Now showing items 1-12 of 12

    • CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts 

      Greenblatt, Matthew B.; Park, Kwang Hwan; Oh, Hwanhee; Kim, Jung-Min; Shin, Dong Yeon; Lee, Jae Myun; Lee, Jin Woo; Singh, Anju; Lee, Ki-young; Hu, Dorothy; Xiao, Changchun; Charles, Julia F.; Penninger, Josef M.; Lotinun, Sutada; Baron, Roland; Ghosh, Sankar; Shim, Jae-Hyuck (The Rockefeller University Press, 2015)
      Physiological bone remodeling requires that bone formation by osteoblasts be tightly coupled to bone resorption by osteoclasts. However, relatively little is understood about how this coupling is regulated. Here, we ...
    • Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages 

      Kiviranta, Riku; Yamana, Kei; Saito, Hiroaki; Ho, Daniel K.; Laine, Julius; Tarkkonen, Kati; Nieminen-Pihala, Vappu; Hesse, Eric; Correa, Diego; Määttä, Jorma; Tessarollo, Lino; Rosen, Evan D.; Horne, William C.; Jenkins, Nancy A.; Copeland, Neal G.; Warming, Soren; Baron, Roland (The Rockefeller University Press, 2013)
      Bone homeostasis is maintained by the coupled actions of hematopoietic bone-resorbing osteoclasts (OCs) and mesenchymal bone-forming osteoblasts (OBs). Here we identify early B cell factor 1 (Ebf1) and the transcriptional ...
    • The Crosstalk between Osteoclasts and Osteoblasts Is Dependent upon the Composition and Structure of Biphasic Calcium Phosphates 

      Shiwaku, Yukari; Neff, Lynn; Nagano, Kenichi; Takeyama, Ken-Ichi; de Bruijn, Joost; Dard, Michel; Gori, Francesca; Baron, Roland (Public Library of Science, 2015)
      Biphasic calcium phosphates (BCPs), consisting of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), exhibit good biocompatibility and osteoconductivity, maintaining a balance between resorption of the biomaterial and ...
    • Deficiency of Retinaldehyde Dehydrogenase 1 Induces BMP2 and Increases Bone Mass In Vivo 

      Nallamshetty, Shriram; Wang, Hong; Rhee, Eun-Jung; Kiefer, Florian W.; Brown, Jonathan D.; Lotinun, Sutada; Le, Phuong; Baron, Roland; Rosen, Clifford J.; Plutzky, Jorge (Public Library of Science, 2013)
      The effects of retinoids, the structural derivatives of vitamin A (retinol), on post-natal peak bone density acquisition and skeletal remodeling are complex and compartment specific. Emerging data indicates that retinoids, ...
    • Dynamin and endocytosis are required for the fusion of osteoclasts and myoblasts 

      Shin, Nah-Young; Choi, Hyewon; Neff, Lynn; Wu, Yumei; Saito, Hiroaki; Ferguson, Shawn M.; De Camilli, Pietro; Baron, Roland (The Rockefeller University Press, 2014)
      Cell–cell fusion is an evolutionarily conserved process that leads to the formation of multinucleated myofibers, syncytiotrophoblasts and osteoclasts, allowing their respective functions. Although cell–cell fusion requires ...
    • Essential Function of Dynamin in the Invasive Properties and Actin Architecture of v-Src Induced Podosomes/Invadosomes 

      Destaing, Olivier; Ferguson, Shawn M.; Grichine, Alexei; Oddou, Christiane; De Camilli, Pietro; Albiges-Rizo, Corinne; Baron, Roland (Public Library of Science, 2013)
      The large GTPase dynamin plays a key role in endocytosis but is also localized at numerous actin rich sites. We investigated dynamin functions at podosomes/invadosomes, actin-based cellular adhesion structures implicated ...
    • Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning 

      Saez, Borja; Ferraro, F.; Yusuf, Rushdia Zareen; Cook, Colleen M.; Yu, Vionnie Wing Chi; Pardo-Saganta, A.; Sykes, Stephen M.; Palchaudhuri, Rahul; Schajnovitz, Amir; Lotinun, S; Lymperi, Stefania; Mendez-Ferrer, Simon; del Toro, Raquel; Day, Robyn Rouviere; Vasic, Radovan; Acharya, Sanket Shyamkant; Baron, Roland; Lin, Charles P.; Yamaguchi, Yu; Wagers, Amy Jo; Scadden, David Thomas (American Society of Hematology, 2014)
      The glycosyltransferase gene, Ext1, is essential for heparan sulfate production. Induced deletion of Ext1 selectively in Mx1-expressing bone marrow (BM) stromal cells, a known population of skeletal stem/progenitor cells, ...
    • The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2 

      Zou, Weiguo; Greenblatt, Matthew B.; Brady, Nicholas; Lotinun, Sutada; Zhai, Bo; de Rivera, Heather; Singh, Anju; Sun, Jun; Gygi, Steven P.; Baron, Roland; Glimcher, Laurie H.; Jones, Dallas C. (The Rockefeller University Press, 2013)
      Osteoblasts are responsible for the formation and mineralization of the skeleton. To identify novel regulators of osteoblast differentiation, we conducted an unbiased forward genetic screen using a lentiviral-based shRNA ...
    • Regulation of Early Adipose Commitment by Zfp521 

      Kang, Sona; Akerblad, Peter; Kiviranta, Riku; Gupta, Rana K.; Kajimura, Shingo; Griffin, Michael John; Min, Jie; Baron, Roland; Rosen, Evan David (Public Library of Science, 2012)
      While there has been significant progress in determining the transcriptional cascade involved in terminal adipocyte differentiation, less is known about early events leading to lineage commitment and cell fate choice. It ...
    • SIKs control osteocyte responses to parathyroid hormone 

      Wein, Marc N.; Liang, Yanke; Goransson, Olga; Sundberg, Thomas B.; Wang, Jinhua; Williams, Elizabeth A.; O'Meara, Maureen J.; Govea, Nicolas; Beqo, Belinda; Nishimori, Shigeki; Nagano, Kenichi; Brooks, Daniel J.; Martins, Janaina S.; Corbin, Braden; Anselmo, Anthony; Sadreyev, Ruslan; Wu, Joy Y.; Sakamoto, Kei; Foretz, Marc; Xavier, Ramnik J.; Baron, Roland; Bouxsein, Mary L.; Gardella, Thomas J.; Divieti-Pajevic, Paola; Gray, Nathanael S.; Kronenberg, Henry M. (Nature Publishing Group, 2016)
      Parathyroid hormone (PTH) activates receptors on osteocytes to orchestrate bone formation and resorption. Here we show that PTH inhibition of SOST (sclerostin), a WNT antagonist, requires HDAC4 and HDAC5, whereas PTH ...
    • SIRT1 Regulates Differentiation of Mesenchymal Stem Cells by Deacetylating β-Catenin 

      Simic, Petra; Zainabadi, Kayvan; Bell, Eric; Sykes, David Brian; Saez, Borja; Lotinun, Sutada; Baron, Roland; Scadden, David Thomas; Schipani, Ernestina; Guarente, Leonard (WILEY-VCH Verlag, 2013)
      Mesenchymal stem cells (MSCs) are multi-potent cells that can differentiate into osteoblasts, adipocytes, chondrocytes and myocytes. This potential declines with aging. We investigated whether the sirtuin SIRT1 had a ...
    • Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow 

      Yu, Vionnie W.C.; Saez, Borja; Cook, Colleen; Lotinun, Sutada; Pardo-Saganta, Ana; Wang, Ying-Hua; Lymperi, Stefania; Ferraro, Francesca; Raaijmakers, Marc H.G.P.; Wu, Joy Y.; Zhou, Lan; Rajagopal, Jayaraj; Kronenberg, Henry M.; Baron, Roland; Scadden, David T. (The Rockefeller University Press, 2015)
      Production of the cells that ultimately populate the thymus to generate α/β T cells has been controversial, and their molecular drivers remain undefined. Here, we report that specific deletion of bone-producing osteocalcin ...