Now showing items 1-3 of 3

    • Blockade of the Programmed Death-1 (PD1) Pathway Undermines Potent Genetic Protection from Type 1 Diabetes 

      Kochupurakkal, Nora M.; Kruger, Annie J.; Tripathi, Sudipta; Zhu, Bing; Adams, La Tonya; Rainbow, Daniel B.; Rossini, Aldo; Greiner, Dale L.; Sayegh, Mohamed H.; Wicker, Linda S.; Guleria, Indira (Public Library of Science, 2014)
      Aims/Hypothesis Inhibition of PD1-PDL1 signaling in NOD mice accelerates onset of type 1 diabetes implicating this pathway in suppressing the emergence of pancreatic beta cell reactive T-cells. However, the molecular ...
    • Key Features of the Intragraft Microenvironment that Determine Long-Term Survival Following Transplantation 

      Bruneau, Sarah; Woda, Craig B.; Daly, Kevin Patrick; Boneschansker, Leonard; Jain, Namrata G.; Kochupurakkal, Nora; Contreras, Alan Gabriel; Seto, Tatsuichiro; Briscoe, David Michael (Frontiers Research Foundation, 2012)
      In this review, we discuss how changes in the intragraft microenvironment serve to promote or sustain the development of chronic allograft rejection. We propose two key elements within the microenvironment that contribute ...
    • Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo 

      Nakayama, Hironao; Bruneau, Sarah; Kochupurakkal, Nora; Coma, Silvia; Briscoe, David M.; Klagsbrun, Michael (Nature Publishing Group, 2015)
      Semaphorin 3F (SEMA3F) provides neuronal guidance cues via its ability to bind neuropilin 2 (NRP2) and Plexin A family molecules. Recent studies indicate that SEMA3F has biological effects in other cell types, however its ...