Browsing by Author "Lencer, Wayne"

Now showing items 1-14 of 14

    • 4-Phenylbutyrate Attenuates the ER Stress Response and Cyclic AMP Accumulation in DYT1 Dystonia Cell Models 

      Cho, Jin A.; Zhang, Xuan; Miller, Gregory M.; Lencer, Wayne I.; Nery, Flavia C. (Public Library of Science, 2014)
      Dystonia is a neurological disorder in which sustained muscle contractions induce twisting and repetitive movements or abnormal posturing. DYT1 early-onset primary dystonia is the most common form of hereditary dystonia ...

    • The Cdc42 inhibitor secramine B prevents cAMP-induced K+ conductance in intestinal epithelial cells 

      Pelish, Henry Efrem; Ciesla, William; Tanaka, Nori; Reddy, Krishna Podditur; Shair, Matthew David; Kirchhausen, Tomas Leopold; Lencer, Wayne Isaac (Elsevier BV, 2006)
      Cyclic AMP- (cAMP) and calcium-dependent agonists stimulate chloride secretion through the coordinated activation of distinct apical and basolateral membrane channels and ion transporters in mucosal epithelial cells. Defects ...

    • CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types 

      Nelms, Bradlee D.; Waldron, Levi; Barrera, Luis A.; Weflen, Andrew W.; Goettel, Jeremy A.; Guo, Guoji; Montgomery, Robert K.; Neutra, Marian R.; Breault, David T.; Snapper, Scott B.; Orkin, Stuart H.; Bulyk, Martha L.; Huttenhower, Curtis; Lencer, Wayne I. (BioMed Central, 2016)
      We present a sensitive approach to predict genes expressed selectively in specific cell types, by searching publicly available expression data for genes with a similar expression profile to known cell-specific markers. Our ...

    • Congenital chloride-losing diarrhea in a Mexican child with the novel homozygous SLC26A3 mutation G393W 

      Reimold, Fabian R.; Balasubramanian, Savithri; Doroquez, David B.; Shmukler, Boris E.; Zsengeller, Zsuzsanna K.; Saslowsky, David; Thiagarajah, Jay R.; Stillman, Isaac E.; Lencer, Wayne I.; Wu, Bai-Lin; Villalpando-Carrion, Salvador; Alper, Seth L. (Frontiers Media S.A., 2015)
      Congenital chloride diarrhea is an autosomal recessive disease caused by mutations in the intestinal lumenal membrane Cl−/HCO−3 exchanger, SLC26A3. We report here the novel SLC26A3 mutation G393W in a Mexican child, the ...

    • Electrophysiological Studies into the Safety of the Anti-diarrheal Drug Clotrimazole during Oral Rehydration Therapy 

      Lexmond, Willem S.; Rufo, Paul A.; Fiebiger, Edda; Lencer, Wayne I. (Public Library of Science, 2015)
      Background and Aims Morbidity and mortality from acute diarrheal disease remains high, particularly in developing countries and in cases of natural or man-made disasters. Previous work has shown that the small molecule ...

    • Functional Analysis of VopF Activity Required for Colonization in Vibrio cholerae 

      Tam, Vincent C.; Suzuki, Masato; Coughlin, Margaret; Saslowsky, David; Biswas, Kuntal; Lencer, Wayne Isaac; Faruque, Shah M.; Mekalanos, John J. (American Society of Microbiology, 2010)
      Vibrio cholerae, a Gram-negative facultative pathogen, is the etiologic agent for the diarrheal disease cholera. We previously characterized a clinical isolate, AM-19226, that translocates a type III secretion system (T3SS) ...

    • Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins 

      Cho, JinAh; Chinnapen, Daniel Jean-Francois; Aamar, Emil; te Welscher, Yvonne Maria; Lencer, Wayne Isaac; Massol, Ramiro (Frontiers Media S.A., 2012)
      Some bacterial toxins and viruses have evolved the capacity to bind mammalian glycosphingolipids to gain access to the cell interior, where they can co-opt the endogenous mechanisms of cellular trafficking and protein ...

    • Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion 

      Saslowsky, David E.; Thiagarajah, Jay R.; McCormick, Beth A.; Lee, Jean C.; Lencer, Wayne I. (The American Society for Cell Biology, 2016)
      The apical brush border membrane (BBM) of intestinal epithelial cells forms a highly structured and dynamic environmental interface that serves to regulate cellular physiology and block invasion by intestinal microbes and ...

    • Microtubule Motors Power Plasma Membrane Tubulation in Clathrin-Independent Endocytosis 

      Day, Charles A.; Baetz, Nicholas W.; Copeland, Courtney A.; Kraft, Lewis J.; Han, Bing; Tiwari, Ajit; Drake, Kimberly R.; De Luca, Heidi; Chinnapen, Daniel J.-F.; Davidson, Michael W.; Holmes, Randall K.; Jobling, Michael G.; Schroer, Trina A.; Lencer, Wayne I.; Kenworthy, Anne K. (2015)
      How the plasma membrane is bent to accommodate clathrin-independent endocytosis remains uncertain. Recent studies suggest Shiga and cholera toxin induce membrane curvature required for their uptake into clathrin-independent ...

    • Neonatal Fc Receptor Expression in Dendritic Cells Mediates Protective Immunity against Colorectal Cancer 

      Baker, Kristi; Rath, Timo; Flak, Magdalena Barbara; Arthur, Janelle C.; Chen, Zhangguo; Glickman, Jonathan Neil; Zlobec, Inti; Karamitopoulou, Eva; Stachler, Matthew Daniel; Odze, Robert D.; Lencer, Wayne Isaac; Jobin, Christian; Blumberg, Richard Steven (Elsevier BV, 2013)
      Cancers arising in mucosal tissues account for a disproportionately large fraction of malignancies. Immunoglobulin G (IgG) and the neonatal Fc receptor for IgG (FcRn) have an important function in the mucosal immune system ...

    • Neonatal Fc Receptor: From Immunity to Therapeutics 

      Kuo, Timothy Ting-Chang; Baker, Kristi Dorothy; Yoshida, Masaru; Qiao, Shuo-Wang; Aveson, Victoria G.; Lencer, Wayne Isaac; Blumberg, Richard Steven (Springer US, 2010)
      The neonatal Fc receptor (FcRn), also known as the Brambell receptor and encoded by Fcgrt, is a MHC class I like molecule that functions to protect IgG and albumin from catabolism, mediates transport of IgG across epithelial ...

    • Novel Functions for XBP1 and IRE1α in Hematopoiesis 

      Bettigole, Sarah E. (2015-05-20)
      The endoplasmic reticulum (ER) is a critical regulator of cellular homeostasis, primarily responsible for handling calcium storage and signaling, lipid synthesis, and the proper glycosylation and folding of nascent ...

    • The Recycling and Transcytotic Pathways for IgG Transport by FcRn are Distinct and Display an Inherent Polarity 

      Tzaban, Salit; Massol, Ramiro; Yen, Elizabeth Hechavarria; Hamman, Wendy; Frank, Scott Randy; Lapierre, Lynne A.; Hansen, Steen Henning; Goldenring, James R.; Blumberg, Richard Steven; Lencer, Wayne Isaac (Rockefeller University Press, 2009)
      The Fc receptor FcRn traffics immunoglobulin G (IgG) in both directions across polarized epithelial cells that line mucosal surfaces, contributing to host defense. We show that FcRn traffics IgG from either apical or ...

    • TorsinA participates in endoplasmic reticulum-associated degradation 

      Nery, Flávia C.; Armata, Ioanna A.; Farley, Jonathan E.; Cho, JinAh; Yaqub, Uzma; Chen, Pan; da Hora, Cintia Carla; Wang, Qiuyan; Tagaya, Mitsuo; Klein, Christine; Tannous, Bakhos A.; Caldwell, Kim A.; Caldwell, Guy A.; Lencer, Wayne I.; Ye, Yihong; Breakefield, Xandra Owens (Nature Publishing Group, 2012)
      TorsinA is an \(AAA^+\) ATPase located within the lumen of the endoplasmic reticulum and nuclear envelope, with a mutant form causing early onset torsion dystonia (DYT1). Here we report a new function for torsinA in ...