Now showing items 1-20 of 46

    • Activated Human Eosinophils 

      Melo, Rossana C.N.; Weller, Peter Fahey; Dvorak, Ann M. (S. Karger AG, 2005)
      Eosinophils are leukocytes which, when stimulated with cytokines or chemokines, become activated and release mediators stored in their dominant population of cytoplasmic granules (termed specific or secondary granules) ...
    • Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7 

      Tedla, N.; Bandeira-Melo, C.; Tassinari, P.; Sloane, D. E.; Samplaski, M.; Cosman, D.; Borges, L.; Weller, Peter Fahey; Arm, J. P. (Proceedings of the National Academy of Sciences, 2003)
      Eosinophils are implicated prominently in allergic diseases and the host response to parasitic infections. Eosinophils may be activated in vitro by diverse classes of agonists such as immunoglobulins, lipid mediators, and ...
    • Advances in diagnosis and treatment of eosinophilia 

      Sheikh, Javed; Weller, Peter Fahey (Ovid Technologies (Wolters Kluwer Health), 2009)
      Purpose of review — Hypereosinophilic syndromes (HESs) are disorders characterized by sustained blood or tissue hypereosinophilia or both with subsequent damage to various organs due to eosinophilic infiltration and release ...
    • Airway Eosinophils: Allergic Inflammation Recruited Professional Antigen-Presenting Cells 

      Wang, H.-B.; Ghiran, I.; Matthaei, K.; Weller, Peter Fahey (The American Association of Immunologists, 2007)
      The capacity of airway eosinophils, potentially pertinent to allergic diseases of the upper and lower airways, to function as professional APCs, those specifically able to elicit responses from unprimed, Ag-naive CD4+ T ...
    • Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes 

      Valent, Peter; Klion, Amy D.; Horny, Hans-Peter; Roufosse, Florence; Gotlib, Jason; Weller, Peter Fahey; Hellmann, Andrzej; Metzgeroth, Georgia; Leiferman, Kristin M.; Arock, Michel; Butterfield, Joseph H.; Sperr, Wolfgang R.; Sotlar, Karl; Vandenberghe, Peter; Haferlach, Torsten; Simon, Hans-Uwe; Reiter, Andreas; Gleich, Gerald J. (Elsevier BV, 2012)
      Eosinophilia is an important indicator of various neoplastic and nonneoplastic conditions. Depending on the underlying disease and mechanisms, eosinophil infiltration can lead to organ dysfunction, clinical symptoms, or ...
    • Contributions of Electron Microscopy to Understand Secretion of Immune Mediators by Human Eosinophils 

      Melo, Rossana C.N.; Dvorak, Ann M.; Weller, Peter Fahey (Cambridge University Press (CUP), 2010)
      Mechanisms governing secretion of proteins underlie the biologic activities and functions of human eosinophils, leukocytes of the innate immune system, involved in allergic, inflammatory, and immunoregulatory responses. ...
    • Cysteinyl leukotrienes acting via granule membrane-expressed receptors elicit secretion from within cell-free human eosinophil granules 

      Neves, Josiane S.; Radke, Amy L.; Weller, Peter Fahey (Elsevier BV, 2010)
      Background—Cysteinyl leukotrienes are recognized to act via receptors (CysLTRs) expressed on cell surface plasma membranes. Agents that block CysLT1R, are therapeutics for allergic disorders. Eosinophils contain multiple ...
    • Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion 

      Spencer, L. A.; Melo, R. C. N.; Perez, S. A. C.; Bafford, S. P.; Dvorak, A. M.; Weller, Peter Fahey (Proceedings of the National Academy of Sciences, 2006)
      Although leukocytes of the innate immune system, including eosinophils, contain within their granules preformed stores of cytokines available for selective and rapid release, little is known about the mechanisms governing ...
    • EicosaCell – An Immunofluorescent-Based Assay to Localize Newly Synthesized Eicosanoid Lipid Mediators at Intracellular Sites 

      Bandeira-Melo, Christianne; Weller, Peter Fahey; Bozza, Patricia T. (Springer Science + Business Media, 2010)
      Eicosanoids (prostaglandins, leukotrienes and lipoxins) are a family of signaling lipids derived from arachidonic acid that have important roles in physiological and pathological processes. Over the past years, it has been ...
    • Electron tomography and immunonanogold electron microscopy for investigating intracellular trafficking and secretion in human eosinophils 

      Melo, Rossana C. N.; Dvorak, Ann M.; Weller, Peter Fahey (Wiley-Blackwell, 2008)
      Electron tomography (ET) has increasingly been used to understand the complexity of membrane systems and protein-trafficking events. By ET and immunonanogold electron microscopy, we recently defined a route for vesicular ...
    • Eosinophil granules function extracellularly as receptor-mediated secretory organelles 

      Neves, J. S.; Perez, S. A. C.; Spencer, L. A.; Melo, R. C. N.; Reynolds, L.; Ghiran, I.; Mahmudi-Azer, S.; Odemuyiwa, S. O.; Dvorak, A. M.; Moqbel, R.; Weller, Peter Fahey (Proceedings of the National Academy of Sciences, 2008)
      Intracellular granules in several types of leukocytes contain preformed proteins whose secretions contribute to immune and inflammatory functions of leukocytes, including eosinophils, cells notably associated with asthma, ...
    • Eosinophil purification from peripheral blood 

      Akuthota, Praveen; Capron, Kelsey; Weller, Peter Fahey (Springer Science + Business Media, 2014)
      Eosinophils are granulocytes integral to allergic inflammation and parasitic responses and comprise 1-4 % of the circulating leukocytes in human beings under normal conditions. Isolation of human eosinophils allows for ex ...
    • Eosinophil Secretion of Granule-Derived Cytokines 

      Spencer, Lisa A.; Bonjour, Kennedy; Melo, Rossana C. N.; Weller, Peter F. (Frontiers Media S.A., 2014)
      Eosinophils are tissue-dwelling leukocytes, present in the thymus, and gastrointestinal and genitourinary tracts of healthy individuals at baseline, and recruited, often in large numbers, to allergic inflammatory foci and ...
    • Eosinophilic pneumonias 

      Akuthota, P.; Weller, Peter Fahey (American Society for Microbiology, 2012)
      This review starts with discussions of several infectious causes of eosinophilic pneumonia, which are almost exclusively parasitic in nature. Pulmonary infections due specifically to Ascaris, hookworms, Strongyloides, ...
    • Eosinophils and disease pathogenesis 

      Akuthota, Praveen; Weller, Peter Fahey (Elsevier BV, 2012)
      Eosinophils are granulocytic innate immune cells whose presence is conspicuous in a variety of disease states, including eosinophilic hyperproliferative and infiltrative processes, as well as conditions associated with ...
    • Eosinophils and Th2 immunity: contemporary insights 

      Spencer, Lisa Ann; Weller, Peter Fahey (Nature Publishing Group, 2010)
      Eosinophils, innate immune leukocytes elicited by Th2 cells, have long been associated with the effector arm of Th2 immune responses. However, accumulating data over the past decade reveal a much more dynamic picture of ...
    • Eosinophils as antigen-presenting cells in allergic upper airway disease 

      Akuthota, Praveen; Wang, Haibin; Weller, Peter Fahey (Ovid Technologies (Wolters Kluwer Health), 2010)
      Purpose of Review—The recognition of eosinophils as complex immunomodulatory cells has been increasing in recent years. One prominent novel immunomodulatory function of eosinophils is their role as antigen presenting cells ...
    • Extracellular Microvesicle Production by Human Eosinophils Activated by “Inflammatory” Stimuli 

      Akuthota, Praveen; Carmo, Lívia A. S.; Bonjour, Kennedy; Murphy, Ryann O.; Silva, Thiago P.; Gamalier, Juliana P.; Capron, Kelsey L.; Tigges, John; Toxavidis, Vasilis; Camacho, Virginia; Ghiran, Ionita; Ueki, Shigeharu; Weller, Peter F.; Melo, Rossana C. N. (Frontiers Media S.A., 2016)
      A key function of human eosinophils is to secrete cytokines, chemokines and cationic proteins, trafficking, and releasing these mediators for roles in inflammation and other immune responses. Eosinophil activation leads ...
    • Functional extracellular eosinophil granules: Novel implications in eosinophil immunobiology 

      Neves, Josiane S; Weller, Peter Fahey (Elsevier BV, 2009)
      Human eosinophils contain within their cytoplasmic granules multiple preformed proteins, including over three dozen cytokines with nominal Th1, Th2 and immunoregulatory capabilities, and four distinctive cationic proteins. ...
    • A Gel-Based Dual Antibody Capture and Detection Method for Assaying of Extracellular Cytokine Secretion: EliCell 

      Spencer, Lisa Ann; Melo, Rossana; Perez, Sandra A. C.; Weller, Peter Fahey (2005)
      A distinguishing feature of eosinophils is their ability to rapidly release preformed cytokines from intracellular pools. Cytokines are delivered to the cell surface from granule stores by transport vesicles and are released ...