Now showing items 1-10 of 10

    • Anti-Inflammatory Effect of Targeted Delivery of SOD to Endothelium: Mechanism, Synergism with NO Donors and Protective Effects In Vitro and In Vivo 

      Shuvaev, Vladimir V.; Han, Jingyan; Tliba, Samira; Arguiri, Evguenia; Christofidou-Solomidou, Melpo; Ramirez, Servio H.; Dykstra, Holly; Persidsky, Yuri; Atochin, Dmitriy N.; Huang, Paul L.; Muzykantov, Vladimir R. (Public Library of Science, 2013)
      Pro-inflammatory activation of vascular endothelium is implicated in pathogenesis of severe conditions including stroke, infarction and sepsis. We have recently reported that superoxide dismutase (SOD) conjugated with ...
    • C-Reactive Protein Causes Insulin Resistance in Mice Through Fcγ Receptor IIB–Mediated Inhibition of Skeletal Muscle Glucose Delivery 

      Tanigaki, Keiji; Vongpatanasin, Wanpen; Barrera, Jose A.; Atochin, Dmitriy N.; Huang, Paul L.; Bonvini, Ezio; Shaul, Philip W.; Mineo, Chieko (American Diabetes Association, 2013)
      Elevations in C-reactive protein (CRP) are associated with an increased risk of insulin resistance. Whether CRP plays a causal role is unknown. Here we show that CRP transgenic mice and wild-type mice administered recombinant ...
    • eNOS Protects from Atherosclerosis Despite Relevant Superoxide Production by the Enzyme in apoE\(^{−/−}\) Mice 

      Ponnuswamy, Padmapriya; Schröttle, Angelika; Ostermeier, Eva; Grüner, Sabine; Huang, Paul Lee; Ertl, Georg; Hoffmann, Ulrich; Nieswandt, Bernhard; Kuhlencordt, Peter J. (Public Library of Science, 2012)
      Background: All three nitric oxide synthase (NOS) isoforms are expressed in atherosclerotic plaques. NOS enzymes in general catalyse NO production. However, under conditions of substrate and cofactor deficiency, the enzyme ...
    • Loss of Insulin Signaling in Vascular Endothelial Cells Accelerates Atherosclerosis in Apolipoprotein E Null Mice 

      Rask-Madsen, Christian; Li, Qian; Freund, Bryn; Feather, Danielle; Abramov, Roman; Wu, I-Hsien; Chen, Kai; Yamamoto-Hiraoka, Junko; Goldenbogen, Jan; Sotiropoulos, Konstantinos B.; Clermont, Allen Charles; Geraldes, Pedro; Dall, Claudia; Wagers, Amy Jo; Huang, Paul Lee; Rekhter, Mark; Scalia, Rosario; Kahn, C. Ronald; King, George Liang (Elsevier BV, 2010)
      To determine whether insulin action on endothelial cells promotes or protects against atherosclerosis, we generated apolipoprotein E null mice in which the insulin receptor gene was intact or conditionally deleted in ...
    • Nitric Oxide and Postconditioning: Cardioprotective Methods for Acute Care of Ischemia Reperfusion Injury 

      Pong, Terrence Kwok Cay (2012-11-13)
      Timely coronary artery reperfusion is essential to prevent myocyte death following myocardial infarction. The act of restoring blood flow however, paradoxically reduces the beneficial effects of reperfusion. This phenomenon, ...
    • Nitric oxide synthase 3 deficiency limits adverse ventricular remodeling after pressure overload in insulin resistance 

      Kurtz, Baptiste; Thibault, Helene B.; Raher, Michael J.; Popovich, John R.; Cawley, Sharon; Atochin, Dmitriy N.; Hayton, Sarah; Shakartzi, Hannah R.; Huang, Paul Lee; Bloch, Kenneth Daniel; Buys, Emmanuel; Scherrer-Crosbie, Marielle (American Physiological Society, 2011)
      Insulin resistance (IR) and systemic hypertension are independently associated with heart failure. We reported previously that nitric oxide synthase 3 (NOS3) has a beneficial effect on left ventricular (LV) remodeling and ...
    • Phosphomimetic Modulation of eNOS Improves Myocardial Reperfusion and Mimics Cardiac Postconditioning in Mice 

      Pong, Terrence; Scherrer-Crosbie, Marielle; Atochin, Dmitriy N.; Bloch, Kenneth D.; Huang, Paul L. (Public Library of Science, 2014)
      Objective: Myocardial infarction resulting from ischemia-reperfusion injury can be reduced by cardiac postconditioning, in which blood flow is restored intermittently prior to full reperfusion. Although key molecular ...
    • Soluble Guanylate Cyclase  1 1 Limits Stroke Size and Attenuates Neurological Injury 

      Atochin, Dmitriy N.; Yuzawa, Izumi; Li, Qian; Rauwerdink, Kristen M.; Malhotra, Rajeev; Chang, Junlei; Brouckaert, Peter; Ayata, Cenk; Moskowitz, Michael Arthur; Bloch, Kenneth Daniel; Huang, Paul Lee; Buys, Emmanuel (Ovid Technologies (Wolters Kluwer Health), 2010)
      Background and Purpose— Nitric oxide mediates endothelium-dependent vasodilation, modulates cerebral blood flow, and determines stroke outcome. Nitric oxide signals in part by stimulating soluble guanylate cyclase (sGC) ...
    • The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH): Design of a pharmacogenetic Resource for Type 2 Diabetes 

      Walford, Geoffrey A.; Colomo, Natalia; Todd, Jennifer N.; Billings, Liana K.; Fernandez, Marlene; Chamarthi, Bindu; Warner, A. Sofia; Davis, Jaclyn; Littleton, Katherine R.; Hernandez, Alicia M.; Fanelli, Rebecca R.; Lanier, Amelia; Barbato, Corinne; Ackerman, Rachel J.; Khan, Sabina Q.; Bui, Rosa; Garber, Laurel; Stolerman, Elliot S.; Moore, Allan F.; Huang, Chunmei; Kaur, Varinderpal; Harden, Maegan; Taylor, Andrew; Chen, Ling; Manning, Alisa K.; Huang, Paul; Wexler, Deborah; McCarthy, Rita M.; Lo, Janet; Thomas, Melissa K.; Grant, Richard W.; Goldfine, Allison; Hudson, Margo S.; Florez, Jose C. (Public Library of Science, 2015)
      Objective: Genome-wide association studies have uncovered a large number of genetic variants associated with type 2 diabetes or related phenotypes. In many cases the causal gene or polymorphism has not been identified, and ...
    • Through-skull fluorescence imaging of the brain in a new near-infrared window 

      Hong, Guosong; Diao, Shuo; Chang, Junlei; Antaris, Alexander L.; Chen, Changxin; Zhang, Bo; Zhao, Su; Atochin, Dmitriy N.; Huang, Paul L.; Andreasson, Katrin I.; Kuo, Calvin J.; Dai, Hongjie (2014)
      To date, brain imaging has largely relied on X-ray computed tomography and magnetic resonance angiography with limited spatial resolution and long scanning times. Fluorescence-based brain imaging in the visible and traditional ...