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    • Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations 

      Merkle, Florian Tobias; Ghosh, Sulagna; Kamitaki, Nolan; Mitchell, Jana Marie; Avior, Yishai; Mello, Curtis Jay; Kashin, Seva; Mekhoubad, Shila; Ilic, Dusko; Sweetnam, Maura Charlton; Saphier Belfer, Genevieve C; Handsaker, Robert E; Genovese, Giulio; Bar, Shiran; Benvenisty, Nissim; McCarroll, Steven A.; Eggan, Kevin Carl (Springer Nature, 2017)
      Background: Depressive disorders are the second-leading cause of global disability, and an area of increasing focus in international health efforts. We describe a community health worker (CHW) program rolled out in a ...
    • Reprogramming within Hours Following Nuclear Transfer into Mouse but not Human Zygotes 

      Egli, Dieter; Chen, Alice E.; Saphier Belfer, Genevieve C; Ichida, Justin; Fitzgerald, Claire; Go, Kathryn J.; Acevedo, Nicole; Patel, Jay; Baetscher, Manfred; Kearns, William G.; Goland, Robin; Leibel, Rudolph L.; Melton, Douglas A.; Eggan, Kevin Carl (Nature Publishing Group, 2011)
      Fertilized mouse zygotes can reprogram somatic cells to a pluripotent state. Human zygotes might therefore be useful for producing patient-derived pluripotent stem cells. However, logistical, legal and social considerations ...