Now showing items 1-3 of 3

    • Effect of Phosphodiesterase Inhibition on Insulin Resistance in Obese Individuals 

      Ho, Jennifer E.; Arora, Pankaj; Walford, Geoffrey A.; Ghorbani, Anahita; Guanaga, Derek P.; Dhakal, Bishnu P.; Nathan, Daniel I.; Buys, Emmanuel S.; Florez, Jose C.; Newton‐Cheh, Christopher; Lewis, Gregory D.; Wang, Thomas J. (Blackwell Publishing Ltd, 2014)
      Background: Obesity is associated with cardiometabolic disease, including insulin resistance (IR) and diabetes. Cyclic guanosine monophosphate (cGMP) signaling affects energy balance, IR, and glucose metabolism in experimental ...
    • A pilot, short-term dietary manipulation of branched chain amino acids has modest influence on fasting levels of branched chain amino acids 

      Cavallaro, Nicole Landa; Garry, Jamie; Shi, Xu; Gerszten, Robert E.; Anderson, Ellen J.; Walford, Geoffrey A. (Co-Action Publishing, 2016)
      Background: Elevated fasting levels of branched chain amino acids (BCAAs: valine, isoleucine, leucine) in venous blood are associated with a variety of metabolic impairments, including increased risk of type 2 diabetes ...
    • The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH): Design of a pharmacogenetic Resource for Type 2 Diabetes 

      Walford, Geoffrey A.; Colomo, Natalia; Todd, Jennifer N.; Billings, Liana K.; Fernandez, Marlene; Chamarthi, Bindu; Warner, A. Sofia; Davis, Jaclyn; Littleton, Katherine R.; Hernandez, Alicia M.; Fanelli, Rebecca R.; Lanier, Amelia; Barbato, Corinne; Ackerman, Rachel J.; Khan, Sabina Q.; Bui, Rosa; Garber, Laurel; Stolerman, Elliot S.; Moore, Allan F.; Huang, Chunmei; Kaur, Varinderpal; Harden, Maegan; Taylor, Andrew; Chen, Ling; Manning, Alisa K.; Huang, Paul; Wexler, Deborah; McCarthy, Rita M.; Lo, Janet; Thomas, Melissa K.; Grant, Richard W.; Goldfine, Allison; Hudson, Margo S.; Florez, Jose C. (Public Library of Science, 2015)
      Objective: Genome-wide association studies have uncovered a large number of genetic variants associated with type 2 diabetes or related phenotypes. In many cases the causal gene or polymorphism has not been identified, and ...