Browsing by Author "Stanton, Robert"
Now showing items 1-3 of 3
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Alterations in Energy/Redox Metabolism Induced by Mitochondrial and Environmental Toxins: A Specific Role for Glucose-6-Phosphate-Dehydrogenase and the Pentose Phosphate Pathway in Paraquat Toxicity
Lei, Shulei; Zavala-Flores, Laura; Garcia-Garcia, Aracely; Nandakumar, Renu; Huang, Yuting; Madayiputhiya, Nandakumar; Stanton, Robert C.; Dodds, Eric D.; Powers, Robert; Franco, Rodrigo (American Chemical Society, 2014)Parkinson’s disease (PD) is a multifactorial disorder with a complex etiology including genetic risk factors, environmental exposures, and aging. While energy failure and oxidative stress have largely been associated with ... -
The early decline in renal function in patients with type 1 diabetes and proteinuria predicts the risk of end stage renal disease
Skupien, Jan; Warram, James H.; Smiles, Adam M.; Niewczas, Monika Anna; Gohda, Tomohito; Pezzolesi, Marcus Guy; Cantarovich, Diego; Stanton, Robert Carl; Krolewski, Andrzej Stefan (2012)The risk of end-stage renal disease (ESRD) remains high in patients with type 1diabetes and proteinuria; however, little is known about the rate of decline in their renal function. To help determine this we enrolled patients ... -
Increasing Glucose 6-Phosphate Dehydrogenase Activity Restores Redox Balance in Vascular Endothelial Cells Exposed to High Glucose
Zhang, Zhaoyun; Yang, Zhihong; Zhu, Bo; Hu, Ji; Liew, Chong-Wee; Leopold, Jane Anne; Handy, Diane Elizabeth; Loscalzo, Joseph; Stanton, Robert Carl; Zhang, Ying-Yi (Public Library of Science, 2012)Previous studies have shown that high glucose increases reactive oxygen species (ROS) in endothelial cells that contributes to vascular dysfunction and atherosclerosis. Accumulation of ROS is due to dysregulated redox ...