      Kubicki, Marek R.; Park, H.; Westin, Carl-Fredrik; Nestor, Paul Gerard; Mulkern, Robert Vincent; Maier, Stephan Ernst; Niznikiewicz, Margaret A.; Connor, E.E.; Levitt, James Jonathan; Frumin, Melissa; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2005)
      Diffusion tensor imaging (DTI) studies in schizophrenia demonstrate lower anisotropic diffusion within white matter due either to loss of coherence of white matter fiber tracts, to changes in the number and/or density of ...

    • Early nicotine withdrawal and transdermal nicotine effects on neurocognitive performance in schizophrenia 

      Ahnallen, Christopher G; Nestor, Paul Gerard; Shenton, Martha Elizabeth; McCarley, Robert William; Niznikiewicz, Margaret A. (Elsevier BV, 2008)
      As cigarette smoking prevalence rates approach 90% in schizophrenia, an important emerging question is the role of nicotine in the disease-related disturbance in cognition. We therefore tested a total of 38 male cigarette ...