Now showing items 1-2 of 2

    • Aminoimidazole Carboxamide Ribonucleotide (AICAR) Inhibits the Growth of Retinoblastoma In Vivo by Decreasing Angiogenesis and Inducing Apoptosis 

      Theodoropoulou, Sofia; Brodowska, Katarzyna; Kayama, Maki; Morizane, Yuki; Miller, Joan Whitten; Gragoudas, Evangelos Stelios; Vavvas, Demetrios (Public Library of Science, 2013)
      5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR), an analog of AMP is widely used as an activator of AMP-kinase (AMPK), a protein that regulates the responses of the cell to energy change. Recently, we showed ...
    • Effects of metformin on retinoblastoma growth in vitro and in vivo 

      BRODOWSKA, KATARZYNA; THEODOROPOULOU, SOFIA; HÖRSTE, MELISSA MEYER ZU; PASCHALIS, ELEFTHERIOS I.; TAKEUCHI, KIMIO; SCOTT, GORDON; RAMSEY, DAVID J.; KIERNAN, ELIZABETH; HOANG, MIEN; CICHY, JOANNA; MILLER, JOAN W.; GRAGOUDAS, EVANGELOS S.; VAVVAS, DEMETRIOS G. (D.A. Spandidos, 2014)
      Recent studies suggest that the anti-diabetic drug metformin may reduce the risk of cancer and have anti-proliferative effects for some but not all cancers. In this study, we examined the effects of metformin on human ...