Browsing by Author "Wilk, Jemma"

Now showing items 1-7 of 7

    • Association between adiponectin and heart failure risk in the Physicians' Health Study 

      Djoussé, Luc; Wilk, Jemma B.; Hanson, Naomi Q.; Glynn, Robert; Tsai, Michael Y.; Gaziano, J. Michael (2012)
      Limited data are available on the association between adiponectin and incident heart failure. In the current ancillary study to the Physicians' Health Study, we used a prospective nested-case control design to examine ...

    • Asthma-susceptibility variants identified using probands in case-control and family-based analyses 

      Murphy, Amy J; Soto-Quiros, Manuel E; Avila, Lydiana; Celedón, Juan C; O'Connor, George T; Himes, Blanca Elena; Su, Jessica Ann Lasky; Wu, Ann Chen; Wilk, Jemma B; Hunninghake, Gary Matthew; Klanderman, Barbara Jordan; Lazarus, Ross; Lange, Christoph; Raby, Benjamin Alexander; Silverman, Edwin Kepner; Weiss, Scott Tillman (BioMed Central, 2010)
      Background: Asthma is a chronic respiratory disease whose genetic basis has been explored for over two decades, most recently via genome-wide association studies. We sought to find asthma-susceptibility variants by using ...

    • A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study 

      Granada, Mark; Wilk, Jemma; Tuzova, Marina; Strachan, David P.; Weidinger, Stephan; Albrecht, Eva; Gieger, Christian; Heinrich, Joachim; Himes, Blanca; Hunninghake, Gary Matthew; Celedón, Juan C.; Weiss, Scott Tillman; Cruikshank, William W.; Farrer, Lindsay A.; Center, David M.; O'Connor, George T. (Elsevier BV, 2012)
      Background— Atopy and plasma IgE concentration are genetically complex traits, and the specific genetic risk factors that lead to IgE dysregulation and clinical atopy are an area of active investigation. Objective— To ...

    • A Genome-Wide Association Study of Pulmonary Function Measures in the Framingham Heart Study 

      Walter, Robert E.; Nagle, Michael W.; Brandler, Brian J.; Borecki, Ingrid B.; O'Connor, George T.; McCarthy, Mark I.; Wilk, Jemma B; Chen, Ting-Hsu; Gottlieb, Daniel J; Myers, Richard Hepworth; Silverman, Edwin Kepner; Weiss, Scott Tillman (Public Library of Science, 2009)
      The ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) is a measure used to diagnose airflow obstruction and is highly heritable. We performed a genome-wide association study in 7,691 ...

    • Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function 

      Hancock, Dana B.; Artigas, María Soler; Gharib, Sina A.; Henry, Amanda; Manichaikul, Ani; Ramasamy, Adaikalavan; Loth, Daan W.; Imboden, Medea; Koch, Beate; McArdle, Wendy L.; Smith, Albert V.; Smolonska, Joanna; Sood, Akshay; Tang, Wenbo; Zhai, Guangju; Burkart, Kristin M.; Curjuric, Ivan; Eijgelsheim, Mark; Elliott, Paul; Gu, Xiangjun; Harris, Tamara B.; Janson, Christer; Homuth, Georg; Hysi, Pirro G.; Loehr, Laura R.; Lohman, Kurt; Loos, Ruth J. F.; Marciante, Kristin D.; Obeidat, Ma'en; Postma, Dirkje S.; Aldrich, Melinda C.; Brusselle, Guy G.; Eiriksdottir, Gudny; Franceschini, Nora; Heinrich, Joachim; Rotter, Jerome I.; Wijmenga, Cisca; Bentley, Amy R.; Laurie, Cathy C.; Lumley, Thomas; Morrison, Alanna C.; Joubert, Bonnie R.; Rivadeneira, Fernando; Couper, David J.; Kritchevsky, Stephen B.; Liu, Yongmei; Wjst, Matthias; Wain, Louise V.; Vonk, Judith M.; Uitterlinden, André G.; Rochat, Thierry; Rich, Stephen S.; Psaty, Bruce M.; O'Connor, George T.; North, Kari E.; Mirel, Daniel B.; Meibohm, Bernd; Launer, Lenore J.; Khaw, Kay-Tee; Hartikainen, Anna-Liisa; Hammond, Christopher J.; Gläser, Sven; Marchini, Jonathan; Wareham, Nicholas J.; Völzke, Henry; Stricker, Bruno H. C.; Spector, Timothy D.; Probst-Hensch, Nicole M.; Jarvis, Deborah; Jarvelin, Marjo-Riitta; Heckbert, Susan R.; Gudnason, Vilmundur; Boezen, H. Marike; Barr, R. Graham; Cassano, Patricia A.; Strachan, David P.; Fornage, Myriam; Hall, Ian P.; Dupuis, Josée; Tobin, Martin D.; London, Stephanie J.; Wilk, Jemma B; Zhao, Jing Hua; Aschard, Hugues; Liu, Jason Z.; Manning, Alisa K; Chen, Ting-Hsu; Williams, O. Dale; Kraft, Phillip L.; Hofman, Albert (Public Library of Science, 2012)
      Genome-wide association studies have identified numerous genetic loci for spirometic measures of pulmonary function, forced expiratory volume in one second \((FEV_1)\), and its ratio to forced vital capacity \((FEV_1/FVC)\). ...

    • On the Analysis of Genome-Wide Association Studies in Family-Based Designs: A Universal, Robust Analysis Approach and an Application to Four Genome-Wide Association Studies 

      Won, Sungho; Wilk, Jemma B; Mathias, Rasika A.; O'Donnell, Christopher Joseph; Silverman, Edwin Kepner; Barnes, Kathleen; O'Connor, George T.; Weiss, Scott Tillman; Lange, Christoph (Public Library of Science, 2009)
      For genome-wide association studies in family-based designs, we propose a new, universally applicable approach. The new test statistic exploits all available information about the association, while, by virtue of its design, ...

    • Opportunities and Challenges in the Genetics of COPD 2010: An International COPD Genetics Conference Report 

      Agusti, Alvar; Anderson, Wayne; Bakke, Per S; Barnes, Kathleen C; Barr, R Graham; Bleecker, Eugene R; Boezen, H Marike; Burkart, Kristin M; Cookson, William OC; Croxton, Thomas; Daley, Denise; Gan, Weiniu; Garcia-Aymerich, Judith; Hall, Ian P; Hansel, Nadia N; Kalsheker, Noor; Kiley, James P; Lambrechts, Diether; Lee, Sang-Do; Lomas, David A; London, Stephanie J; Nishimura, Masaharu; Postma, Dirkje S; Puhan, Milo A; Tesfaigzi, Yohannes; Tobin, Martin D; Vogelmeier, Claus; Wouters, Emiel; Ziegler-Heitbrock, Loems; MacNee, William; Crapo, James D; Vestbo, Jørgen; Silverman, Edwin Kepner; Cho, Michael Hyosang; Celli, Bartolome R; Demeo, Dawn Lisa; Hersh, Craig Palmer; Wilk, Jemma B; Nørdestgaard, Borge G.; Young, Robert P.; O'Donnell, Christopher J.; Kim, Woo Jin; Litonjua, Augusto Ampil (Informa Healthcare, 2011)