Browsing by Author "Chen, Sixun"

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    • Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles 

      Eaton, John K.; Furst, Laura; Ruberto, Richard; Moosmayer, Dieter; Hilpmann, André; Ryan, Matthew J.; Zimmermann, Katja; Cai, Luke L.; Niehues, Michael; Badock, Volker; Kramm, Anneke; Chen, Sixun; Hillig, Roman C.; Clemons, Paul; Gradl, Stefan; Montagnon, Claire; Lazarski, Kiel E.; Christian, Sven; Bajrami, Besnik; Neuhaus, Roland; Eheim, Ashley L.; Viswanathan, Vasanthi S; Schreiber, Stuart L (Springer Science and Business Media LLC, 2020-03-30)
      We recently described glutathione peroxidase 4 (GPX4) as a promising target for killing therapy-resistant cancer cells via ferroptosis. The onset of therapy resistance by multiple types of treatment results in a stable ...