Now showing items 1-3 of 3

    • Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth 

      Nemeth, Zsuzsanna; Csizmadia, Eva; Vikstrom, Lisa; Li, Mailin; Bisht, Kavita; Feizi, Alborz; Otterbein, Sherrie; Zuckerbraun, Brian; Costa, Daniel B.; Pandolfi, Pier Paolo; Fillinger, Janos; Döme, Balazs; Otterbein, Leo E.; Wegiel, Barbara (Impact Journals LLC, 2016)
      We hypothesized that tumor-associated macrophages (TAMs) are controlled by the diffusible gas carbon monoxide (CO). We demonstrate that induction of apoptosis in lung tumors treated with low doses of CO is associated with ...
    • Cystatin C is Downregulated in Prostate Cancer and Modulates Invasion of Prostate Cancer Cells via MAPK/Erk and Androgen Receptor Pathways 

      Wegiel, Barbara; Jiborn, Thomas; Abrahamson, Magnus; Helczynski, Leszek; Otterbein, Leo E.; Persson, Jenny Liao; Bjartell, Anders (Public Library of Science, 2009)
      Cystatin C is believed to prevent tumor progression by inhibiting the activities of a family of lysosomal cysteine proteases. However, little is known about the precise mechanism of cystatin C function in prostate cancer. ...
    • Heme oxygenase-1 in macrophages controls prostate cancer progression 

      Nemeth, Zsuzsanna; Li, Mailin; Csizmadia, Eva; Döme, Balazs; Johansson, Martin; Persson, Jenny Liao; Seth, Pankaj; Otterbein, Leo; Wegiel, Barbara (Impact Journals LLC, 2015)
      Innate immune cells strongly influence cancer growth and progression via multiple mechanisms including regulation of epithelial to mesenchymal transition (EMT). In this study, we investigated whether expression of the ...