Now showing items 1-15 of 15

    • Adult Cardiac Progenitor Cell Aggregates Exhibit Survival Benefit Both In Vitro and In Vivo 

      Bauer, Michael; Kang, Lifeng; Qiu, Yiling; Wu, Jinhui; Peng, Michelle; Chen, Howard H.; Camci-Unal, Gulden; Bayomy, Ahmad F.; Sosnovik, David E.; Khademhosseini, Ali; Liao, Ronglih (Public Library of Science, 2012)
      Background: A major hurdle in the use of exogenous stems cells for therapeutic regeneration of injured myocardium remains the poor survival of implanted cells. To date, the delivery of stem cells into myocardium has largely ...
    • Antibody Derived Peptides for Detection of Ebola Virus Glycoprotein 

      Rodríguez-Martínez, Luis Mario; Marquez-Ipiña, Alan Roberto; López-Pacheco, Felipe; Pérez-Chavarría, Roberto; González-Vázquez, Juan Carlos; González-González, Everardo; Trujillo-de Santiago, Grissel; Ponce-Ponce de León, César Alejandro; Zhang, Yu Shrike; Dokmeci, Mehmet Remzi; Khademhosseini, Ali; Alvarez, Mario Moisés (Public Library of Science, 2015)
      Background: Current Ebola virus (EBOV) detection methods are costly and impractical for epidemic scenarios. Different immune-based assays have been reported for the detection and quantification of Ebola virus (EBOV) proteins. ...
    • Automated microfluidic platform of bead-based electrochemical immunosensor integrated with bioreactor for continual monitoring of cell secreted biomarkers 

      Riahi, Reza; Shaegh, Seyed Ali Mousavi; Ghaderi, Masoumeh; Zhang, Yu Shrike; Shin, Su Ryon; Aleman, Julio; Massa, Solange; Kim, Duckjin; Dokmeci, Mehmet Remzi; Khademhosseini, Ali (Nature Publishing Group, 2016)
      There is an increasing interest in developing microfluidic bioreactors and organs-on-a-chip platforms combined with sensing capabilities for continual monitoring of cell-secreted biomarkers. Conventional approaches such ...
    • Chip-Based Comparison of the Osteogenesis of Human Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells under Mechanical Stimulation 

      Park, Sang-Hyug; Sim, Woo Young; Min, Byoung-Hyun; Yang, Sang Sik; Khademhosseini, Ali; Kaplan, David L. (Public Library of Science, 2012)
      Adipose tissue-derived stem cells (ASCs) are considered as an attractive stem cell source for tissue engineering and regenerative medicine. We compared human bone marrow-derived mesenchymal stem cells (hMSCs) and hASCs ...
    • A combinatorial cell-laden gel microarray for inducing osteogenic differentiation of human mesenchymal stem cells 

      Dolatshahi-Pirouz, Alireza; Nikkhah, Mehdi; Gaharwar, Akhilesh K.; Hashmi, Basma; Guermani, Enrico; Aliabadi, Hamed; Camci-Unal, Gulden; Ferrante, Thomas; Foss, Morten; Ingber, Donald E.; Khademhosseini, Ali (Nature Publishing Group, 2014)
      Development of three dimensional (3D) microenvironments that direct stem cell differentiation into functional cell types remains a major challenge in the field of regenerative medicine. Here, we describe a new platform to ...
    • DNA directed self-assembly of shape-controlled hydrogels 

      Qi, Hao; Ghodousi, Majid; Du, Yanan; Grun, Casey; Bae, Hojae; Yin, Peng; Khademhosseini, Ali (2013)
      Using DNA as programmable, sequence specific ‘glues’, shape-controlled hydrogel units are self-assembled into prescribed structures. Here we report that aggregates are produced using hydrogel cubes with edge length ranging ...
    • Drug delivery systems in urology—getting “smarter” 

      Farokhzad, Omid Cameron; Dimitrakov, Jordan D.; Karp, Jeffrey MIchael; Khademhosseini, Ali; Freeman, Michael; Langer, Robert S. (Elsevier BV, 2006)
      Urology holds the most enviable position in the medical firmament. Unique among specialties in bringing the surgeon in contact with humans throughout the spectrum of human life—from newborn to geriatric patients—urologists ...
    • Google Glass-Directed Monitoring and Control of Microfluidic Biosensors and Actuators 

      Zhang, Yu Shrike; Busignani, Fabio; Ribas, João; Aleman, Julio; Rodrigues, Talles Nascimento; Shaegh, Seyed Ali Mousavi; Massa, Solange; Rossi, Camilla Baj; Taurino, Irene; Shin, Su-Ryon; Calzone, Giovanni; Amaratunga, Givan Mark; Chambers, Douglas Leon; Jabari, Saman; Niu, Yuxi; Manoharan, Vijayan; Dokmeci, Mehmet Remzi; Carrara, Sandro; Demarchi, Danilo; Khademhosseini, Ali (Nature Publishing Group, 2016)
      Google Glass is a recently designed wearable device capable of displaying information in a smartphone-like hands-free format by wireless communication. The Glass also provides convenient control over remote devices, primarily ...
    • Hybrid hydrogels containing vertically aligned carbon nanotubes with anisotropic electrical conductivity for muscle myofiber fabrication 

      Ahadian, Samad; Ramón-Azcón, Javier; Estili, Mehdi; Liang, Xiaobin; Ostrovidov, Serge; Shiku, Hitoshi; Ramalingam, Murugan; Nakajima, Ken; Sakka, Yoshio; Bae, Hojae; Matsue, Tomokazu; Khademhosseini, Ali (Nature Publishing Group, 2014)
      Biological scaffolds with tunable electrical and mechanical properties are of great interest in many different fields, such as regenerative medicine, biorobotics, and biosensing. In this study, dielectrophoresis (DEP) was ...
    • Hybrid Microscopy: Enabling Inexpensive High-Performance Imaging through Combined Physical and Optical Magnifications 

      Zhang, Yu Shrike; Chang, Jae-Byum; Alvarez, Mario Moisés; Trujillo-de Santiago, Grissel; Aleman, Julio; Batzaya, Byambaa; Krishnadoss, Vaishali; Ramanujam, Aishwarya Aravamudhan; Kazemzadeh-Narbat, Mehdi; Chen, Fei; Tillberg, Paul W.; Dokmeci, Mehmet Remzi; Boyden, Edward S.; Khademhosseini, Ali (Nature Publishing Group, 2016)
      To date, much effort has been expended on making high-performance microscopes through better instrumentation. Recently, it was discovered that physical magnification of specimens was possible, through a technique called ...
    • Injectable Graphene Oxide/Hydrogel-Based Angiogenic Gene Delivery System for Vasculogenesis and Cardiac Repair 

      Paul, Arghya; Hasan, Anwarul; Kindi, Hamood Al; Gaharwar, Akhilesh K.; Rao, Vijayaraghava T. S.; Nikkhah, Mehdi; Shin, Su Ryon; Krafft, Dorothee; Dokmeci, Mehmet R.; Shum-Tim, Dominique; Khademhosseini, Ali (American Chemical Society, 2014)
      The objective of this study was to develop an injectable and biocompatible hydrogel which can efficiently deliver a nanocomplex of graphene oxide (GO) and vascular endothelial growth factor-165 (VEGF) pro-angiogenic gene ...
    • Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions 

      Dolatshahi-Pirouz, Alireza; Nikkhah, Mehdi; Kolind, Kristian; Dokmeci, Mehmet R.; Khademhosseini, Ali (MDPI, 2011)
      As our population ages, there is a greater need for a suitable supply of engineered tissues to address a range of debilitating ailments. Stem cell based therapies are envisioned to meet this emerging need. Despite significant ...
    • Microfluidics-Assisted Fabrication of Gelatin-Silica Core–Shell Microgels for Injectable Tissue Constructs 

      Cha, Chaenyung; Oh, Jonghyun; Kim, Keekyoung; Qiu, Yiling; Joh, Maria; Shin, Su Ryon; Wang, Xin; Camci-Unal, Gulden; Wan, Kai-tak; Liao, Ronglih; Khademhosseini, Ali (American Chemical Society, 2013)
      Microfabrication technology provides a highly versatile platform for engineering hydrogels used in biomedical applications with high-resolution control and injectability. Herein, we present a strategy of microfluidics-assisted ...
    • Shear-Thinning Nanocomposite Hydrogels for the Treatment of Hemorrhage 

      Gaharwar, Akhilesh K.; Avery, Reginald K.; Assmann, Alexander; Paul, Arghya; McKinley, Gareth H.; Khademhosseini, Ali; Olsen, Bradley D. (American Chemical Society, 2014)
      Internal hemorrhaging is a leading cause of death after traumatic injury on the battlefield. Although several surgical approaches such as the use of fibrin glue and tissue adhesive have been commercialized to achieve ...
    • The use of charge-coupled polymeric microparticles and micromagnets for modulating the bioavailability of orally delivered macromolecules 

      Teply, Benjamin A.; Tong, Rong; Jeong, Seok Y.; Luther, Gaurav; Sherifi, Ines; Yim, Christopher H.; Khademhosseini, Ali; Farokhzad, Omid Cameron; Langer, Robert S.; Cheng, Jianjun (Elsevier BV, 2008)
      Protein drugs have low bioavailability after oral administration, which is due in part to fast transit of the drugs or drug delivery vehicles through the gastrointestinal tract. Increasing the time that the drugs spend in ...