Now showing items 1-15 of 15

    • Altered distribution of mucosal NK cells during HIV infection 

      Sips, Magdalena; Sciaranghella, Gaia; Diefenbach, Thomas; Dugast, Anne-Sophie; Berger, Christoph T.; Liu, Qingquan; Kwon, Douglas; Ghebremichael, Musie; Estes, Jacob D.; Carrington, Mary; Martin, Jeffrey N.; Deeks, Steven G.; Hunt, Peter W.; Alter, Galit (2013)
      The human gut mucosa is a major site of HIV infection and infection-associated pathogenesis. Increasing evidence shows that natural killer (NK) cells play an important role in control of HIV infection but the mechanism(s) ...
    • Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8+ T Cells 

      Brumme, Zabrina L; Anastario, Michael; Cohen, Kristin W; Jolin, Jonathan S; Brumme, Chanson J; Streeck, Hendrik; Meier, Angela; Rosenberg, Eric Scott; Alter, Galit; Allen, Todd; Walker, Bruce David; Altfeld, Marcus (Public Library of Science, 2008)
      Background: Virus-specific CD8+ T lymphocytes play a key role in the initial reduction of peak viremia during acute viral infections, but display signs of increasing dysfunction and exhaustion under conditions of chronic ...
    • Association of HLA-DRB1-restricted CD4+ T cell responses with HIV immune control 

      Ranasinghe, Srinika; Cutler, Sam; Davis, Isaiah; Lu, Richard; Soghoian, Damien Z.; Qi, Ying; Sidney, John; Kranias, Gregory; Flanders, Michael; Lindqvist, Madelene; Kuhl, Bjorn; Alter, Galit; Deeks, Steven G.; Walker, Bruce D.; Gao, Xiaojiang; Sette, Alessandro; Carrington, Mary; Streeck, Hendrik (2013)
      The contribution of HLA class II-restricted CD4+ T cell responses to HIV immune control is poorly defined. Here, we delineated novel peptide-DRB1 restrictions in functional assays and analyzed the host genetic effects of ...
    • CD39 Expression Identifies Terminally Exhausted CD8+ T Cells 

      Gupta, Prakash K.; Godec, Jernej; Wolski, David; Adland, Emily; Yates, Kathleen; Pauken, Kristen E.; Cosgrove, Cormac; Ledderose, Carola; Junger, Wolfgang G.; Robson, Simon C.; Wherry, E. John; Alter, Galit; Goulder, Philip J. R.; Klenerman, Paul; Sharpe, Arlene H.; Lauer, Georg M.; Haining, W. Nicholas (Public Library of Science, 2015)
      Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of exhaustion is important both for identifying and potentially ...
    • Characteristics of the Earliest Cross-Neutralizing Antibody Response to HIV-1 

      Mikell, Iliyana; Sather, D. Noah; Kalams, Spyros A.; Altfeld, Marcus; Alter, Galit; Stamatatos, Leonidas (Public Library of Science, 2011)
      Recent cross-sectional analyses of HIV-1+ plasmas have indicated that broadly cross-reactive neutralizing antibody responses are developed by 10%–30% of HIV-1+ subjects. The timing of the initial development of such ...
    • The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies 

      Sok, Devin; Laserson, Uri; Laserson, Jonathan; Liu, Yi; Vigneault, Francois; Julien, Jean-Philippe; Briney, Bryan; Ramos, Alejandra; Saye, Karen F.; Le, Khoa; Mahan, Alison; Wang, Shenshen; Kardar, Mehran; Yaari, Gur; Walker, Laura M.; Simen, Birgitte B.; St. John, Elizabeth P.; Chan-Hui, Po-Ying; Swiderek, Kristine; Kleinstein, Stephen H.; Alter, Galit; Seaman, Michael S.; Chakraborty, Arup K.; Koller, Daphne; Wilson, Ian A.; Church, George M.; Burton, Dennis R.; Poignard, Pascal (Public Library of Science, 2013)
      Broadly neutralizing HIV antibodies (bnAbs) are typically highly somatically mutated, raising doubts as to whether they can be elicited by vaccination. We used 454 sequencing and designed a novel phylogenetic method to ...
    • HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1 

      Kalife, Elizabeth T; Qi, Ying; Johnston, Mary N; Burgett, Nicole; Swartz, Martha E; Yang, Amy; Rockstroh, Juergen K; Jessen, Heiko; Carrington, Mary; Altfeld, Marcus; Streeck, Hendrik; Lichterfeld, Mathias; Alter, Galit; Yu, Xu; Meier, Angela; Allen, Todd; Rosenberg, Eric Scott; Walker, Bruce David (Public Library of Science, 2006)
      Background: Very little is known about the immunodominance patterns of HIV-1-specific T cell responses during primary HIV-1 infection and the reasons for human lymphocyte antigen (HLA) modulation of disease progression. ...
    • Lack of Protection following Passive Transfer of Polyclonal Highly Functional Low-Dose Non-Neutralizing Antibodies 

      Dugast, Anne-Sophie; Chan, Ying; Hoffner, Michelle; Licht, Anna; Nkolola, Joseph; Li, Hualin; Streeck, Hendrik; Suscovich, Todd J.; Ghebremichael, Musie; Ackerman, Margaret E.; Barouch, Dan H.; Alter, Galit (Public Library of Science, 2014)
      Recent immune correlates analysis from the RV144 vaccine trial has renewed interest in the role of non-neutralizing antibodies in mediating protection from infection. While neutralizing antibodies have proven difficult to ...
    • Loss of CD103+ DCs and Mucosal IL-17+ and IL-22+ Lymphocytes is Associated with Mucosal Damage in SIV Infection 

      Klatt, Nichole R.; Estes, Jacob D.; Sun, Xiaoyong; Ortiz, Alexandra M.; Barber, John S.; Harris, Levelle D.; Cervasi, Barbara; Yokomizo, Lauren K.; Pan, Li; Vinton, Carol L.; Tabb, Brian; Canary, Lauren A.; Dang, Que; Hirsch, Vanessa M.; Alter, Galit; Belkaid, Yasmine; Lifson, Jeffrey D.; Silvestri, Guido; Milner, Joshua D.; Paiardini, Mirko; Haddad, Elias K.; Brenchley, Jason M. (2012)
      HIV/SIV disease progression is associated with multifocal damage to the GI tract epithelial barrier that correlates with microbial translocation and persistent pathological immune activation but the underlying mechanisms ...
    • Machine Learning Methods Enable Predictive Modeling of Antibody Feature:Function Relationships in RV144 Vaccinees 

      Choi, Ickwon; Chung, Amy W.; Suscovich, Todd J.; Rerks-Ngarm, Supachai; Pitisuttithum, Punnee; Nitayaphan, Sorachai; Kaewkungwal, Jaranit; O'Connell, Robert J.; Francis, Donald; Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.; Alter, Galit; Ackerman, Margaret E.; Bailey-Kellogg, Chris (Public Library of Science, 2015)
      The adaptive immune response to vaccination or infection can lead to the production of specific antibodies to neutralize the pathogen or recruit innate immune effector cells for help. The non-neutralizing role of antibodies ...
    • Modest Attenuation of HIV-1 Vpu Alleles Derived from Elite Controller Plasma 

      Chen, Jingyan; Tibroni, Nadine; Sauter, Daniel; Galaski, Johanna; Miura, Toshiyuki; Alter, Galit; Mueller, Birthe; Haller, Claudia; Walker, Bruce D.; Kirchhoff, Frank; Brumme, Zabrina L.; Ueno, Takamasa; Fackler, Oliver T. (Public Library of Science, 2015)
      In the absence of antiretroviral therapy, infection with human immunodeficiency virus type 1 (HIV-1) can typically not be controlled by the infected host and results in the development of acquired immunodeficiency. In rare ...
    • NK Cells in HIV Disease 

      Scully, Eileen; Alter, Galit (Springer US, 2016)
      Natural killer (NK) cells play a critical role in viral immunity. In the setting of HIV infection, epidemiologic and functional evidence support a role for NK cells in both protection from new infection and in viral control. ...
    • P10-01. MHC Class I Chain-related Protein A Shedding in Chronic HIV-1 Infection is Associated with Profound NK Cell Dysfunction 

      Nolting, A; Luteijn, R; Carrington, M; Rihn, S; Toth, I; Faetkenheuer, G; Hartmann, P; Dugast, Anne-Sophie; Kane, Kay Shou-Mei; Jost, Stephanie Rachel; Altfeld, Marcus; Alter, Galit (BioMed Central, 2009)
      Background: Natural killer (NK) cells play a critical role in the host defense against viral infections. However, chronic HIV-1 infection is associated with an accumulation of dysfunctional NK cells that poorly control ...
    • P10-11. NK Cells do not Accumulate at Sites of HIV-Replication but Show Increased Activation 

      Luteijn, Rutger; Nolting, Anne; van Lunzen, Jan; Altfeld, Marcus; Alter, Galit (BioMed Central, 2009)
    • Regulation and Programming of Antibody Effector Function through IgG Glycosylation 

      Mahan, Alison Emilia (2014-10-21)
      Antibodies are the defining characteristic of the humoral immune response. Their functions are diverse, including direct neutralization of pathogens and recruitment of other immune molecules or cells. While most successful ...