Browsing by Author "Wu, Shulin"
Now showing items 1-7 of 7
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Combination of vinblastine and oncolytic herpes simplex virus vector expressing IL-12 therapy increases antitumor and antiangiogenic effects in prostate cancer models
Passer, Brent J.; Cheema, Tooba; Wu, Shulin; Wu, Chen-lee; Rabkin, Samuel D.; Martuza, Robert L. (2013)Oncolytic herpes simplex virus-1 (oHSV)–based vectors selectively replicate in tumor cells causing direct killing, ie., oncolysis, while sparing normal cells. oHSV’sare promising anticancer agents, but their efficacy, when ... -
Estrogen Receptor β2 and β5 are Associated with Poor Prognosis in Prostate Cancer, and Promote Cancer Cell Migration and Invasion
Leung, Yuet-Kin; Lam, Hung-Ming; Song, Dan; Levin, Linda; Ho, Shuk-Mei; Wu, Shulin; Cheng, Liang; Wu, Chin-Lee (Society for Endocrinology, 2010)Estrogens play a pivotal role in the development and progression of prostate cancer (PCa). Their actions are mediated by estrogen receptors (ERs), particularly ERβ in the prostate epithelium. With the discovery of ERβ ... -
Metformin represses cancer cells via alternate pathways in N-cadherin expressing vs. N-cadherin deficient cells
Ge, Rongbin; Wang, Zongwei; Wu, Shulin; Zhuo, Yangjia; Otsetov, Aleksandar G.; Cai, Chao; Zhong, Weide; Wu, Chin-Lee; Olumi, Aria F. (Impact Journals LLC, 2015)Metformin has emerged as a potential anticancer agent. Here, we demonstrate that metformin plays an anti-tumor role via repressing N-cadherin, independent of AMPK, in wild-type N-cadherin cancer cells. Ectopic-expression ... -
Mitotic Figure Recognition: Agreement among Pathologists and Computerized Detector
Malon, Christopher; Brachtel, Elena; Cosatto, Eric; Graf, Hans Peter; Kurata, Atsushi; Kuroda, Masahiko; Meyer, John S.; Saito, Akira; Wu, Shulin; Yagi, Yukako (IOS Press, 2012)Despite the prognostic importance of mitotic count as one of the components of the Bloom – Richardson grade [3], several studies ([2, 9, 10]) have found that pathologists’ agreement on the mitotic grade is fairly modest. ... -
Peutz-Jeghers syndrome: a critical look at colonic Peutz-Jeghers polyps
Tse, Julie Yi; Wu, Shulin; Shinagare, Shweta A; Lauwers, Gregory Y.; Yilmaz, Omer Hidir; Wu, Chin-Lee; Deshpande, Vikram (Springer Nature, 2013)Peutz-Jeghers syndrome is an autosomal dominant condition characterized by gastrointestinal hamartomatous polyps. The pathologic identification of a Peutz-Jeghers polyp is integral to the diagnosis of this syndrome that ... -
Preoperative Neutrophil-to-Lymphocyte Ratio and Neutrophilia Are Independent Predictors of Recurrence in Patients with Localized Papillary Renal Cell Carcinoma
Huang, Jiwei; Dahl, Douglas M.; Dong, Liang; Liu, Qiang; Cornejo, Kristine; Wang, Qi; Wu, Shulin; Feldman, Adam S.; Huang, Yiran; Xue, Wei; Wu, Chin-Lee (Hindawi Publishing Corporation, 2015)Objective:. To evaluate the role of preoperative neutrophil-to-lymphocyte ratio (NLR) and absolute neutrophil count (ANC) in patients' prognosis with localized papillary renal cell carcinoma (pRCC). Methods:. Data from 218 ... -
SOXs in Human Prostate Cancer: Implication as Progression and Prognosis Factors
Zhong, Wei-de; Qin, Guo-qiang; Dai, Qi-shan; Han, Zhao-dong; Chen, Shan-ming; Ling, Xiao-hui; Fu, Xin; Chen, Jia-hong; Chen, Xi-bin; Lin, Zhuo-yuan; Deng, Ye-han; He, Hui-chan; Wu, Chin-Lee; Wu, Shulin; Cai, Chao (BioMed Central, 2012)Background: SOX genes play an important role in a number of developmental processes. Potential roles of SOXs have been demonstrated in various neoplastic tissues as tumor suppressors or promoters depending on tumor status ...