Browsing by Author "Ferrone, Cristina"

Now showing items 1-17 of 17

    • Acinar Cystadenoma of the Pancreas 

      Khor, Tze S.; Badizadegan, Kamran; Ferrone, Cristina Rosa; Fernandez-Del Castillo, Carlos F.; Desai, Gaurav S.; Saenz, Adam; Le, Long Phi; Lauwers, Gregory Y.; Deshpande, Vikram (Ovid Technologies (Wolters Kluwer Health), 2012)
      Pancreatic acinar cystadenomas (ACAs) are rare cystic lesions showing acinar differentiation with benign outcome. Although debated, ACAs are favored to be neoplastic and potentially the benign counterpart of acinar ...

    • Blocking the formation of radiation–induced breast cancer stem cells 

      Wang, Yangyang; Li, Wende; Patel, Shalin S.; Cong, Juan; Zhang, Nan; Sabbatino, Francesco; Liu, Xiaoyan; Qi, Yuan; Huang, Peigen; Lee, Hang; Taghian, Alphonse; Li, Jian-Jian; DeLeo, Albert B.; Ferrone, Soldano; Epperly, Michael W.; Ferrone, Cristina R.; Ly, Amy; Brachtel, Elena F.; Wang, Xinhui (Impact Journals LLC, 2014)
      The goal of adjuvant (post-surgery) radiation therapy (RT) for breast cancer (BC) is to eliminate residual cancer cells, leading to better local tumor control and thus improving patient survival. However, radioresistance ...

    • Cystic Papillary Pattern in Pancreatic Ductal Adenocarcinoma 

      Kelly, Paul J.; Shinagare, Shweta; Sainani, Nisha I.; Hong, Xiao; Ferrone, Cristina Rosa; Yilmaz, Omer Hidir; Fernandez-Del Castillo, Carlos F.; Lauwers, Gregory Y.; Deshpande, Vikram (Ovid Technologies (Wolters Kluwer Health), 2012)
      INTRODUCTION: The prototypic pancreatic ductal adenocarcinoma shows small-caliber glands that are placed within an exuberant desmoplastic stromal reaction. A number of histologic patterns have been described, and the ...

    • Does Autoimmune Pancreatitis Increase the Risk of Pancreatic Carcinoma? 

      Gupta, Rajib; Khosroshahi, Arezou; Shinagare, Shweta; Fernandez, Carlos; Ferrone, Cristina Rosa; Lauwers, Gregory Y.; Stone, John H; Deshpande, Vikram (Ovid Technologies (Wolters Kluwer Health), 2013)
      OBJECTIVES: To estimate the risk of malignancy in autoimmune pancreatitis (AIP). METHODS: We examined resected pancreata to compare the prevalence of pancreatic intraepithelial neoplasia (PanIN) in 28 cases of AIP and ...

    • Does the Mechanism of Lymph Node Invasion Affect Survival in Patients with Pancreatic Ductal Adenocarcinoma? 

      Konstantinidis, Ioannis T; Deshpande, Vikram; Hui, Hui; Wargo, Jennifer Ann; Fernandez-Del Castillo, Carlos F.; Thayer, Sarah P.; Androutsopoulos, Vasiliki; Lauwers, Gregory Y.; Warshaw, Andrew Louis; Ferrone, Cristina Rosa (Springer Science + Business Media, 2010)
      Background: Lymph node metastases are prognostically significant in pancreatic ductal adenocarcinoma. Little is known about the significance of direct lymph node invasion. Aim: The aim of this study is to find out whether ...

    • Enhancer Signatures Stratify and Predict Outcomes of Non-Functional Pancreatic Neuroendocrine Tumors 

      Cejas, Paloma; Drier, Yotam; Brosens, Lodewijk A. A.; Deshpande, Vikram; Morsink, Folkert H. M.; Graham, Mindy K.; Valk, Gerlof D.; Vriens, Menno R.; Fernandez-Del Castillo, Carlos; Fabiana Lucia da Silva, Annacarolina; Font-Tello, Alba; Heaphy, Christopher M.; Sicinska, Ewa; Dreijerink, Koen; Epstein, Charles; Conemans, Elfi; Ferrone, Cristina; Adar, Tomer; Bowden, Michaela; Whitton, Holly; Long, Henry; Gaskell, Elizabeth; Shoresh, Noam; Kulke, Matthew; Chung, Daniel; Bernstein, Bradley; Shivdasani, Ramesh (Springer Science and Business Media LLC, 2019-07-01)
      Most pancreatic neuroendocrine tumors (PNETs) do not produce excess hormones and are therefore considered ‘non-functional’. As clinical behaviors vary widely and distant metastases are eventually lethal, biological ...

    • Gallbladder Lesions Identified on Ultrasound. Lessons from the Last 10 Years 

      Konstantinidis, Ioannis T; Bajpai, Surabhi; Kambadakone, Avinash R.; Tanabe, Kenneth Kenji; Berger, David Lawrence; Hui, Hui; Sahani, Dushyant V.; Lauwers, Gregory Y.; Fernandez-Del Castillo, Carlos F.; Warshaw, Andrew Louis; Ferrone, Cristina Rosa (Springer Nature, 2011)
      Background: Possible mass lesions identified on ultrasound (US) of the gallbladder may prompt an aggressive surgical intervention due to the possibility of a malignant neoplasm. Aim: This study aims to utilize a large ...

    • Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway 

      Son, Jaekyoung; Lyssiotis, Costas A.; Ying, Haoqiang; Wang, Xiaoxu; Hua, Sujun; Ligorio, Matteo; Perera, Rushika M.; Ferrone, Cristina R.; Mullarky, Edouard; Shyh-Chang, Ng; Kang, Ya’an; Fleming, Jason B.; Bardeesy, Nabeel; Asara, John M.; Haigis, Marcia C.; DePinho, Ronald A.; Cantley, Lewis C.; Kimmelman, Alec C. (2013)
      Cancer cells exhibit metabolic dependencies that distinguish them from their normal counterparts1. Among these addictions is an increased utilization of the amino acid glutamine (Gln) to fuel anabolic processes2. Indeed, ...

    • High fat diet enhances stemness and tumorigenicity of intestinal progenitors 

      Beyaz, Semir; Mana, Miyeko D.; Roper, Jatin; Kedrin, Dmitriy; Saadatpour, Assieh; Hong, Sue-Jean; Bauer-Rowe, Khristian E.; Xifaras, Michael E.; Akkad, Adam; Arias, Erika; Pinello, Luca; Katz, Yarden; Shinagare, Shweta; Abu-Remaileh, Monther; Mihaylova, Maria M.; Lamming, Dudley W.; Dogum, Rizkullah; Guo, Guoji; Bell, George W.; Selig, Martin; Nielsen, G. Petur; Gupta, Nitin; Ferrone, Cristina R.; Deshpande, Vikram; Yuan, Guo-Cheng; Orkin, Stuart H.; Sabatini, David M.; Yilmaz, Ömer H. (2016)
      Little is known about how pro-obesity diets regulate tissue stem and progenitor cell function. Here we find that high fat diet (HFD)-induced obesity augments the numbers and function of Lgr5+ intestinal stem-cells (ISCs) ...

    • Mutational Profiling Reveals PIK3CA Mutations in Gallbladder Carcinoma 

      Deshpande, Vikram; Nduaguba, Afamefuna Maxwell; Zimmerman, Stephanie M; Kehoe, Sarah M; MacConaill, Laura Eleanor; Lauwers, Gregory Y.; Ferrone, Cristina Rosa; Bardeesy, Nabeel; Zhu, Andrew Xiuxuan; Hezel, Aram F (Springer Science + Business Media, 2011)

    • Pancreatic Ductal Adenocarcinoma 

      Konstantinidis, Ioannis T; Warshaw, Andrew Louis; Allen, Jill; Blaszkowsky, Lawrence Scott; Castillo, Carlos; Deshpande, Vikram; Hong, Theodore Sunki; Kwak, Eunice Lee; Lauwers, Gregory Y.; Ryan, David P.; Wargo, Jennifer Ann; Lillemoe, Keith Douglas; Ferrone, Cristina Rosa (Ovid Technologies (Wolters Kluwer Health), 2013)
      Objective: Patients who undergo an R0 resection of their pancreatic ductal adenocarcinoma (PDAC) have an improved survival compared with patients who undergo an R1 resection. It is unclear whether an R1 resection confers ...

    • Pancreatic Ductal Adenocarcinoma: Long-Term Survival Does Not Equal Cure 

      Ferrone, Cristina Rosa; Pieretti-Vanmarcke, Rafael; Bloom, Jordan P; Hui, Hui; Szymonifka, Jackye; Wargo, Jennifer Ann; Thayer, Sarah P.; Lauwers, Gregory Y.; Deshpande, Vikram; Mino-Kenudson, Mari; Fernandez-Del Castillo, Carlos F.; Lillemoe, Keith Douglas; Warshaw, Andrew Louis (Elsevier BV, 2012)
      Background: Pancreatic ductal adenocarcinoma represents 90% of pancreatic cancers and is an important cause of cancer death in the United States. Operative resection remains as the only treatment providing prolonged survival, ...

    • PDGFRα up-regulation mediated by sonic hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation 

      Sabbatino, Francesco; Wang, Yangyang; Wang, Xinhui; Flaherty, Keith T.; Yu, Ling; Pepin, David; Scognamiglio, Giosue'; Pepe, Stefano; Kirkwood, John M.; Cooper, Zachary A.; Frederick, Dennie T.; Wargo, Jennifer A.; Ferrone, Soldano; Ferrone, Cristina R. (Impact Journals LLC, 2014)
      Control of BRAF(V600E) metastatic melanoma by BRAF inhibitor (BRAF-I) is limited by intrinsic and acquired resistance. Growth factor receptor up-regulation is among the mechanisms underlying BRAF-I resistance of melanoma ...

    • Single-Cell RNA Sequencing Identifies Extracellular Matrix Gene Expression by Pancreatic Circulating Tumor Cells 

      Ting, David T.; Wittner, Ben S.; Ligorio, Matteo; Jordan, Nicole Vincent; Shah, Ajay M.; Miyamoto, David T.; Aceto, Nicola; Bersani, Francesca; Brannigan, Brian W.; Xega, Kristina; Ciciliano, Jordan C.; Zhu, Huili; MacKenzie, Olivia C.; Trautwein, Julie; Arora, Kshitij S.; Shahid, Mohammad; Ellis, Haley L.; Qu, Na; Bardeesy, Nabeel; Rivera, Miguel N.; Deshpande, Vikram; Ferrone, Cristina R.; Kapur, Ravi; Ramaswamy, Sridhar; Shioda, Toshi; Toner, Mehmet; Maheswaran, Shyamala; Haber, Daniel A. (2014)
      SUMMARY Circulating tumor cells (CTCs) are shed from primary tumors into the bloodstream, mediating the hematogenous spread of cancer to distant organs. To define their composition, we compared genome-wide expression ...

    • Subclassification of Autoimmune Pancreatitis: A Histologic Classification With Clinical Significance 

      Deshpande, Vikram; Gupta, Rajib; Sainani, Nisha I.; Sahani, Dushyant V.; Virk, Renu; Ferrone, Cristina Rosa; Khosroshahi, Arezou; Stone, John H; Lauwers, Gregory Y. (Ovid Technologies (Wolters Kluwer Health), 2011)
      Autoimmune pancreatitis (AIP) is a chronic inflammatory disease of the pancreas. Examination of pancreatic resection specimens from patients with AIP has shown that there are 2 subclasses of this disease. However, there ...

    • Transcriptional control of the autophagy-lysosome system in pancreatic cancer 

      Perera, Rushika M.; Stoykova, Svetlana; Nicolay, Brandon N.; Ross, Kenneth N.; Fitamant, Julien; Boukhali, Myriam; Lengrand, Justine; Deshpande, Vikram; Selig, Martin K.; Ferrone, Cristina R.; Settleman, Jeff; Stephanopoulos, Gregory; Dyson, Nicholas J.; Zoncu, Roberto; Ramaswamy, Sridhar; Haas, Wilhelm; Bardeesy, Nabeel (2016)
      Activation of cellular stress response pathways to maintain metabolic homeostasis is emerging as a critical growth and survival mechanism in many cancers1. The pathogenesis of pancreatic ductal adenocarcinoma (PDA) requires ...

    • Trends in Presentation and Survival for Gallbladder Cancer During a Period of More Than 4 Decades 

      Konstantinidis, Ioannis T; Deshpande, Vikram; Genevay, Muriel; Berger, David Lawrence; Fernandez-Del Castillo, Carlos F.; Tanabe, Kenneth Kenji; Hui, Hui; Lauwers, Gregory Y.; Ferrone, Cristina Rosa (American Medical Association (AMA), 2009)
      Objectives: To determine the prevalence of incidentally found cases of gallbladder cancer, the incidence of residual disease at reexploration, and the changes in the mode of presentation, treatment, and survival of patients ...