Browsing by Author "Murthy, Venkatesh"

Now showing items 1-20 of 26

    • Activation of raphe nuclei triggers rapid and distinct effects on parallel olfactory bulb output channels 

      Kapoor, Vikrant; Provost, Allison; Agarwal, Prateek; Murthy, Venkatesh N. (2015)
      The serotonergic raphe nuclei are involved in regulating brain states over time-scales of minutes and hours. We examined more rapid effects of serotonergic activation on two classes of principal neurons in the mouse olfactory ...

    • All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins 

      Hochbaum, Daniel R.; Zhao, Yongxin; Farhi, Samouil L.; Klapoetke, Nathan; Werley, Christopher A.; Kapoor, Vikrant; Zou, Peng; Kralj, Joel M.; Maclaurin, Dougal; Smedemark-Margulies, Niklas; Saulnier, Jessica L.; Boulting, Gabriella L.; Straub, Christoph; Cho, Yong Ku; Melkonian, Michael; Wong, Gane Ka-Shu; Harrison, D. Jed; Murthy, Venkatesh N.; Sabatini, Bernardo; Boyden, Edward S.; Campbell, Robert E.; Cohen, Adam E. (2014)
      All-optical electrophysiology—spatially resolved simultaneous optical perturbation and measurement of membrane voltage—would open new vistas in neuroscience research. We evolved two archaerhodopsin-based voltage indicators, ...

    • Analysis and Synthesis in Olfaction 

      Rokni, Dan; Murthy, Venkatesh N. (American Chemical Society, 2014)
      Natural environments contain numerous volatile compounds emanating from a large number of sources, and the survival of many animals depends on their ability to segregate odors of interest within complex odorous scenes. In ...

    • Calcium Dynamics During Fertilization in C. elegans 

      Aravinthan, Samuel; Murthy, Venkatesh N.; Hengartner, Michael O (BioMed Central, 2001)
      Background: Of the animals typically used to study fertilization-induced calcium dynamics, none is as accessible to genetics and molecular biology as the model organism Caenorhabditis elegans. Motivated by the experimental ...

    • Convergent Excitatory Pathways Mediate the Zebrafish Escape Behavior 

      Lacoste, Alix Mary Bénédicte (2015-05-14)
      Scientists have long been fascinated by how anatomical structures in the brain can generate the diversity of behaviors apparent in the animal kingdom. While the ultimate goal of neuroscience is to understand complex brain ...

    • Distinct Spatiotemporal Activity in Principal Neurons of the Mouse Olfactory Bulb in Anesthetized and Awake States 

      Blauvelt, David Gregory; Sato, Tomokazu F.; Wienisch, Martin; Murthy, Venkatesh N. (Frontiers Media S.A., 2013)
      The acquisition of olfactory information and its early processing in mammals are modulated by brain states through sniffing behavior and neural feedback. We imaged the spatiotemporal pattern of odor-evoked activity in a ...

    • Illuminating Vertebrate Olfactory Processing 

      Spors, Hartwig; Albeanu, Dinu Florin; Murthy, Venkatesh N.; Rinberg, Dmitry; Uchida, Naoshige; Wachowiak, Matt; Friedrich, Rainer W. (Society for Neuroscience, 2012)
      The olfactory system encodes information about molecules by spatiotemporal patterns of activity across distributed populations of neurons and extracts information from these patterns to control specific behaviors. Recent ...

    • LED Arrays as Cost Effective and Efficient Light Sources for Widefield Microscopy 

      Albeanu, Dinu F.; Soucy, Edward; Sato, Tomokazu F.; Meister, Markus; Murthy, Venkatesh (Public Library of Science, 2008)
      New developments in fluorophores as well as in detection methods have fueled the rapid growth of optical imaging in the life sciences. Commercial widefield microscopes generally use arc lamps, excitation/emission filters ...

    • Looking Back on the First Year of Neural Systems & Circuits 

      Latham, Peter E; Murthy, Venkatesh N. (BioMed Central, 2012)

    • Molecular Organization of Vomeronasal Chemoreception 

      Isogai, Yoh; Si, Sheng; Pont-Lezica, Lorena; Tan, Taralyn Marie; Kapoor, Vikrant; Murthy, Venkatesh N.; Dulac, Catherine (Nature Publishing Group, 2011)
      The vomeronasal organ (VNO) has a key role in mediating the social and defensive responses of many terrestrial vertebrates to species- and sex-specific chemosignals. More than 250 putative pheromone receptors have been ...

    • Morphological, Physiological and Molecular Classification of Mouse Retinal Ganglion Cells 

      Qiao, Mu (2016-01-15)
      Visual information is conveyed from the retina to the brain through axons of retinal ganglion cells (RGCs). There are >20 different subtypes of RGCs, each of which detects specific features. Classification of RGC subtypes ...

    • Motion Processing in the Larval Zebrafish Tectum 

      Grama, Abhinav Satish (2015-05-14)
      Larval zebrafish are highly visual animals that display a diverse repertoire of visually guided behaviors. Five days after their birth, they start tracking and hunting moving prey, a behavior that likely requires underlying ...

    • Nanowire transistor arrays for mapping neural circuits in acute brain slices 

      Qing, Q.; Pal, S. K.; Tian, B.; Duan, X.; Timko, Brian Paul; Cohen-Karni, T.; Murthy, Venkatesh N.; Lieber, Charles M. (Proceedings of the National Academy of Sciences, 2010)
      Revealing the functional connectivity in natural neuronal networks is central to understanding circuits in the brain. Here, we show that silicon nanowire field-effect transistor (Si NWFET) arrays fabricated on transparent ...

    • Neural Mechanisms Underlying the Establishment of Unimodality in Mouse Primary Visual Cortex 

      Hattori, Ryoma (2016-01-27)
      Early visual cortex, an area classically defined as a purely unisensory cortex, has been suggested to be influenced by non-visual sensory inputs (Wallace et al., 2004; Iurilli et al., 2011; Vasconcelos et al., 2011; ...

    • Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice 

      Li, Ying; Mathis, Alexander; Grewe, Benjamin F.; Osterhout, Jessica A.; Ahanonu, Biafra; Schnitzer, Mark J.; Murthy, Venkatesh; Dulac, Catherine (Elsevier BV, 2017-11)
      The medial amygdala (MeA) plays a critical role in processing species- and sex-specific signals that trigger social and defensive behaviors. However, the principles by which this deep brain structure encodes social information ...

    • An Olfactory Cocktail Party: Figure-Ground Segregation of Odorants in Rodents 

      Rokni, Dan; Hemmelder, Vivian Helena; Kapoor, Vikrant; Murthy, Venkatesh N. (Nature Publishing Group, 2014)
      In odorant-rich environments, animals must be able to detect specific odorants of interest against variable backgrounds. However, studies have found that both humans and rodents are poor at analyzing the components of ...

    • Olfactory cortical neurons read out a relative time code in the olfactory bulb 

      Haddad, Rafi; Lanjuin, Anne; Madisen, Linda; Zeng, Hongkui; Murthy, Venkatesh N.; Uchida, Naoshige (2013)
      Odor stimulation evokes complex spatiotemporal activity in the olfactory bulb, suggesting that the identity of activated neurons as well as the timing of their activity convey information about odors. However, whether and ...

    • Optophysiological Analysis of Associational Circuits in the Olfactory Cortex 

      Hagiwara, Akari; Pal, Sumon K.; Sato, Tomokazu F.; Wienisch, Martin; Murthy, Venkatesh N. (Frontiers Research Foundation, 2012)
      Primary olfactory cortical areas receive direct input from the olfactory bulb, but also have extensive associational connections that have been mainly studied with classical anatomical methods. Here, we shed light on the ...

    • Population imaging at subcellular resolution supports specific and local inhibition by granule cells in the olfactory bulb 

      Wienisch, Martin; Murthy, Venkatesh N. (Nature Publishing Group, 2016)
      Information processing in early sensory regions is modulated by a diverse range of inhibitory interneurons. We sought to elucidate the role of olfactory bulb interneurons called granule cells (GCs) in odor processing by ...

    • Precision and diversity in an odor map on the olfactory bulb 

      Soucy, Edward Richard; Albeanu, Dinu F.; Fantana, Antoniu L.; Murthy, Venkatesh N.; Meister, Markus (Springer Nature, 2009)
      We explored the map of odor space created by glomeruli on the olfactory bulb of both rat and mouse. Identified glomeruli could be matched across animals by their response profile to hundreds of odors. Their layout in ...