Now showing items 1-20 of 58

    • The Aromatase Gene (CYP19A1) Variants and Circulating Hepatocyte Growth Factor in Postmenopausal Women 

      Lin, Jennifer H.; Gunter, Marc J.; Manson, JoAnn Elisabeth; Rexrode, Kathryn Marian; Cook, Nancy Romanowicz; Kraft, Peter; Cochrane, Barbara B.; Chlebowski, Rowan T.; Ho, Gloria Y. F.; Zhang, Shumin (Public Library of Science, 2012)
      Background: Estrogen and androgen have been linked to the regulation of circulating hepatocyte growth factor (HGF), an adipose tissue-derived cytokine. It is possible that the CYP19A1 gene which alters sex hormones production ...
    • Association of N-Linked Glycoprotein Acetyls and Colorectal Cancer Incidence and Mortality 

      Chandler, Paulette D.; Akinkuolie, Akintunde O.; Tobias, Deirdre K.; Lawler, Patrick R.; Li, Chungying; Moorthy, M. Vinayaga; Wang, Lu; Duprez, Daniel A.; Jacobs, David R.; Glynn, Robert J.; Otvos, James; Connelly, Margery A.; Post, Wendy S.; Ridker, Paul M.; Manson, JoAnn E.; Buring, Julie E.; Lee, I-Min; Mora, Samia (Public Library of Science, 2016)
      Background: Acute phase proteins highlight the dynamic interaction between inflammation and oncogenesis. GlycA, a novel nuclear magnetic resonance (NMR) inflammatory marker that identifies primarily circulating N-acetyl ...
    • Associations between retinol-binding protein 4 and cardiometabolic risk factors and subclinical atherosclerosis in recently postmenopausal women: cross-sectional analyses from the KEEPS study 

      Huang, Gary; Wang, Dan; Khan, Unab I; Zeb, Irfan; Manson, JoAnn Elisabeth; Miller, Virginia; Hodis, Howard N; Budoff, Matthew J; Merriam, George R; Harman, Mitchell S; Brinton, Eliot A; Cedars, Marcelle I; Su, Yali; Lobo, Rogerio A; Naftolin, Frederick; Santoro, Nanette; Taylor, Hugh S; Wildman, Rachel P (BioMed Central, 2012)
      Background: The published literature regarding the relationships between retinol-binding protein 4 (RBP4) and cardiometabolic risk factors and subclinical atherosclerosis is conflicting, likely due, in part, to limitations ...
    • Birth weight and later life adherence to unhealthy lifestyles in predicting type 2 diabetes: prospective cohort study 

      Li, Yanping; Ley, Sylvia H; Tobias, Deirdre K; Chiuve, Stephanie E; VanderWeele, Tyler J; Rich-Edwards, Janet W; Curhan, Gary C; Willett, Walter C; Manson, JoAnn E; Hu, Frank B; Qi, Lu (BMJ Publishing Group Ltd., 2015)
      Objectives To prospectively assess the joint association of birth weight and established lifestyle risk factors in adulthood with incident type 2 diabetes and to quantitatively decompose the attributing effects to birth ...
    • Body-Mass Index and Mortality among Adults with Incident Type 2 Diabetes 

      Tobias, Deirdre Kay; Pan, An; Jackson, Chandra L.; O'Reilly, Eilis J.; Ding, Eric L.; Willett, Walter C.; Manson, JoAnn E.; Hu, Frank B. (New England Journal of Medicine (NEJM/MMS), 2014)
      Background: The relation between body weight and mortality among persons with type 2 diabetes remains unresolved, with some studies suggesting decreased mortality among overweight or obese persons as compared with normal-weight ...
    • Characterization of Vascular Disease Risk in Postmenopausal Women and Its Association with Cognitive Performance 

      Dowling, N. Maritza; Gleason, Carey E.; Manson, JoAnn E.; Hodis, Howard N.; Miller, Virginia M.; Brinton, Eliot A.; Neal-Perry, Genevieve; Santoro, M. Nanette; Cedars, Marcelle; Lobo, Rogerio; Merriam, George R.; Wharton, Whitney; Naftolin, Frederick; Taylor, Hugh; Harman, S. Mitchell; Asthana, Sanjay (Public Library of Science, 2013)
      Objectives: While global measures of cardiovascular (CV) risk are used to guide prevention and treatment decisions, these estimates fail to account for the considerable interindividual variability in pre-clinical risk ...
    • Chocolate-candy consumption and three-year weight gain among postmenopausal U.S. women 

      Greenberg, James A.; Manson, JoAnn E.; Buijsse, Brian; Wang, Lu; Allison, Matthew A.; Neuhouser, Marian L.; Tinker, Lesley; Waring, Molly E.; Isasi, Carmen R.; Martin, Lisa W.; Thomson, Cynthia A. (2014)
      OBJECTIVE To test the hypothesis that greater chocolate-candy intake is associated with more weight gain in postmenopausal women. DESIGN AND METHODS Prospective cohort study involving 107,243 post-menopausal American women ...
    • Circulating Levels of Resistin and Risk of Type 2 Diabetes in Men and Women: Results from Two Prospective Cohorts 

      Chen, Brian H.; Song, Yiqing; Ding, Eric L.; Roberts, Christian K.; Manson, JoAnn Elisabeth; Rifai, Nader; Buring, Julie Elizabeth; Gaziano, John Michael; Liu, Simin (American Diabetes Association, 2009)
      OBJECTIVE—The purpose of this study was to investigate the role of circulating resistin levels in the development of type 2 diabetes using two prospective cohorts of well-characterized men and women. RESEARCH DESIGN AND ...
    • Coffee and Caffeine Consumption in Relation to Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Postmenopausal Women 

      Goto, Atsushi; Song, Yiqing; Chen, Brian H.; Manson, JoAnn Elisabeth; Buring, Julie Elizabeth; Liu, Simin (American Diabetes Association, 2011)
      OBJECTIVE: Coffee consumption has been inversely associated with type 2 diabetes risk, but its mechanisms are largely unknown. We aimed to examine whether plasma levels of sex hormones and sex hormone–binding globulin ...
    • Common Genetic Variants of the Ion Channel Transient Receptor Potential Membrane Melastatin 6 and 7 (TRPM6 and TRPM7), Magnesium Intake, and Risk of Type 2 Diabetes in Women 

      Song, Yiqing; Hsu, Yi Hsiang; Niu, Tianhua; Manson, JoAnn Elisabeth; Buring, Julie Elizabeth; Liu, Simin (BioMed Central, 2009)
      Background: Ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7) play a central role in magnesium homeostasis, which is critical for maintaining glucose and insulin metabolism. However, ...
    • Comparison of Self-Reported and Accelerometer-Assessed Physical Activity in Older Women 

      Shiroma, Eric J.; Cook, Nancy R.; Manson, JoAnn E.; Buring, Julie E.; Rimm, Eric B.; Lee, I-Min (Public Library of Science, 2015)
      Background: Self-reported physical activity measures continue to be validated against accelerometers; however, the absence of standardized, accelerometer moderate-to-vigorous physical activity (MVPA) definitions has made ...
    • Consistent Directions of Effect for Established Type 2 Diabetes Risk Variants Across Populations: The Population Architecture using Genomics and Epidemiology (PAGE) Consortium 

      Haiman, Christopher A.; Fesinmeyer, Megan D.; Spencer, Kylee L.; Bůžková, Petra; Voruganti, V. Saroja; Wan, Peggy; Haessler, Jeff; Franceschini, Nora; Monroe, Kristine R.; Howard, Barbara V.; Jackson, Rebecca D.; Florez, Jose C.; Kolonel, Laurence N.; Buyske, Steven; Goodloe, Robert J.; Liu, Simin; Manson, JoAnn E.; Meigs, James B.; Waters, Kevin; Mukamal, Kenneth J.; Pendergrass, Sarah A.; Shrader, Peter; Wilkens, Lynne R.; Hindorff, Lucia A.; Ambite, Jose Luis; North, Kari E.; Peters, Ulrike; Crawford, Dana C.; Le Marchand, Loic; Pankow, James S. (American Diabetes Association, 2012)
      Common genetic risk variants for type 2 diabetes (T2D) have primarily been identified in populations of European and Asian ancestry. We tested whether the direction of association with 20 T2D risk variants generalizes ...
    • Consumption of soy foods and isoflavones and risk of type 2 diabetes: a pooled analysis of three US cohorts 

      Ding, Ming; Pan, An; Manson, JoAnn E.; Willett, Walter C.; Malik, Vasanti; Rosner, Bernard; Giovannucci, Edward; Hu, Frank B.; Sun, Qi (2016)
      Background: Evidence regarding the consumption of soy foods and isoflavones in relation to risk of type 2 diabetes (T2D) is scarce. Objective: Our study was to evaluate the association between soy food and isoflavone ...
    • Dairy consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis 

      Chen, Mu; Sun, Qi; Giovannucci, Edward; Mozaffarian, Dariush; Manson, JoAnn E; Willett, Walter C; Hu, Frank B (BioMed Central, 2014)
      Background: The relation between consumption of different types of dairy and risk of type 2 diabetes (T2D) remains uncertain. Therefore, we aimed to evaluate the association between total dairy and individual types of dairy ...
    • Determinants of Racial/Ethnic Disparities in Incidence of Diabetes in Postmenopausal Women in the U.S.: The Women’s Health Initiative 1993–2009 

      Ma, Yunsheng; Hébert, James R.; Manson, JoAnn E.; Balasubramanian, Raji; Liu, Simin; Lamonte, Michael J.; Bird, Chloe E.; Ockene, Judith K.; Qiao, Yongxia; Olendzki, Barbara; Schneider, Kristin L.; Rosal, Milagros C.; Sepavich, Deidre M.; Wactawski-Wende, Jean; Stefanick, Marcia L.; Phillips, Lawrence S.; Ockene, Ira S.; Kaplan, Robert C.; Sarto, Gloria E.; Garcia, Lorena; Howard, Barbara V. (American Diabetes Association, 2012)
      OBJECTIVE To examine determinants of racial/ethnic differences in diabetes incidence among postmenopausal women participating in the Women’s Health Initiative. RESEARCH DESIGN AND METHODS Data on race/ethnicity, baseline ...
    • Dietary and Plasma Magnesium and Risk of Coronary Heart Disease Among Women 

      Chiuve, Stephanie Elizabeth; Sun, Qi; Curhan, Gary Craig; Taylor, Eric N.; Spiegelman, Donna Lynn; Willett, Walter C.; Manson, JoAnn Elisabeth; Rexrode, Kathryn Marian; Albert, Christine Marie (Blackwell Publishing Ltd, 2013)
      Background: Magnesium is associated with lower risk of sudden cardiac death, possibly through antiarrhythmic mechanisms. Magnesium influences endothelial function, inflammation, blood pressure, and diabetes, but a direct ...
    • DNA Methylation Variants at HIF3A Locus, B-Vitamin Intake, and Long-term Weight Change: Gene-Diet Interactions in Two U.S. Cohorts 

      Huang, Tao; Zheng, Yan; Qi, Qibin; Xu, Min; Ley, Sylvia H.; Li, Yanping; Kang, Jae H.; Wiggs, Janey; Pasquale, Louis R.; Chan, Andrew T.; Rimm, Eric B.; Hunter, David J.; Manson, JoAnn E.; Willett, Walter C.; Hu, Frank B.; Qi, Lu (American Diabetes Association, 2015)
      The first epigenome-wide association study of BMI identified DNA methylation at an HIF3A locus associated with BMI. We tested the hypothesis that DNA methylation variants are associated with BMI according to intake of B ...
    • DNA methylation-based measures of biological age: meta-analysis predicting time to death 

      Chen, Brian H.; Marioni, Riccardo E.; Colicino, Elena; Peters, Marjolein J.; Ward-Caviness, Cavin K.; Tsai, Pei-Chien; Roetker, Nicholas S.; Just, Allan C.; Demerath, Ellen W.; Guan, Weihua; Bressler, Jan; Fornage, Myriam; Studenski, Stephanie; Vandiver, Amy R.; Moore, Ann Zenobia; Tanaka, Toshiko; Kiel, Douglas P.; Liang, Liming; Vokonas, Pantel; Schwartz, Joel; Lunetta, Kathryn L.; Murabito, Joanne M.; Bandinelli, Stefania; Hernandez, Dena G.; Melzer, David; Nalls, Michael; Pilling, Luke C.; Price, Timothy R.; Singleton, Andrew B.; Gieger, Christian; Holle, Rolf; Kretschmer, Anja; Kronenberg, Florian; Kunze, Sonja; Linseisen, Jakob; Meisinger, Christine; Rathmann, Wolfgang; Waldenberger, Melanie; Visscher, Peter M.; Shah, Sonia; Wray, Naomi R.; McRae, Allan F.; Franco, Oscar H.; Hofman, Albert; Uitterlinden, André G.; Absher, Devin; Assimes, Themistocles; Levine, Morgan E.; Lu, Ake T.; Tsao, Philip S.; Hou, Lifang; Manson, JoAnn E.; Carty, Cara L.; LaCroix, Andrea Z.; Reiner, Alexander P.; Spector, Tim D.; Feinberg, Andrew P.; Levy, Daniel; Baccarelli, Andrea; van Meurs, Joyce; Bell, Jordana T.; Peters, Annette; Deary, Ian J.; Pankow, James S.; Ferrucci, Luigi; Horvath, Steve (Impact Journals LLC, 2016)
      Estimates of biological age based on DNA methylation patterns, often referred to as “epigenetic age”, “DNAm age”, have been shown to be robust biomarkers of age in humans. We previously demonstrated that independent of ...
    • Effect of Homocysteine-Lowering Treatment With Folic Acid and B Vitamins on Risk of Type 2 Diabetes in Women 

      Song, Yiqing; Cook, Nancy Romanowicz; Albert, Christine Marie; Van Denburgh, Martin; Manson, JoAnn Elisabeth (American Diabetes Association, 2009)
      OBJECTIVE: Homocysteinemia may play an etiologic role in the pathogenesis of type 2 diabetes by promoting oxidative stress, systemic inflammation, and endothelial dysfunction. We investigated whether homocysteine-lowering ...
    • Effect of Low-Fat vs. Other Diet Interventions on Long-Term Weight Change in Adults: A Systematic Review and Meta-Analysis 

      Tobias, Deirdre K.; Chen, Mu; Manson, JoAnn E.; Ludwig, David S.; Willett, Walter; Hu, Frank B. (2015)
      Background: The effectiveness of low-fat diets for long-term weight loss has been debated for decades, with dozens of randomized trials (RCTs) and recent reviews giving mixed results. Methods: We conducted a random effects ...