Browsing by Author "Chu, Gerald C."

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    • Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development 

      Wiedemeyer, Ruprecht; Brennan, Cameron; Heffernan, Timothy P.; Xiao, Yonghong; Mahoney, John T.; Protopopov, Alexei; Zheng, Hongwu; Bignell, Graham; Furnari, Frank; Cavenee, Webster K.; Hahn, William C.; Ichimura, Koichi; Collins, Peter V.; Chu, Gerald C.; Stratton, Michael R.; Ligon, Keith Lloyd; Futreal, Andrew P.; Chin, Lynda (Cell Press, 2008)
      We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18^{INK4C} and p16^{INK4A} codeletion. Functional ...