Now showing items 1-11 of 11

    • Altered Metabolism in Cancer 

      Locasale, Jason Wei; Cantley, Lewis C. (BioMed Central, 2010)
      Cancer cells have different metabolic requirements from their normal counterparts. Understanding the consequences of this differential metabolism requires a detailed understanding of glucose metabolism and its relation to ...
    • Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis 

      Locasale, J.; Grassian, Alexandra; Beroukhim, Rameen; Meyerson, Matthew Langer; Wagner, Gerhard; Asara, John M.; Brugge, Joan S.; Vander Heiden, Matthew George; Cantley, Lewis C. (BioMed Central, 2012)
    • Decoding Key Nodes in the Metabolism of Cancer Cells: Sugar & Spice and All Things Nice 

      Shaw, Reuben J.; Cantley, Lewis C. (Faculty of 1000 Ltd., 2012)
      In the past 5 years, a convergence of studies has resulted in a broad appreciation in the cancer research community that reprogramming of cellular metabolism may be more central to cancer than appreciated in the past 30 ...
    • Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin 

      Leissring, Malcolm A.; Malito, Enrico; Hedouin, Sabrine; Reinstatler, Lael; Sahara, Tomoko; Abdul-Hay, Samer O.; Choudhry, Shakeel; Maharvi, Ghulam M.; Fauq, Abdul H.; Huzarska, Malwina; May, Philip S.; Logan, Todd P.; Turk, Benjamin E.; Manolopoulou, Marika; Tang, Wei-Jen; Stein, Ross L.; Choi, Sungwoon; Cantley, Lewis C.; Cuny, Gregory Douglas; Selkoe, Dennis J. (Public Library of Science, 2010)
      Background: Insulin is a vital peptide hormone that is a central regulator of glucose homeostasis, and impairments in insulin signaling cause diabetes mellitus. In principle, it should be possible to enhance the activity ...
    • Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε 

      Hutti, Jessica E.; Porter, Melissa A.; Cheely, Adam W.; Cantley, Lewis C.; Wang, Xiaodong; Kireev, Dmitri; Baldwin, Albert S.; Janzen, William P. (Public Library of Science, 2012)
      IKKε and TBK1 are noncanonical IKK family members which regulate inflammatory signaling pathways and also play important roles in oncogenesis. However, few inhibitors of these kinases have been identified. While the substrate ...
    • Discovery of Catalytically Active Orthologues of the Parkinson's Disease Kinase PINK1: Analysis of Substrate Specificity and Impact of Mutations 

      Woodroof, Helen I.; Pogson, Joe H.; Begley, Mike; Cantley, Lewis C.; Deak, Maria; Campbell, David G.; van Aalten, Daan M. F.; Whitworth, Alexander J.; Alessi, Dario R.; Muqit, Miratul M. K. (The Royal Society, 2011)
      Missense mutations of the phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) gene cause autosomal-recessive Parkinson's disease. To date, little is known about the intrinsic catalytic properties of PINK1 since ...
    • Hem-1 Complexes Are Essential for Rac Activation, Actin Polymerization, and Myosin Regulation during Neutrophil Chemotaxis 

      Weiner, Orion D; Rentel, Maike C; Ott, Alex; Bourne, Henry R; Schliwa, Manfred; Brown, Glenn E.; Jedrychowski, Mark P.; Yaffe, Michael Bruce; Gygi, Steven P.; Cantley, Lewis C.; Kirschner, Marc W. (Public Library of Science, 2006)
      Migrating cells need to make different actin assemblies at the cell's leading and trailing edges and to maintain physical separation of signals for these assemblies. This asymmetric control of activities represents one ...
    • A Homogeneous, High-Throughput Assay for Phosphatidylinositol 5-Phosphate 4-Kinase with a Novel, Rapid Substrate Preparation 

      Davis, Mindy I.; Sasaki, Atsuo T.; Shen, Min; Emerling, Brooke M.; Thorne, Natasha; Michael, Sam; Pragani, Rajan; Boxer, Matthew; Sumita, Kazutaka; Takeuchi, Koh; Auld, Douglas S.; Li, Zhuyin; Cantley, Lewis C.; Simeonov, Anton (Public Library of Science, 2013)
      Phosphoinositide kinases regulate diverse cellular functions and are important targets for therapeutic development for diseases, such as diabetes and cancer. Preparation of the lipid substrate is crucial for the development ...
    • PI 3-kinase and disease 

      Cantley, Lewis C. (BioMed Central, 2012)
    • Regulation of Stem Cell Metabolism by the Lin28/let-7 Axis 

      Ng, Shyh Chang (2014-02-25)
      My PhD thesis is focused on two fundamental aspects of stem cell metabolism: (1) the role of Lin28 in programming stem cell metabolism, and (2) how metabolism in turn fuels and governs pluripotency. Our studies led us to ...
    • Somatic Mutations of PIK3R1 Promote Gliomagenesis 

      Quayle, Steven N.; Cheung, Lydia W T.; Wiedemeyer, Ruprecht; Dewan, Robert W.; Huang-Hobbs, Emmet; Zhuang, Li; Mills, Gordon B.; Chin, Lynda; Lee, Jennifer Y.; Ding, Li; Wilson, Richard K.; Ligon, Keith Lloyd; Cantley, Lewis C. (Public Library of Science, 2012)
      The phosphoinositide 3-kinase (PI3K) pathway is targeted for frequent alteration in glioblastoma (GBM) and is one of the core GBM pathways defined by The Cancer Genome Atlas. Somatic mutations of PIK3R1 are observed in ...