Now showing items 1-3 of 3

    • Altered expression of protein tyrosine phosphatase, non-receptor type 22 isoforms in systemic lupus erythematosus 

      Chang, Hui-Hsin; Tseng, William; Cui, Jing; Costenbader, Karen; Ho, I-Cheng (BioMed Central, 2014)
      Introduction: A C-to-T single nucleotide polymorphism (SNP) located at position 1858 of human protein tyrosine phosphatase, non-receptor type 22 (PTPN22) complementary DNA (cDNA) is associated with an increased risk of ...
    • PTPN22.6, a Dominant Negative Isoform of PTPN22 and Potential Biomarker of Rheumatoid Arthritis 

      Chang, Hui-Hsin; Tai, Tzong-Shyuan; Lu, Bing; Iannaccone, Christine; Cernadas, Manuela; Weinblatt, Michael Elliott; Shadick, Nancy Ann; Miaw, Shi-Chuen; Ho, I-Cheng (Public Library of Science, 2012)
      PTPN22 is a tyrosine phosphatase and functions as a damper of TCR signals. A C-to-T single nucleotide polymorphism (SNP) located at position 1858 of human PTPN22 cDNA and converting an arginine (R620) to tryptophan (W620) ...
    • Reciprocal Regulation of C-Maf Tyrosine Phosphorylation by Tec and Ptpn22 

      Liu, Chih-Chun; Yen, Wei-Feng; Lai, Chen-Yen; Lin, Yu-Hsien; Chang, Hui-Hsin; Tai, Tzong-Shyuan; Lu, Yu-Jung; Tsao, Hsiao-Wei; Ho, I-Cheng; Miaw, Shi-Chuen (Public Library of Science, 2015)
      C-Maf plays an important role in regulating cytokine production in TH cells. Its transactivation of IL-4 is optimized by phosphorylation at Tyr21, Tyr92, and Tyr131. However, the molecular mechanism regulating its tyrosine ...