Now showing items 1-9 of 9

    • Effects of airborne pollutants on mitochondrial DNA Methylation 

      Byun, Hyang-Min; Panni, Tommaso; Motta, Valeria; Hou, Lifang; Nordio, Francesco; Apostoli, Pietro; Bertazzi, Pier Alberto; Baccarelli, Andrea (BioMed Central, 2013)
      Background: Mitochondria have small mitochondrial DNA (mtDNA) molecules independent from the nuclear DNA, a separate epigenetic machinery that generates mtDNA methylation, and are primary sources of oxidative-stress ...
    • Evolutionary age of repetitive element subfamilies and sensitivity of DNA methylation to airborne pollutants 

      Byun, Hyang-Min; Motta, Valeria; Panni, Tommaso; Bertazzi, Pier Alberto; Apostoli, Pietro; Hou, Lifang; Baccarelli, Andrea A (BioMed Central, 2013)
      Background: Repetitive elements take up >40% of the human genome and can change distribution through transposition, thus generating subfamilies. Repetitive element DNA methylation has associated with several diseases and ...
    • Heart rate variability and DNA methylation levels are altered after short-term metal fume exposure among occupational welders: a repeated-measures panel study 

      Fan, Tianteng; Fang, Shona C; Cavallari, Jennifer M; Barnett, Ian J; Wang, Zhaoxi; Su, Li; Byun, Hyang-Min; Lin, Xihong; Baccarelli, Andrea A; Christiani, David C (BioMed Central, 2014)
      Background: In occupational settings, boilermakers are exposed to high levels of metallic fine particulate matter (PM2.5) generated during the welding process. The effect of welding PM2.5 on heart rate variability (HRV) ...
    • Increased Mitochondrial DNA Copy Number in Occupations Associated with Low-Dose Benzene Exposure 

      Carugno, Michele; Pesatori, Angela Cecilia; Dioni, Laura; Hoxha, Mirjam; Bollati, Valentina; Albetti, Benedetta; Bonzini, Matteo; Fustinoni, Silvia; Cocco, Pierluigi; Satta, Giannina; Zucca, Mariagrazia; Merlo, Domenico Franco; Cipolla, Massimo; Bertazzi, Pier Alberto; Byun, Hyang-Min; Baccarelli, Andrea (National Institute of Environmental Health Sciences, 2011)
      Background: Benzene is an established leukemogen at high exposure levels. Although low-level benzene exposure is widespread and may induce oxidative damage, no mechanistic biomarkers are available to detect biological ...
    • Mono-Allelic Retrotransposon Insertion Addresses Epigenetic Transcriptional Repression in Human Genome 

      Byun, Hyang-Min; Heo, Kyu; Mitchell, Kasey J; Yang, Allen S (BioMed Central, 2012)
      Background: Retrotransposons have been extensively studied in plants and animals and have been shown to have an impact on human genome dynamics and evolution. Their ability to move within genomes gives retrotransposons to ...
    • Nutrients Intake Is Associated with DNA Methylation of Candidate Inflammatory Genes in a Population of Obese Subjects 

      Bollati, Valentina; Favero, Chiara; Albetti, Benedetta; Tarantini, Letizia; Moroni, Alice; Byun, Hyang-Min; Motta, Valeria; Conti, Diana Misaela; Tirelli, Amedea Silvia; Vigna, Luisella; Bertazzi, Pier Alberto; Pesatori, Angela Cecilia (MDPI, 2014)
      The aim of the present study was to evaluate the potential association between dietary nutrients and alterations in DNA methylation in a set of five candidate genes, including CD14, Et-1, iNOS, HERV-w and TNFα, in a ...
    • Particulate Matter, DNA Methylation in Nitric Oxide Synthase, and Childhood Respiratory Disease 

      Breton, Carrie V.; Salam, Muhammad T.; Wang, Xinhui; Byun, Hyang-Min; Siegmund, Kimberly D.; Gilliland, Frank D. (National Institute of Environmental Health Sciences, 2012)
      Background: Air pollutants have been associated with childhood asthma and wheeze. Epigenetic regulation of nitric oxide synthase—the gene responsible for nitric oxide production—may be affected by air pollutants and ...
    • Predicting DNA methylation level across human tissues 

      Ma, Baoshan; Wilker, Elissa H.; Willis-Owen, Saffron A. G.; Byun, Hyang-Min; Wong, Kenny C. C.; Motta, Valeria; Baccarelli, Andrea A.; Schwartz, Joel; Cookson, William O. C. M.; Khabbaz, Kamal; Mittleman, Murray A.; Moffatt, Miriam F.; Liang, Liming (Oxford University Press, 2014)
      Differences in methylation across tissues are critical to cell differentiation and are key to understanding the role of epigenetics in complex diseases. In this investigation, we found that locus-specific methylation ...
    • Temporal Stability of Epigenetic Markers: Sequence Characteristics and Predictors of Short-Term DNA Methylation Variations 

      Byun, Hyang-Min; Nordio, Francesco; Coull, Brent Andrew; Tarantini, Letizia; Hou, Lifang; Bonzini, Matteo; Apostoli, Pietro; Bertazzi, Pier Alberto; Baccarelli, Andrea (Public Library of Science, 2012)
      Background: DNA methylation is an epigenetic mechanism that has been increasingly investigated in observational human studies, particularly on blood leukocyte DNA. Characterizing the degree and determinants of DNA methylation ...