Now showing items 1-6 of 6

    • Acrolein exposure suppresses antigen-induced pulmonary inflammation 

      Spiess, Page C; Kasahara, David; Habibovic, Aida; Hristova, Milena; Randall, Matthew J; Poynter, Matthew E; van der Vliet, Albert (BioMed Central, 2013)
      Background: Adverse health effects of tobacco smoke arise partly from its influence on innate and adaptive immune responses, leading to impaired innate immunity and host defense. The impact of smoking on allergic asthma ...
    • Impact of Adiponectin Overexpression on Allergic Airways Responses in Mice 

      Verbout, Norah G.; Benedito, Leandro; Williams, Alison S.; Kasahara, David I.; Wurmbrand, Allison P.; Si, Huiqing; Halayko, Andrew J.; Hug, Christopher; Shore, Stephanie A. (Hindawi Publishing Corporation, 2013)
      Obesity is an important risk factor for asthma. Obese individuals have decreased circulating adiponectin, an adipose-derived hormone with anti-inflammatory properties. We hypothesized that transgenic overexpression of ...
    • Role of the Adiponectin Binding Protein, T-Cadherin (Cdh13), in Allergic Airways Responses in Mice 

      Williams, Alison S.; Kasahara, David I.; Verbout, Norah G.; Fedulov, Alexey V.; Zhu, Ming; Si, Huiqing; Wurmbrand, Allison Patricia; Hug, Christopher; Ranscht, Barbara; Shore, Stephanie Ann (Public Library of Science, 2012)
      Adiponectin is an adipose derived hormone that declines in obesity. We have previously shown that exogenous administration of adiponectin reduces allergic airways responses in mice. T-cadherin (T-cad; Cdh13) is a binding ...
    • Role of the Adiponectin Binding Protein, T-Cadherin (cdh13), in Pulmonary Responses to Subacute Ozone 

      Kasahara, David I.; Williams, Alison S.; Benedito, Leandro A.; Ranscht, Barbara; Kobzik, Lester; Hug, Christopher; Shore, Stephanie A. (Public Library of Science, 2013)
      Adiponectin, an adipose derived hormone with pleiotropic functions, binds to several proteins, including T-cadherin. We have previously reported that adiponectin deficient (Adipo−/−) mice have increased IL-17A-dependent ...
    • γδ T Cells Are Required for M2 Macrophage Polarization and Resolution of Ozone-Induced Pulmonary Inflammation in Mice 

      Mathews, Joel A.; Kasahara, David I.; Ribeiro, Luiza; Wurmbrand, Allison P.; Ninin, Fernanda M. C.; Shore, Stephanie A. (Public Library of Science, 2015)
      We examined the role of γδ T cells in the induction of alternatively activated M2 macrophages and the resolution of inflammation after ozone exposure. Wildtype (WT) mice and mice deficient in γδ T cells (TCRδ-/- mice) were ...
    • γδ T Cells Are Required for Pulmonary IL-17A Expression after Ozone Exposure in Mice: Role of TNFα 

      Mathews, Joel A.; Williams, Alison S.; Brand, Jeffrey D.; Wurmbrand, Allison P.; Chen, Lucas; Ninin, Fernanda MC.; Si, Huiqing; Kasahara, David I.; Shore, Stephanie A. (Public Library of Science, 2014)
      Ozone is an air pollutant that causes pulmonary symptoms. In mice, ozone exposure causes pulmonary injury and increases bronchoalveolar lavage macrophages and neutrophils. We have shown that IL-17A is important in the ...