Now showing items 1-5 of 5

    • Characterization of Individual Polynucleotide Molecules Using a Membrane Channel 

      Kasianowicz, John J.; Brandin, Eric; Branton, Daniel; Deamer, David W. (National Academy of Sciences of the United States of America, 1996)
      We show that an electric field can drive single-stranded RNA and DNA molecules through a 2.6-nm diameter ion channel in a lipid bilayer membrane. Because the channel diameter can accommodate only a single strand of RNA or ...
    • DNA molecules and configurations in a solid-state nanopore microscope 

      Li, Jiali; Gershow, Marc; Stein, Derek; Brandin, Eric Richard; Golovchenko, Jene Andrew (Nature Publishing Group, 2003)
      A nanometre scale pore in a solid state membrane provides a new way to electronically probe the structure of single linear polymers, including those of biological interest in their native environments. Previous work with ...
    • Optical Absorption of DNA−Carbon Nanotube Structures 

      Hughes, Mary E.; Brandin, Eric Richard; Golovchenko, Jene Andrew (American Chemical Society (ACS), 2007)
      We measured the UV optical absorption of single-stranded DNA bound to single-walled carbon nanotubes (DNA/SWNT). The nucleotide absorbance from DNA/SWNT provides the first experimental confirmation that DNA binds to nanotubes ...
    • Probing Single DNA Molecule Transport Using Fabricated Nanopores 

      Chen, Peng; Gu, Jiajun; Brandin, Eric; Kim, Young-Rok; Wang, Qiaoqiao; Branton, Daniel (American Chemical Society, 2004)
      Nanopores can serve as high throughput, single-molecule sensing devices that provide insight into the distribution of static and dynamic molecular activities, properties, or interactions. We have studied double stranded ...
    • Rapid nanopore discrimination between single polynucleotide molecules 

      Meller, A.; Nivon, L; Brandin, Eric Richard; Golovchenko, Jene Andrew; Branton, Daniel (Proceedings of the National Academy of Sciences, 2000)
      A variety of different DNA polymers were electrophoretically driven through the nanopore of an α-hemolysin channel in a lipid bilayer. Single-channel recording of the translocation duration and current flow during traversal ...