Now showing items 1-4 of 4

    • Kaposi’s Sarcoma Herpesvirus Genome Persistence 

      Juillard, Franceline; Tan, Min; Li, Shijun; Kaye, Kenneth M. (Frontiers Media S.A., 2016)
      Kaposi’s sarcoma-associated herpesvirus (KSHV) has an etiologic role in Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. These diseases are most common in immunocompromised individuals, ...
    • KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA 

      Ponnusamy, Rajesh; Petoukhov, Maxim V.; Correia, Bruno; Custodio, Tania F.; Juillard, Franceline; Tan, Min; Pires de Miranda, Marta; Carrondo, Maria A.; Simas, J. Pedro; Kaye, Kenneth M.; Svergun, Dmitri I.; McVey, Colin E. (Oxford University Press, 2015)
      Latency-associated nuclear antigen (LANA) is central to episomal tethering, replication and transcriptional regulation of γ2-herpesviruses. LANA binds cooperatively to the terminal repeat (TR) region of the viral episome ...
    • Stringent homology-based prediction of H. sapiens-M. tuberculosis H37Rv protein-protein interactions 

      Zhou, Hufeng; Gao, Shangzhi; Nguyen, Nam Ninh; Fan, Mengyuan; Jin, Jingjing; Liu, Bing; Zhao, Liang; Xiong, Geng; Tan, Min; Li, Shijun; Wong, Limsoon (BioMed Central, 2014)
      Background: H. sapiens-M. tuberculosis H37Rv protein-protein interaction (PPI) data are essential for understanding the infection mechanism of the formidable pathogen M. tuberculosis H37Rv. Computational prediction is an ...
    • Synthesis of 2′-Fluoro RNA by Syn5 RNA polymerase 

      Zhu, Bin; Hernandez, Alfredo; Tan, Min; Wollenhaupt, Jan; Tabor, Stanley; Richardson, Charles C. (Oxford University Press, 2015)
      The substitution of 2′-fluoro for 2′-hydroxyl moieties in RNA substantially improves the stability of RNA. RNA stability is a major issue in RNA research and applications involving RNA. We report that the RNA polymerase ...