Now showing items 1-3 of 3

    • Controlled Ultrasound-Induced Blood-Brain Barrier Disruption Using Passive Acoustic Emissions Monitoring 

      Arvanitis, Costas D.; Livingstone, Margaret Stratford; Vykhodtseva, Natalia I.; McDannold, Nathan Judson (Public Library of Science, 2012)
      The ability of ultrasonically-induced oscillations of circulating microbubbles to permeabilize vascular barriers such as the blood-brain barrier (BBB) holds great promise for noninvasive targeted drug delivery. A major ...
    • Targeted and Reversible Blood-Retinal Barrier Disruption via Focused Ultrasound and Microbubbles 

      Park, Juyoung; Zhang, Yongzhi; Vykhodtseva, Natalia I.; Akula, James Daniel; McDannold, Nathan Judson (Public Library of Science, 2012)
      The blood-retinal barrier (BRB) prevents most systemically-administered drugs from reaching the retina. This study investigated whether burst ultrasound applied with a circulating microbubble agent can disrupt the BRB, ...
    • Targeted, noninvasive blockade of cortical neuronal activity 

      McDannold, Nathan; Zhang, Yongzhi; Power, Chanikarn; Arvanitis, Costas D.; Vykhodtseva, Natalia; Livingstone, Margaret (Nature Publishing Group, 2015)
      Here we describe a novel method to noninvasively modulate targeted brain areas through the temporary disruption of the blood-brain barrier (BBB) via focused ultrasound, enabling focal delivery of a neuroactive substance. ...