Now showing items 1-6 of 6

    • DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction 

      Wang, Zhiwei; Inuzuka, Hiroyuki; Zhong, Jiateng; Fukushima, Hidefumi; Wan, Lixin; Liu, Pengda; Wei, Wenyi (Impact Journals LLC, 2012)
      The Mdm2 oncoprotein promotes p53 ubiquitination and destruction. Yet, exact molecular mechanisms of Mdm2 destruction itself, under DNA damaging conditions, remain unclear. Recently, we identified SCFβ-TRCP as a novel E3 ...
    • SCF\(^{β-TRCP}\) Suppresses Angiogenesis and Thyroid Cancer Cell Migration by Promoting Ubiquitination and Destruction of VEGF Receptor 2 

      Shaik, Shavali; Nucera, Carmelo; Inuzuka, Hiroyuki; Gao, Daming; Garnaas, Maija; Frechette, Gregory Martin; Harris, Lauren; Wan, Lixin; Fukushima, Hidefumi; Husain, Amjad; Nose, Vania; Fadda, Guido; Sadow, Peter Mark; Goessling, Wolfram; North, Trista Elizabeth; Lawler, Jack William; Wei, Wenyi (The Rockefeller University Press, 2012)
      The incidence of human papillary thyroid cancer (PTC) is increasing and an aggressive subtype of this disease is resistant to treatment with vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor. VEGFR2 promotes ...
    • SCFβ-TRCP promotes cell growth by targeting PR-Set7/Set8 for degradation 

      Wang, Zhiwei; Dai, Xiangpeng; Zhong, Jiateng; Inuzuka, Hiroyuki; Wan, Lixin; Li, Xiaoning; Wang, Lixia; Ye, Xiantao; Sun, Liankun; Gao, Daming; Zou, Lee; Wei, Wenyi (Nature Publishing Group, 2015)
      The Set8/PR-Set7/KMT5a methyltransferase plays critical roles in governing transcriptional regulation, cell cycle progression and tumorigenesis. Although CRL4Cdt2 was reported to regulate Set8 stability, deleting the PIP ...
    • SCFβ-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration 

      Zhong, Jiateng; Shaik, Shavali; Wan, Lixin; Tron, Adriana E.; Wang, Zhiwei; Sun, Liankun; Inuzuka, Hiroyuki; Wei, Wenyi (Impact Journals LLC, 2013)
      Metastasis suppressor 1 (MTSS1) is an important tumor suppressor protein, and loss of MTSS1 expression has been observed in several types of human cancers. Importantly, decreased MTSS1 expression is associated with more ...
    • SCFβ-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway 

      Liu, Jia; Wan, Lixin; Liu, Pengda; Inuzuka, Hiroyuki; Liu, Jiankang; Wang, Zhiwei; Wei, Wenyi (Impact Journals LLC, 2014)
      The HECT domain-containing ubiquitin E3 ligase NEDD4 is widely expressed in mammalian tissues and plays a crucial role in governing a wide spectrum of cellular processes including cell growth, tissue development and ...
    • Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signaling to suppress tumorigenesis 

      Liu, Pengda; Gan, Wenjian; Inuzuka, Hiroyuki; Lazorchak, Adam S; Gao, Daming; Arojo, Omotooke; Liu, Dou; Wan, Lixin; Zhai, Bo; Yu, Yonghao; Yuan, Min; Kim, Byeong Mo; Shaik, Shavali; Menon, Suchithra; Gygi, Steven P.; Lee, Tae Ho; Asara, John M; Manning, Brendan D.; Blenis, John; Su, Bing; Wei, Wenyi (2013)
      The mechanistic target of rapamycin (mTOR) functions as a critical regulator of cellular growth and metabolism by forming multi-component, yet functionally distinct complexes mTORC1 and mTORC2. Although mTORC2 has been ...