Browsing by Author "Saito, Takamune"
Now showing items 1-5 of 5
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Caenorhabditis Elegans HIM-18/SLX-4 Interacts with SLX-1 and XPF-1 and Maintains Genomic Integrity in the Germline by Processing Recombination Intermediates
Saito, Takamune; Youds, Jillian L.; Boulton, Simon J.; Colaiácovo, Monica P. (Public Library of Science, 2009)Homologous recombination (HR) is essential for the repair of blocked or collapsed replication forks and for the production of crossovers between homologs that promote accurate meiotic chromosome segregation. Here, we ... -
Crossover recombination mediated by HIM-18/SLX4-associated nucleases
Saito, Takamune T; Colaiácovo, Monica P (Landes Bioscience, 2014)Meiosis is a specialized cell division program that results in the formation of haploid gametes (i.e., sperm and eggs) from diploid parental cells, and is essential for all sexually reproducing organisms. Crossover formation, ... -
A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair
Smogorzewska, Agata; Desetty, Rohini; Saito, Takamune; Schlabach, Michael; Lach, Francis P.; Sowa, Mathew E.; Clark, Alan B.; Kunkel, Thomas A.; Harper, Jeffrey Wade; Colaiacovo, Monica P.; Elledge, Stephen J. (Elsevier BV, 2010)The Fanconi anemia (FA) pathway is responsible for interstrand crosslink repair. At the heart of this pathway is the FANCI-FAND2 (ID) complex, which, upon ubiquitination by the FA core complex, travels to sites of damage ... -
Meiosis Specific Coiled-Coil Proteins in Shizosaccharomyces pombe
Ohtaka, Ayami; Saito, Takamune; Okuzaki, Daisuke; Nojima, Hiroshi (BioMed Central, 2007)Many meiosis-specific proteins in Schizosaccharomyces pombe contain coiled-coil motifs which play essential roles for meiotic progression. For example, the coiled-coil motifs present in Meu13 and Mcp7 are required for their ... -
SLX-1 Is Required for Maintaining Genomic Integrity and Promoting Meiotic Noncrossovers in the Caenorhabditis elegans Germline
Saito, Takamune; Mohideen, Firaz; Meyer, Katherine; Harper, J. Wade; Colaiácovo, Monica P. (Public Library of Science, 2012)Although the SLX4 complex, which includes structure-specific nucleases such as XPF, MUS81, and SLX1, plays important roles in the repair of several kinds of DNA damage, the function of SLX1 in the germline remains unknown. ...