Browsing by Author "Coyne, Michael"

Now showing items 1-6 of 6

    • Bacteroidales Secreted Antimicrobial Proteins Target Surface Molecules Necessary for Gut Colonization and Mediate Competition In Vivo 

      Roelofs, Kevin G.; Coyne, Michael J.; Gentyala, Rahul R.; Chatzidaki-Livanis, Maria; Comstock, Laurie E. (American Society for Microbiology, 2016)
      ABSTRACT We recently showed that human gut Bacteroidales species secrete antimicrobial proteins (BSAPs), and we characterized in vitro the first such BSAP produced by Bacteroides fragilis. In this study, we identified a ...

    • Evidence of Extensive DNA Transfer between Bacteroidales Species within the Human Gut 

      Coyne, Michael J.; Zitomersky, Naamah Levy; McGuire, Abigail Manson; Earl, Ashlee M.; Comstock, Laurie E. (American Society of Microbiology, 2014)
      ABSTRACT The genome sequences of intestinal Bacteroidales strains reveal evidence of extensive horizontal gene transfer. In vitro studies of Bacteroides and other bacteria have addressed mechanisms of conjugative transfer ...

    • Genome-wide Chromatin State Transitions Associated with Developmental and Environmental Cues 

      Zhu, Jiang; Adli, Mazhar; Zou, James Y.; Verstappen, Griet; Coyne, Michael J.; Zhang, Xiaolan; Durham, Timothy; Miri, Mohammad; Deshpande, Vikram; De Jager, Philip L.; Bennett, David A.; Houmard, Joseph A.; Muoio, Deborah M.; Onder, Tamer T.; Camahort, Raymond; Cowan, Chad A.; Meissner, Alexander; Epstein, Charles B.; Shoresh, Noam; Bernstein, Bradley E. (Elsevier BV, 2013)
      Differences in chromatin organization are key to the multiplicity of cell states that arise from a single genetic background, yet the landscapes of in vivo tissues remain largely uncharted. Here, we mapped chromatin ...

    • Genome-wide Map of Quantified Epigenetic Changes during In vitro Chondrogenic Differentiation of Primary Human Mesenchymal Stem Cells 

      Herlofsen, Sarah; Bryne, Jan Christian; Høiby, Torill; Wang, Li; Issner, Robbyn; Zhang, Xiaolan; Coyne, Michael J.; Boyle, Patrick; Gu, Hongcang; Meza-Zepeda, Leonardo A; Collas, Philippe; Mikkelsen, Tarjei Sigurd; Brinchmann, Jan E (BioMed Central, 2013)
      Background: For safe clinical application of engineered cartilage made from mesenchymal stem cells (MSCs), molecular mechanisms for chondrogenic differentiation must be known in detail. Changes in gene expression and ...

    • Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells 

      Gifford, Casey A.; Ziller, Michael Johannes; Gu, Hongcang; Trapnell, Cole; Donaghey, Julie A; Tsankov, Alexander; Shalek, Alex K.; Kelley, David Roy; Shishkin, Alexander A.; Issner, Robbyn; Zhang, Xiaolan; Coyne, Michael J.; Fostel, Jennifer L.; Holmes, Laurie; Meldrim, Jim; Guttman, Mitchell; Epstein, Charles; Park, Hongkun; Kohlbacher, Oliver; Rinn, John L; Gnirke, Andreas; Lander, Eric Steven; Bernstein, Bradley E.; Meissner, Alexander (Elsevier BV, 2013)
      Differentiation of human embryonic stem cells (hESCs) provides a unique opportunity to study the regulatory mechanisms that facilitate cellular transitions in a human context. To that end, we performed comprehensive ...

    • Type VI secretion systems of human gut Bacteroidales segregate into three genetic architectures, two of which are contained on mobile genetic elements 

      Coyne, Michael J.; Roelofs, Kevin G.; Comstock, Laurie E. (BioMed Central, 2016)
      Background: Type VI secretion systems (T6SSs) are contact-dependent antagonistic systems employed by Gram negative bacteria to intoxicate other bacteria or eukaryotic cells. T6SSs were recently discovered in a few Bacteroidetes ...