Browsing by Author "Kasper, Dennis"

Now showing items 1-11 of 11

    • A branched chain amino acid metabolite drives vascular transport of fat and causes insulin resistance 

      Jang, Cholsoon; Oh, Sungwhan F; Wada, Shogo; Rowe, Glenn C; Liu, Laura; Chan, Mun Chun; Rhee, James; Hoshino, Atsushi; Kim, Boa; Ibrahim, Ayon; Baca, Luisa G; Kim, Esl; Ghosh, Chandra C; Parikh, Samir M; Jiang, Aihua; Chu, Qingwei; Forman, Daniel E.; Lecker, Stewart H.; Krishnaiah, Saikumari; Rabinowitz, Joshua D; Weljie, Aalim M; Baur, Joseph A; Kasper, Dennis L; Arany, Zoltan (2016)
      Epidemiological and experimental data implicate branched chain amino acids (BCAAs) in the development of insulin resistance, but the mechanisms underlying this link remain unclear.1–3 Insulin resistance in skeletal muscle ...

    • A Complex Human-Gut Microbiome Cultured in an Anaerobic Intestine-on-a-Chip 

      Jalili-Firoozinezhad, Sasan; Gazzaniga, Francesca; Calamari, Elizabeth; Camacho, Diogo; Fadel, Cicely; Bein, Amir; Swenor, Ben; Nestor, Bret; Cronce, Michael; Levy, Oren; Gregory, Katherine; Breault, David; Cabral, Joaquim; Novak, Richard; Kasper, Dennis; Tovaglieri, Alessio; Ingber, Donald (‎Nature Research, 2019-07)
      The diverse bacterial populations that comprise the commensal microbiome of the human intestine play a central role in health and disease. A method that sustains complex microbial communities in direct contact with living ...

    • Early Interactions of Murine Macrophages with Francisella tularensis Map to Mouse Chromosome 19 

      Fink, Avner; Hassan, Musa A.; Okan, Nihal A.; Sheffer, Michal; Camejo, Ana; Saeij, Jeroen P. J.; Kasper, Dennis L. (American Society of Microbiology, 2016)
      ABSTRACT Differences among individuals in susceptibility to infectious diseases can be modulated by host genetics. Much of the research in this field has aimed to identify loci within the host genome that are associated ...

    • Glycoconjugate vaccine using a genetically modified O antigen induces protective antibodies to Francisella tularensis 

      Stefanetti, Giuseppe; Okan, Nihal; Fink, Avner; Gardner, Erica; Kasper, Dennis (Proceedings of the National Academy of Sciences, 2019-03-14)
      Francisella tularensis is the causative agent of tularemia, a category A bioterrorism agent. The lipopolysaccharide (LPS) O antigen (OAg) of F. tularensis has been considered for use in a glycoconjugate vaccine, but conjugate ...

    • An intestinal commensal symbiosis factor controls neuroinflammation via TLR2-mediated CD39 signaling 

      Wang, Yan; Telesford, Kiel M.; Ochoa-Repáraz, Javier; Haque-Begum, Sakhina; Christy, Marc; Kasper, Eli J.; Wang, Li; Wu, Yan; Robson, Simon C.; Kasper, Dennis L.; Kasper, Lloyd H. (2014)
      The mammalian immune system constitutively senses vast quantities of commensal bacteria and their products through pattern recognition receptors, yet excessive immune reactivity is prevented under homeostasis. Intestinal ...

    • Kdo Hydrolase Is Required for Francisella tularensis Virulence and Evasion of TLR2-Mediated Innate Immunity 

      Okan, Nihal A.; Chalabaev, Sabina; Kim, Tae-Hyun; Fink, Avner; Ross, Robin A.; Kasper, Dennis L. (American Society of Microbiology, 2013)
      ABSTRACT The highly virulent Francisella tularensis subsp. tularensis has been classified as a category A bioterrorism agent. A live vaccine strain (LVS) has been developed but remains unlicensed in the United States because ...

    • Microbial Bile Acid Metabolites Modulate Gut RORγ+ Regulatory T Cell Homeostasis 

      Song, Xinyang; Sun, Ximei; Oh, Sungwhan F.; Wu, Meng; Zhang, Yanbo; Zheng, Wen; Geva Zatorsky, Naama; Jupp, Ray; Mathis, Diane; Benoist, Christophe; Kasper, Dennis (Springer Science and Business Media LLC, 2020-01-16)
      The metabolic pathways encoded by the human gut microbiome constantly interact with host gene products through numerous bioactive molecules1. Primary bile acids (BAs) are synthesized within hepatocytes and released into ...

    • Microbiota-Targeted Maternal Antibodies Protect Neonates From Enteric Infection 

      Zheng, Wen; Zhao, Wenjing; Wu, Meng; Song, Xinyang; Caro, Florence; Sun, Ximei; Gazzaniga, Francesca; Stefanetti, Giuseppe; Oh, Sungwhan; Mekalanos, John; Kasper, Dennis (Springer Science and Business Media LLC, 2020-01-23)
      Although maternal antibodies protect newborns from infection, little is known about how protective antibodies are induced without prior pathogen exposure. Here we show that neonatal mice lacking the capacity to produce IgG ...

    • A novel mechanism for glycoconjugate vaccine activation of the adaptive immune system 

      Avci, Fikri Yavuz; Li, Xiangming; Tsuji, Moriya; Kasper, Dennis Lee (2012)
      Although glycoconjugate vaccines have provided enormous health benefits globally, they have been less successful in significant high-risk populations. Exploring novel approaches to the enhancement of glycoconjugate ...

    • Role of Murine Intestinal Interleukin-1 Receptor 1-Expressing Lymphoid Tissue Inducer-Like Cells in Salmonella Infection 

      Chen, Vincent L.; Surana, Neeraj K.; Duan, Jinyou; Kasper, Dennis L. (Public Library of Science, 2013)
      Interleukin (IL)-1 signaling plays a critical role in intestinal immunology. Here, we report that the major population of intestinal lamina propria lymphocytes expressing IL-1 receptor 1 (IL-1R1) is the lymphoid tissue ...

    • Small Molecule Control of Virulence Gene Expression in Francisella tularensis 

      Charity, James Carl; Blalock, LeeAnn T.; Costante-Hamm, Michelle M.; Kasper, Dennis Lee; Dove, Simon L. (Public Library of Science, 2009)
      In Francisella tularensis, the SspA protein family members MglA and SspA form a complex that associates with RNA polymerase (RNAP) to positively control the expression of virulence genes critical for the intramacrophage ...