Now showing items 1-5 of 5

    • Anthrax Toxin Receptor 2 Determinants that Dictate the pH Threshold of Toxin Pore Formation 

      Scobie, Heather M.; Marlett, John M.; Rainey, G. Jonah A.; Lacy, D. Borden; Collier, R. John; Young, John A.T. (Public Library of Science, 2007)
      The anthrax toxin receptors, ANTXR1 and ANTXR2, act as molecular clamps to prevent the protective antigen (PA) toxin subunit from forming pores until exposure to low pH. PA forms pores at pH ∼6.0 or below when it is bound ...
    • Anthrax Toxin Receptor 2-Dependent Lethal Toxin Killing In Vivo 

      Scobie, Heather M; Wigelsworth, Darran J; Marlett, John M; Thomas, Diane; Rainey, G. Jonah A; Lacy, D. Borden; Manchester, Marianne; Collier, R. John; Young, John A. T (Public Library of Science, 2006)
      Anthrax toxin receptors 1 and 2 (ANTXR1 and ANTXR2) have a related integrin-like inserted (I) domain which interacts with a metal cation that is coordinated by residue D683 of the protective antigen (PA) subunit of anthrax ...
    • Anthrax Toxins Regulate Pain Signaling and Can Deliver Molecular Cargoes Into ANTXR2+ DRG Sensory Neurons 

      Yang, Nicole J.; Isensee, Jörg; Neel, Dylan V.; Quadros, Andreza U.; Zhang, Han-Xiong Bear; Lauzadis, Justas; Liu, Sai Man; Shiers, Stephanie; Belu, Andreea; Palan, Shilpa; Marlin, Sandra; Maignel, Jacquie; Kennedy-Curran, Angela; Tong, Victoria S.; Moayeri, Mahtab; Röderer, Pascal; Nitzsche, Anja; Lu, Mike; Pentelute, Bradley L.; Brüstle, Oliver; Tripathi, Vineeta; Foster, Keith A.; Price, Theodore J.; Collier, Robert; Leppla, Stephen H.; Puopolo, Michelino; Bean, Bruce; Cunha, Thiago M.; Hucho, Tim; Chiu, Isaac (Springer Science and Business Media LLC, 2021-12-20)
      Bacterial products can act on neurons to alter signaling and function. In the present study, we found that dorsal root ganglion (DRG) sensory neurons are enriched for ANTXR2, the high-affinity receptor for anthrax toxins. ...
    • Changing the Receptor Specificity of Anthrax Toxin 

      Mechaly, Adva; McCluskey, Andrew Jeffrey; Collier, R. J (American Society of Microbiology, 2012)
      The actions of many bacterial toxins depend on their ability to bind to one or more cell-surface receptors. Anthrax toxin acts by a sequence of events that begins when the protective-antigen (PA) moiety of the toxin binds ...
    • Evidence for a Proton–Protein Symport Mechanism in the Anthrax Toxin Channel 

      Basilio, Daniel; Juris, Stephen J.; Collier, R. John; Finkelstein, Alan (Rockefeller University Press, 2009)
      The toxin produced by Bacillus anthracis, the causative agent of anthrax, is composed of three proteins: a translocase heptameric channel, (PA\(_{63})_7\), formed from protective antigen (PA), which allows the other two ...