Now showing items 1-17 of 17

    • Acetylation of C/EBPα inhibits its granulopoietic function 

      Bararia, Deepak; Kwok, Hui Si; Welner, Robert S.; Numata, Akihiko; Sárosi, Menyhárt B.; Yang, Henry; Wee, Sheena; Tschuri, Sebastian; Ray, Debleena; Weigert, Oliver; Levantini, Elena; Ebralidze, Alexander K.; Gunaratne, Jayantha; Tenen, Daniel G. (Nature Publishing Group, 2016)
      CCAAT/enhancer-binding protein alpha (C/EBPα) is an essential transcription factor for myeloid lineage commitment. Here we demonstrate that acetylation of C/EBPα at lysine residues K298 and K302, mediated at least in part ...
    • BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells 

      Schemionek, M.; Elling, C.; Steidl, U.; Baumer, N.; Hamilton, A.; Spieker, T.; Gothert, J. R.; Stehling, M.; Wagers, Amy Jo; Huettner, Claudia Sonja; Tenen, Daniel Geoffrey; Tickenbrock, L.; Berdel, W. E.; Serve, H.; Holyoake, T. L.; Muller-Tidow, C.; Koschmieder, S. (American Society of Hematology, 2010)
      In a previously developed inducible transgenic mouse model of chronic myeloid leukemia, we now demonstrate that the disease is transplantable using BCR-ABL+ Lin−Sca-1+c-kit+ (LSK) cells. Interestingly, the phenotype is ...
    • BIM Mediates EGFR Tyrosine Kinase Inhibitor-Induced Apoptosis in Lung Cancers with Oncogenic EGFR Mutations 

      Costa, Daniel Botelho; Halmos, Balázs; Kumar, Amit; Schumer, Susan T; Huberman, Mark Stephen; Boggon, Titus J; Tenen, Daniel Geoffrey; Kobayashi, Susumu (Public Library of Science, 2007)
      Background: Epidermal growth factor receptor (EGFR) mutations are present in the majority of patients with non-small cell lung cancer (NSCLC) responsive to the EGFR tyrosine kinase inhibitors (TKIs) gefitinib or erlotinib. ...
    • C/EBPa controls acquisition and maintenance of adult hematopoietic stem cell quiescence 

      Ye, Min; Zhang, Hong; Amabile, Giovanni; Yang, Henry; Staber, Philipp B.; Zhang, Pu; Levantini, Elena; Alberich-Jordà, Meritxell; Zhang, Junyan; Kawasaki, Akira; Tenen, Daniel G. (2013)
      Summary In blood, transcription factor C/EBPa is essential for myeloid differentiation and has been implicated in regulating self-renewal of fetal liver (FL) hematopoietic stem cells (HSCs). However, its function in adult ...
    • Cyclic AMP Responsive Element Binding Proteins Are Involved in ‘Emergency’ Granulopoiesis through the Upregulation of CCAAT/Enhancer Binding Protein β 

      Hirai, Hideyo; Kamio, Naoka; Huang, Gang; Matsusue, Akiko; Ogino, Shinpei; Kimura, Nobuhiko; Satake, Sakiko; Ashihara, Eishi; Imanishi, Jiro; Tenen, Daniel Geoffrey; Maekawa, Taira (Public Library of Science, 2013)
      In contrast to the definitive role of the transcription factor, CCAAT/Enhancer binding protein α (C/EBPα), in steady-state granulopoiesis, previous findings have suggested that granulopoiesis during emergency situations, ...
    • Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding 

      Ptasinska, A; Assi, S A; Mannari, D; Williamson, D; Dunne, J; Hoogenkamp, M; Care, M; McNeill, H; Cauchy, P; Cullen, M; Tooze, R M; Cockerill, P N; Westhead, D R; Heidenreich, O; Bonifer, C; James, S. R.; Wu, M.; Tenen, Daniel Geoffrey; Young, B. D. (Nature Publishing Group, 2012)
      The t(8;21) translocation fuses the DNA-binding domain of the hematopoietic master regulator RUNX1 to the ETO protein. The resultant RUNX1/ETO fusion protein is a leukemia-initiating transcription factor that interferes ...
    • A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma 

      Chan, Tim Hon Man; Lin, Chi Ho; Qi, Lihua; Fei, Jing; Li, Yan; Yong, Kol Jia; Liu, Ming; Song, Yangyang; Chow, Raymond Kwok Kei; Ng, Vanessa Hui En; Yuan, Yun-Fei; Tenen, Daniel G; Guan, Xin-Yuan; Chen, Leilei (BMJ Publishing Group, 2014)
      Objective: Hepatocellular carcinoma (HCC) is a heterogeneous tumour displaying a complex variety of genetic and epigenetic changes. In human cancers, aberrant post-transcriptional modifications, such as alternative splicing ...
    • Dissecting the role of aberrant DNA methylation in human leukemia 

      Amabile, Giovanni; Di Ruscio, Annalisa; Müller, Fabian; Welner, Robert S; Yang, Henry; Ebralidze, Alexander K; Zhang, Hong; Levantini, Elena; Qi, Lihua; Martinelli, Giovanni; Brummelkamp, Thijn; Le Beau, Michelle M; Figueroa, Maria E; Bock, Christoph; Tenen, Daniel G (2015)
      Chronic Myeloid Leukemia (CML) is a myeloproliferative disorder characterized by the genetic translocation t(9;22)(q34;q11.2) encoding for the BCR-ABL fusion oncogene. However, many molecular mechanisms of the disease ...
    • DNMT1-interacting RNAs block gene specific DNA methylation 

      Di Ruscio, Annalisa; Ebralidze, Alexander K.; Benoukraf, Touati; Amabile, Giovanni; Goff, Loyal A.; Terragni, Joylon; Figueroa, Maria Eugenia; De Figureido Pontes, Lorena Lobo; Alberich-Jorda, Meritxell; Zhang, Pu; Wu, Mengchu; D’Alò, Francesco; Melnick, Ari; Leone, Giuseppe; Ebralidze, Konstantin K.; Pradhan, Sriharsa; Rinn, John L.; Tenen, Daniel G. (2013)
      Summary DNA methylation was described almost a century ago. However, the rules governing its establishment and maintenance remain elusive. Here, we present data demonstrating that active transcription regulates levels of ...
    • Down regulation of PSA by C/EBPα is associated with loss of AR expression and inhibition of PSA promoter activity in the LNCaP cell Line 

      Yin, Hong; Radomska, Hanna S.; Tenen, Daniel Geoffrey; Glass, Jonathan (BioMed Central, 2006)
      Background: C/EBPα is a transcription factor essential for terminal differentiation of several cell types. It has not known if C/EBPα protein is expressed and functions in the prostate gland. Methods: The presence of C/EBPα ...
    • Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells 

      Aikawa, Yukiko; Yamagata, Kazutsune; Katsumoto, Takuo; Shima, Yutaka; Shino, Mika; Stanley, E Richard; Cleary, Michael L; Akashi, Koichi; Tenen, Daniel G; Kitabayashi, Issay (BlackWell Publishing Ltd, 2014)
      Acute myeloid leukemia is a clonal malignant disorder derived from a small number of leukemic stem cells (LSCs). Rearrangements of the mixed lineage leukemia (MLL) gene are found in acute myeloid leukemia associated with ...
    • The hematopoietic master regulator RUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis 

      Lichtinger, Monika; Obier, Nadine; Ingram, Richard; Hannah, Rebecca; Hoogenkamp, Maarten; Vijayabaskar, MS; Wu, Mengchu; Assi, Salam A; Tenen, Daniel Geoffrey; Westhead, David R; Kouskoff, Valerie; Lacaud, Georges; Göttgens, Berthold; Bonifer, Constanze (BioMed Central, 2013)
    • Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia 

      Guibal, F. C.; Alberich-Jorda, M.; Hirai, H.; Ebralidze, Alexander K.; Levantini, Elena; Di Ruscio, A.; Zhang, Pu; Santana-Lemos, B. A.; Neuberg, Donna S.; Wagers, Amy Jo; Rego, E. M.; Tenen, Daniel Geoffrey (American Society of Hematology, 2009)
      Acute promyelocytic leukemia (APL) is characterized by a block in differentiation and accumulation of promyelocytes in the bone marrow and blood. The majority of APL patients harbor the t(15:17) translocation leading to ...
    • A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression 

      Giotopoulos, George; van der Weyden, Louise; Osaki, Hikari; Rust, Alistair G.; Gallipoli, Paolo; Meduri, Eshwar; Horton, Sarah J.; Chan, Wai-In; Foster, Donna; Prinjha, Rab K.; Pimanda, John E.; Tenen, Daniel G.; Vassiliou, George S.; Koschmieder, Steffen; Adams, David J.; Huntly, Brian J.P. (The Rockefeller University Press, 2015)
      The introduction of highly selective ABL-tyrosine kinase inhibitors (TKIs) has revolutionized therapy for chronic myeloid leukemia (CML). However, TKIs are only efficacious in the chronic phase of the disease and effective ...
    • RUNX1 Reshapes the Epigenetic Landscape at the Onset of Haematopoiesis 

      Lichtinger, Monika; Ingram, Richard; Hannah, Rebecca; Müller, Dorothee; Clarke, Deborah; Assi, Salam A; Lie-A-Ling, Michael; Noailles, Laura; Vijayabaskar, M S; Wu, Mengchu; Westhead, David R; Kouskoff, Valerie; Lacaud, Georges; Göttgens, Berthold; Bonifer, Constanze; Tenen, Daniel Geoffrey (Nature Publishing Group, 2012)
      Cell fate decisions during haematopoiesis are governed by lineage-specific transcription factors, such as RUNX1, SCL/TAL1, FLI1 and C/EBP family members. To gain insight into how these transcription factors regulate the ...
    • SALL4 is a new target in endometrial cancer 

      Li, Ailing; Jiao, Yisheng; Yong, Kol Jia; Wang, Fei; Gao, Chong; Yan, Benedict; Srivastava, Supriya; Lim, Gkeok Stzuan Diana; Tang, Ping; Yang, Henry; Tenen, Daniel G; Chai, Li (2014)
      Aggressive cancers and embryonic stem (ES) cells share a common gene expression signature. Identifying the key factors/pathway(s) within this ES signature responsible for the aggressiveness of cancers can lead to a potential ...
    • Targeting Transcription Factor SALL4 in Acute Myeloid Leukemia by Interrupting Its Interaction with an Epigenetic Complex 

      Gao, Chong; Dimitrov, Todor; Yong, Kol Jia; Tatetsu, Hiro; Jeong, Ha-Won; Luo, Hongbo; Bradner, James Elliott; Tenen, Daniel Geoffrey; Chai, Li (American Society of Hematology, 2013)
      An exciting recent approach to targeting transcription factors in cancer is to block formation of oncogenic complexes. We investigated whether interfering with the interaction of the transcription factor SALL4, which is ...