Now showing items 1-3 of 3

    • Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics 

      Rolland, Morgane; Manocheewa, Siriphan; Lanxon-Cookson, Erinn; Deng, Wenjie; Rousseau, Christine M.; Raugi, Dana N.; Learn, Gerald H.; Maust, Brandon S.; Coovadia, Hoosen; Ndung'u, Thumbi; Heckerman, David E.; Mullins, James I.; Carlson, Jonathan Courtland; Swain, Jabaris; Goulder, Philip J.; Walker, Bruce David; Brander, Christian (Public Library of Science, 2010)
      Background: Despite high potential for HIV-1 genetic variation, the emergence of some mutations is constrained by fitness costs, and may be associated with compensatory amino acid (AA) co-variation. To characterize the ...
    • CD8 T Cell Response and Evolutionary Pressure to HIV-1 Cryptic Epitopes Derived from Antisense Transcription 

      Bansal, Anju; Yan, Jiyu; Akinsiku, Olusimidele T.; Schaefer, Malinda; Sabbaj, Steffanie; Bet, Anne; Levy, David N.; Heath, Sonya; Tang, Jianming; Kaslow, Richard A.; Ndung’u, Thumbi; Heckerman, David; Hunter, Eric; Goepfert, Paul A.; Carlson, Jonathan Courtland; Walker, Bruce David; Goulder, Philip J. (The Rockefeller University Press, 2010)
      Retroviruses pack multiple genes into relatively small genomes by encoding several genes in the same genomic region with overlapping reading frames. Both sense and antisense HIV-1 transcripts contain open reading frames ...
    • Evidence of Differential HLA Class I-Mediated Viral Evolution in Functional and Accessory/Regulatory Genes of HIV-1 

      Brumme, Zabrina L; Brumme, Chanson J; Heckerman, David; Korber, Bette T; Daniels, Marcus; Kadie, Carl; Bhattacharya, Tanmoy; Chui, Celia; Szinger, James; Mo, Theresa; Hogg, Robert S; Montaner, Julio S. G; Frahm, Nicole; Harrigan, P. Richard; Carlson, Jonathan Courtland; Brander, Christian; Walker, Bruce David (Public Library of Science, 2007)
      Despite the formidable mutational capacity and sequence diversity of HIV-1, evidence suggests that viral evolution in response to specific selective pressures follows generally predictable mutational pathways. Population-based ...