Browsing by Author "Jensen, Frances Elizabeth"
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Bumetanide Enhances Phenobarbital Efficacy in a Rat Model of Hypoxic Neonatal Seizures
Cleary, Ryan T.; Sun, Hongyun; Huynh, Thanhthao; Manning, Simon; Li, Yijun; Rotenberg, Alexander; Talos, Delia M.; Kahle, Kristopher Thomas; Jackson, Michele; Rakhade, Sanjay N.; Berry, Gerard T.; Jensen, Frances Elizabeth (Public Library of Science, 2013)Neonatal seizures can be refractory to conventional anticonvulsants, and this may in part be due to a developmental increase in expression of the neuronal Na+-K+-2 Cl− cotransporter, NKCC1, and consequent paradoxical ... -
The Interaction between Early Life Epilepsy and Autistic-Like Behavioral Consequences: A Role for the Mammalian Target of Rapamycin (mTOR) Pathway
Talos, Delia Maria; Sun, Hongyu; Zhou, Xiangping; Fitzgerald, Erin C.; Jackson, Michele C.; Klein, Peter M.; Lan, Victor J.; Joseph, Annelise; Jensen, Frances Elizabeth (Public Library of Science, 2012)Early life seizures can result in chronic epilepsy, cognitive deficits and behavioral changes such as autism, and conversely epilepsy is common in autistic children. We hypothesized that during early brain development, ... -
Regional Differences in Susceptibility to Hypoxic-Ischemic Injury in the Preterm Brain: Exploring the Spectrum from White Matter Loss to Selective Grey Matter Injury in a Rat Model
Selip, D. B.; Jantzie, Lauren; Chang, Mun Seog; Jackson, M. C.; Fitzgerald, E. C.; Boll, G.; Murphy, A.; Jensen, Frances Elizabeth (Hindawi Publishing Corporation, 2012)Models of premature brain injury have largely focused on the white matter injury thought to underlie periventricular leukomalacia (PVL). However, with increased survival of very low birth weight infants, injury patterns ...