Browsing by Author "Yeh, Jennifer"
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Deregulation of SOCS5 suppresses dendritic cell function in chronic lymphocytic leukemia
Toniolo, Patricia A.; Liu, Suhu; Yeh, Jennifer E.; Ye, Darwin Q.; Barbuto, José Alexandre M.; Frank, David A. (Impact Journals LLC, 2016)One cause of morbidity and mortality in chronic lymphocytic leukemia (CLL) is infection, which results from defects in a number of components of the immune system. In particular, dendritic cells (DCs) are functionally ... -
JAK2-STAT5 signaling: A novel mechanism of resistance to targeted PI3K/mTOR inhibition
Yeh, Jennifer E; Toniolo, Patricia A; Frank, David A (Landes Bioscience, 2013)A recent article published by Britschgi et al. in Cancer Cell, “JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer,” describes a ... -
Molecular Modulators of the Oncogenic Transcription Factor STAT3
Yeh, Jennifer E. (2015-04-08)Since the neoplastic phenotype of a cell is largely driven by aberrant gene expression patterns, increasing attention has been focused on transcription factors that regulate critical mediators of tumorigenesis such as ... -
STAT3 Induction of miR-146b Forms a Feedback Loop to Inhibit the NF- B to IL-6 Signaling Axis and STAT3-Driven Cancer Phenotypes
Xiang, Michael; Birkbak, Nicolai Juul; Vafaizadeh, V.; Walker, Sarah Rebecca; Yeh, Jennifer E; Liu, Suhu; Kroll, Yasmin; Boldin, M.; Taganov, K.; Groner, B.; Richardson, Andrea Lynn; Frank, David Alan (American Association for the Advancement of Science (AAAS), 2014)Interleukin-6 (IL-6)–mediated activation of signal transducer and activator of transcription 3 (STAT3) is a mechanism by which chronic inflammation can contribute to cancer and is a common oncogenic event. We discovered a ... -
STAT5 Outcompetes STAT3 To Regulate the Expression of the Oncogenic Transcriptional Modulator BCL6
Walker, Sarah Rebecca; Nelson, E; Yeh, Jennifer E; Pinello, Luca; Yuan, Guocheng; Frank, David Alan (American Society for Microbiology, 2013)Inappropriate activation of the transcription factors STAT3 and STAT5 has been shown to drive cancer pathogenesis through dysregulation of genes involved in cell survival, growth, and differentiation. Although STAT3 and ...