Now showing items 1-6 of 6

    • FGF23 Deficiency Leads to Mixed Hearing Loss and Middle Ear Malformation in Mice 

      Lysaght, Andrew C.; Yuan, Quan; Fan, Yi; Kalwani, Neil; Caruso, Paul; Cunnane, MaryBeth; Lanske, Beate; Stanković, Konstantina M. (Public Library of Science, 2014)
      Fibroblast growth factor 23 (FGF23) is a circulating hormone important in phosphate homeostasis. Abnormal serum levels of FGF23 result in systemic pathologies in humans and mice, including renal phosphate wasting diseases ...
    • Immediate and Delayed Cochlear Neuropathy after Noise Exposure in Pubescent Mice 

      Jensen, Jane Bjerg; Lysaght, Andrew C.; Liberman, M. Charles; Qvortrup, Klaus; Stankovic, Konstantina M. (Public Library of Science, 2015)
      Moderate acoustic overexposure in adult rodents is known to cause acute loss of synapses on sensory inner hair cells (IHCs) and delayed degeneration of the auditory nerve, despite the completely reversible temporary threshold ...
    • Micro-optical coherence tomography of the mammalian cochlea 

      Iyer, Janani S.; Batts, Shelley A.; Chu, Kengyeh K.; Sahin, Mehmet I.; Leung, Hui Min; Tearney, Guillermo J.; Stankovic, Konstantina M. (Nature Publishing Group, 2016)
      The mammalian cochlea has historically resisted attempts at high-resolution, non-invasive imaging due to its small size, complex three-dimensional structure, and embedded location within the temporal bone. As a result, ...
    • Secreted Factors from Human Vestibular Schwannomas Can Cause Cochlear Damage 

      Dilwali, Sonam; Landegger, Lukas D.; Soares, Vitor Y. R.; Deschler, Daniel G.; Stankovic, Konstantina M. (Nature Publishing Group, 2015)
      Vestibular schwannomas (VSs) are the most common tumours of the cerebellopontine angle. Ninety-five percent of people with VS present with sensorineural hearing loss (SNHL); the mechanism of this SNHL is currently unknown. ...
    • Sulforaphane, a natural component of broccoli, inhibits vestibular schwannoma growth in vitro and in vivo 

      Kim, Bo Gyung; Fujita, Takeshi; Stankovic, Konstantina M.; Welling, D. Bradley; Moon, In Seok; Choi, Jae Young; Yun, Jieun; Kang, Jong Soon; Lee, Jong Dae (Nature Publishing Group, 2016)
      Vestibular schwannoma (VS) is an intracranial tumor that causes significant morbidity, including hearing loss, tinnitus, dizziness, and possibly even death from brainstem compression. However, FDA-approved pharmacologic ...
    • Transactivation of human osteoprotegerin promoter by GATA-3 

      Kao, Shyan-Yuan; Stankovic, Konstantina M. (Nature Publishing Group, 2015)
      Osteoprotegerin (OPG) is a key regulator of bone remodeling. Mutations in OPG are involved in a variety of human diseases. We have shown that cochlear spiral ganglion cells secrete OPG at high levels and lack of OPG causes ...