Browsing by Author "Argueso, Pablo"

Now showing items 1-7 of 7

    • Alteration of Galectin-3 in Tears of Patients With Dry Eye Disease 

      Uchino, Yuichi; Mauris, Jerome; Woodward, Ashley Morgan; Dieckow, Julia; Amparo, Francisco; Dana, Reza; Mantelli, Flavio; Argueso, Pablo (Elsevier BV, 2015)
      Purpose To investigate the expression, release, and proteolytic degradation of galectin-3 in patients with dry eye disease. Design Observational case series with a comparison group. Methods Tear washes and ...

    • Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye 

      Bauskar, Aditi; Mack, Wendy J.; Mauris, Jerome; Argüeso, Pablo; Heur, Martin; Nagel, Barbara A.; Kolar, Grant R.; Gleave, Martin E.; Nakamura, Takahiro; Kinoshita, Shigeru; Moradian-Oldak, Janet; Panjwani, Noorjahan; Pflugfelder, Stephen C.; Wilson, Mark R.; Fini, M. Elizabeth; Jeong, Shinwu (Public Library of Science, 2015)
      Dry eye is a common disorder caused by inadequate hydration of the ocular surface that results in disruption of barrier function. The homeostatic protein clusterin (CLU) is prominent at fluid-tissue interfaces throughout ...

    • Decreased Levels of the Goblet Cell Mucin MUC5AC in Tears of Patients with Sjögren Syndrome 

      Argueso, Pablo; Balaram, Mini; Spurr-Michaud, Sandra; Keutmann, Henry Todd; Dana, Reza; Gipson, Ilene Kay (Association for Research in Vision and Ophthalmology, 2002)
      purpose. To determine whether the relative amounts of mucin mRNA in the conjunctival epithelium and mucin protein in the tears are altered in patients with Sjögren syndrome compared with healthy individuals. methods. ...

    • Endomucin prevents leukocyte–endothelial cell adhesion and has a critical role under resting and inflammatory conditions 

      Zahr, Alisar; Alcaide, Pilar; Yang, Jinling; Jones, Alexander; Gregory, Meredith; dela Paz, Nathaniel G.; Patel-Hett, Sunita; Nevers, Tania; Koirala, Adarsha; Luscinskas, Francis W.; Saint-Geniez, Magali; Ksander, Bruce; D'Amore, Patricia A.; Argüeso, Pablo (Nature Publishing Group, 2016)
      Endomucin is a membrane-bound glycoprotein expressed luminally by endothelial cells that line postcapillary venules, a primary site of leukocyte recruitment during inflammation. Here we show that endomucin abrogation on ...

    • Establishment of a novel in vitro model of stratified epithelial wound healing with barrier function 

      Gonzalez-Andrades, Miguel; Alonso-Pastor, Luis; Mauris, Jérôme; Cruzat, Andrea; Dohlman, Claes H.; Argüeso, Pablo (Nature Publishing Group, 2016)
      The repair of wounds through collective movement of epithelial cells is a fundamental process in multicellular organisms. In stratified epithelia such as the cornea and skin, healing occurs in three steps that include a ...

    • Impact of Cigarette Smoking on Tear Function and Correlation between Conjunctival Goblet Cells and Tear MUC5AC Concentration in Office Workers 

      Uchino, Yuichi; Uchino, Miki; Yokoi, Norihiko; Dogru, Murat; Kawashima, Motoko; Komuro, Aoi; Sonomura, Yukiko; Kato, Hiroaki; Argüeso, Pablo; Kinoshita, Shigeru; Tsubota, Kazuo (Nature Publishing Group, 2016)
      The first aim of this study was to clarify whether cigarette smoking affects tear secretion, goblet cell density, and tear MUC5AC concentration. The second purpose was to evaluate the correlations of conjunctival goblet ...

    • Modulation of Ocular Surface Glycocalyx Barrier Function by a Galectin-3 N-terminal Deletion Mutant and Membrane-Anchored Synthetic Glycopolymers 

      Mauris, Jerome; Mantelli, Flavio; Woodward, Ashley M.; Cao, Ziyhi; Bertozzi, Carolyn R.; Panjwani, Noorjahan; Godula, Kamil; Argüeso, Pablo (Public Library of Science, 2013)
      Background: Interaction of transmembrane mucins with the multivalent carbohydrate-binding protein galectin-3 is critical to maintaining the integrity of the ocular surface epithelial glycocalyx. This study aimed to determine ...