Now showing items 1-2 of 2

    • A20 deficiency causes spontaneous neuroinflammation in mice 

      Guedes, Renata Padilha; Csizmadia, Eva; Moll, Herwig P; Ma, Averil; Ferran, Christiane; da Silva, Cleide Gonçalves (BioMed Central, 2014)
      Background: A20 (TNFAIP3) is a pleiotropic NFκB-dependent gene that terminates NFκB activation in response to inflammatory stimuli. The potent anti-inflammatory properties of A20 are well characterized in several organs. ...
    • The ubiquitin-modifying enzyme A20 restricts the ubiquitination of RIPK3 and protects cells from necroptosis 

      Onizawa, Michio; Oshima, Shigeru; Schulze-Topphoff, Ulf; Oses-Prieto, Juan A; Lu, Timothy; Tavares, Rita; Prodhomme, Thomas; Duong, Bao; Whang, Michael I.; Advincula, Rommel; Agelidis, Alex; Barrera, Julio; Wu, Hao; Burlingame, Alma; Malynn, Barbara A.; Zamvil, Scott S.; Ma, Averil (2015)
      A20 is an anti-inflammatory protein linked to multiple human diseases, however the mechanisms by which A20 prevents inflammatory disease are incompletely defined. We now find that A20 deficient T cells and fibroblasts are ...