Now showing items 1-6 of 6

    • Cell Type of Origin Influences the Molecular and Functional Properties of Mouse Induced Pluripotent Stem Cells 

      Polo, Jose M.; Liu, Susanna; Figueroa, Maria Eugenia; Kulalert, Warakorn; Eminli, Sarah; Tan, Kah Yong; Apostolou, Effie; Stadtfeld, Matthias; Li, Yushan; Shioda, Toshihiro; Natesan, Sridaran; Wagers, Amy Jo; Melnick, Ari; Evans, Todd; Hochedlinger, Konrad (Nature Publishing Group, 2010)
      Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPSCs generated from different cell types are molecularly ...
    • Dose-Related Estrogen Effects on Gene Expression in Fetal Mouse Prostate Mesenchymal Cells 

      Taylor, Julia A.; Richter, Catherine A.; Suzuki, Atsuko; Watanabe, Hajime; Iguchi, Taisen; Coser, Kathryn R.; Shioda, Toshihiro; vom Saal, Frederick S. (Public Library of Science, 2012)
      Developmental exposure of mouse fetuses to estrogens results in dose-dependent permanent effects on prostate morphology and function. Fetal prostatic mesenchyme cells express estrogen receptor alpha (ERα) and androgen ...
    • Fulvestrant-Induced Cell Death and Proteasomal Degradation of Estrogen Receptor α Protein in MCF-7 Cells Require the CSK c-Src Tyrosine Kinase 

      Yeh, Wei-Lan; Shioda, Keiko; Coser, Kathryn R.; Rivizzigno, Danielle; McSweeney, Kristen R.; Shioda, Toshihiro (Public Library of Science, 2013)
      Fulvestrant is a representative pure antiestrogen and a Selective Estrogen Receptor Down-regulator (SERD). In contrast to the Selective Estrogen Receptor Modulators (SERMs) such as 4-hydroxytamoxifen that bind to estrogen ...
    • Genome-wide Analysis of YY2 Versus YY1 Target Genes 

      Chen, Li; Shioda, Toshihiro; Coser, Kathryn R.; Lynch, Mary C.; Yang, Chuanwei; Schmidt, Emmett Vance (Oxford University Press, 2010)
      Yin Yang 1 (YY1) is a critical transcription factor controlling cell proliferation, development and DNA damage responses. Retrotranspositions have independently generated additional YY family members in multiple species. ...
    • Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells 

      Choi, Jiho; Huebner, Aaron; Clement, Kendell; Walsh, Ryan M.; Savol, Andrej J; Lin, Kaixuan; Gu, Hongcang; Di Stefano, Bruno; Brumbaugh, Justin; Kim, Sang-Yong; Sharif, Jafar; Rose, Christopher M.; Mohammad, Arman; Odajima, Junko; Charron, Jean; Shioda, Toshihiro; Gnirke, Andreas; Gygi, Steven P.; Koseki, Haruhiko; Sadreyev, Ruslan; Xiao, Andrew; Meissner, Alexander; Hochedlinger, Konrad (Springer Nature, 2017)
      Concomitant activation of the Wnt pathway and suppression of Mapk signalling by two small molecule inhibitors (2i) in the presence of leukaemia inhibitory factor (LIF) (hereafter termed 2i/L) induces a naive state in mouse ...
    • SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes 

      Tajima, Ken; Yae, Toshifumi; Javaid, Sarah; Tam, Oliver; Comaills, Valentine; Morris, Robert; Wittner, Ben S.; Liu, Mingzhu; Engstrom, Amanda; Takahashi, Fumiyuki; Black, Joshua C.; Ramaswamy, Sridhar; Shioda, Toshihiro; Hammell, Molly; Haber, Daniel A.; Whetstine, Johnathan R.; Maheswaran, Shyamala (Nature Pub. Group, 2015)
      Expression of the p53-inducible antiproliferative gene BTG2 is suppressed in many cancers in the absence of inactivating gene mutations, suggesting alternative mechanisms of silencing. Using a shRNA screen targeting 43 ...