Now showing items 1-8 of 8

    • Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release 

      Ilyinskii, Petr O.; Roy, Christopher J.; O’Neil, Conlin P.; Browning, Erica A.; Pittet, Lynnelle A.; Altreuter, David H.; Alexis, Frank; Tonti, Elena; Shi, Jinjun; Basto, Pamela A.; Iannacone, Matteo; Radovic-Moreno, Aleksandar F.; Langer, Robert S.; Farokhzad, Omid Cameron; von Andrian, Ulrich H.; Johnston, Lloyd P.M.; Kishimoto, Takashi Kei (Elsevier BV, 2014)
      Augmentation of immunogenicity can be achieved by particulate delivery of an antigen and by its co-administration with an adjuvant. However, many adjuvants initiate strong systemic inflammatory reactions in vivo, leading ...
    • Development of Multinuclear Polymeric Nanoparticles as Robust Protein Nanocarriers 

      Wu, Jun; Kamaly, Nazila; Shi, Jinjun; Zhao, Lili; Xiao, Zeyu; Hollett, Geoffrey; John, Rohit; Ray, Shaunak; Xu, Xiaoyang; Zhang, Xueqing; Kantoff, Philip Wayne; Farokhzad, Omid Cameron (Wiley-Blackwell, 2014)
      One limitation of current biodegradable polymeric nanoparticles is their inability to effectively encapsulate and sustainably release proteins while maintaining protein bioactivity. Here we report the engineering of a ...
    • Differentially Charged Hollow Core/Shell Lipid-Polymer-Lipid Hybrid Nanoparticles for Small Interfering RNA Delivery 

      Shi, Jinjun; Xiao, Zeyu; Votruba, Alexander R.; Vilos, Cristian; Farokhzad, Omid Cameron (Wiley-Blackwell, 2011)
      Speedy delivery: Biodegradable and biocompatible polymers and lipids form hybrid core/shell nanoparticles (see picture, left) that show promising in vitro and in vivo results for delivering siRNA. The unique lipid–polymer–lipid ...
    • DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy 

      Xiao, Zeyu; Ji, Changwei; Shi, Jinjun; Pridgen, Eric M; Frieder, Jillian; Farokhzad, Omid Cameron (WILEY-VCH Verlag, 2012)
      Targeted Cancer Therapy: Inspired by the ability of DNA hybridization, a targeted near-infrared (NIR) light-responsive delivery system has been developed through simple DNA self-assembly (PEG=polyethylene glycol). This ...
    • Emerging nanotechnology approaches for HIV/AIDS treatment and prevention 

      Mamo, Tewodros; Moseman, E Ashley; Kolishetti, Nagesh; Salvador-Morales, Carolina; Shi, Jinjun; Kuritzkes, Daniel Robert; Langer, Robert S.; Andrian, Ulrich von; Farokhzad, Omid Cameron (Future Medicine Ltd, 2010)
      Currently, there is no cure and no preventive vaccine for HIV/AIDS. Combination antiretroviral therapy has dramatically improved treatment, but it has to be taken for a lifetime, has major side effects and is ineffective ...
    • Hybrid lipid–polymer nanoparticles for sustained siRNA delivery and gene silencing 

      Shi, Jinjun; Xu, Yingjie; Xu, Xiaoyang; Zhu, Xi; Pridgen, Eric; Wu, Jun; Votruba, Alexander R.; Swami, Archana; Zetter, Bruce Robert; Farokhzad, Omid Cameron (Elsevier BV, 2014)
      The development of controlled-release nanoparticle (NP) technologies has great potential to further improve the therapeutic efficacy of RNA interference (RNAi), by prolonging the release of small interfering RNA (siRNA) ...
    • A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells 

      Stary, G; Olive, A; Radovic-Moreno, A. F.; Gondek, D.; Alvarez, David; Basto, P. A.; Perro, M.; Vrbanac, V. D.; Tager, Andrew Martin; Shi, Jinjun; Yethon, J. A.; Farokhzad, Omid Cameron; Langer, Robert S.; Starnbach, Michael N.; von Andrian, Ulrich H. (American Association for the Advancement of Science (AAAS), 2015)
      Genital Chlamydia trachomatis (Ct) infection induces protective immunity that depends on interferon-γ producing CD4 T-cells. By contrast, mucosal exposure to ultraviolet light (UV)-inactivated Ct (UV-Ct) generated regulatory ...
    • A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins 

      Choi, Won Il; Kamaly, Nazila; Riol-Blanco, Lorena; Lee, In-Hyun; Wu, Jun; Swami, Archana; Vilos, Cristian; Yameen, Basit; Yu, Mikyung; Shi, Jinjun; Tabas, Ira; von Andrian, Ulrich H.; Jon, Sangyong; Farokhzad, Omid C. (American Chemical Society, 2014)
      Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge ...