Browsing by Author "Henrich, Timothy J."

Now showing items 1-7 of 7

    • Evolution of coreceptor utilization to escape CCR5 antagonist therapy 

      Zhang, Jie; Gao, Xiang; Martin, John; Rosa, Bruce; Chen, Zheng; Mitreva, Makedonka; Henrich, Timothy; Kuritzkes, Daniel; Ratner, Lee (2016)
      The HIV-1 envelope interacts with coreceptors CCR5 and CXCR4 in a dynamic, multi-step process, its molecular details not clearly delineated. Use of CCR5 antagonists results in tropism shift and therapeutic failure. Here ...

    • Genome-Wide Association Study of Human Immunodeficiency Virus (HIV)-1 Coreceptor Usage in Treatment-Naive Patients from An AIDS Clinical Trials Group Study 

      Henrich, Timothy J.; McLaren, Paul J.; Rao, Suhas S. P.; Lin, Nina H.; Hanhauser, Emily; Giguel, Francoise; Gulick, Roy M.; Ribaudo, Heather; de Bakker, Paul I. W.; Kuritzkes, Daniel R. (Oxford University Press, 2014)
      Objectives. We conducted a genome-wide association study to explore whether common host genetic variants (>5% frequency) were associated with presence of virus able to use CXCR4 for entry. Methods. Phenotypic determination ...

    • HIV-1 persistence in CD4+ T cells with stem cell-like properties 

      Buzon, Maria J.; Sun, Hong; Li, Chun; Shaw, Amy; Seiss, Katherine; Ouyang, Zhengyu; Martin-Gayo, Enrique; Leng, Jin; Henrich, Timothy J.; Li, Jonathan Z.; Pereyra, Florencia; Zurakowski, Ryan; Walker, Bruce D.; Rosenberg, Eric S.; Yu, Xu G.; Lichterfeld, Mathias (2014)
      Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4+ T memory stem cells (TSCM) harbor high per-cell levels of HIV-1 ...

    • HIV-2 Encephalitis: Case Report and Literature Review 

      Wood, Brian R.; Klein, Joshua Peter; Lyons, Jennifer L; Milner, Danny Arnold; Phillips, Richard; Schutten, Martin; Folkerth, Rebecca Dunn; Ciarlini, Pedro; Henrich, Timothy Jensen; Johnson, Jennifer Ann (Mary Ann Liebert, 2012)
      We report the case of a 59-year-old man who moved from Cape Verde to Massachusetts at the age of 29. He had multiple sexual contacts with female partners in Cape Verde and with West African women in Massachusetts, as well ...

    • Increased Risk of Virologic Rebound in Patients on Antiviral Therapy with a Detectable HIV Load <48 Copies/mL 

      Henrich, Timothy Jensen; Wood, Brian R.; Kuritzkes, Daniel Robert (Public Library of Science, 2012)
      We investigated the independent effects of HIV-1 ”target not detected” measurements versus those that were detectable but below the limit of quantification by Taqman RT-PCR assay on subsequent viral rebound as there are ...

    • Nanostructured Optical Photonic Crystal Biosensor for HIV Viral Load Measurement 

      Shafiee, Hadi; Lidstone, Erich A.; Jahangir, Muntasir; Inci, Fatih; Hanhauser, Emily; Henrich, Timothy J.; Kuritzkes, Daniel R.; Cunningham, Brian T.; Demirci, Utkan (Nature Publishing Group, 2014)
      Detecting and quantifying biomarkers and viruses in biological samples have broad applications in early disease diagnosis and treatment monitoring. We have demonstrated a label-free optical sensing mechanism using ...

    • Printed Flexible Plastic Microchip for Viral Load Measurement through Quantitative Detection of Viruses in Plasma and Saliva 

      Shafiee, Hadi; Kanakasabapathy, Manoj Kumar; Juillard, Franceline; Keser, Mert; Sadasivam, Magesh; Yuksekkaya, Mehmet; Hanhauser, Emily; Henrich, Timothy J.; Kuritzkes, Daniel R.; Kaye, Kenneth M.; Demirci, Utkan (Nature Publishing Group, 2014)
      We report a biosensing platform for viral load measurement through electrical sensing of viruses on a flexible plastic microchip with printed electrodes. Point-of-care (POC) viral load measurement is of paramount importance ...