Now showing items 1-18 of 18

    • Aire controls gene expression in the thymic epithelium with ordered stochasticity 

      Meredith, Matthew; Zemmour, David; Mathis, Diane; Benoist, Christophe (2015)
      Aire controls immunologic tolerance by inducing the ectopic thymic expression of many tissue-specific genes, acting broadly by removing stops on the transcriptional machinery. To better understand Aire’s specificity, we ...
    • Circulating C3 is Necessary and Sufficient for Induction of Autoantibody-Mediated Arthritis in a Mouse Model 

      Monach, Paul A; Verschoor, Admar; Jacobs, Jonathan P; Carroll, Michael C.; Wagers, Amy Jo; Benoist, Christophe O.; Mathis, Diane J. (John Wiley & Sons, 2007)
      Objective. For the inflammation characteristic of rheumatoid arthritis, the relative contribution of mediators produced locally in the synovium versus those circulating systemically is unknown. Complement factor C3 is made ...
    • Commercially Available Outbred Mice for Genome-Wide Association Studies 

      Yalcin, Binnaz; Nicod, Jérôme; Bhomra, Amarjit; Davidson, Stuart; Cleak, James; Farinelli, Laurent; Østerås, Magne; Whitley, Adam; Yuan, Wei; Gan, Xiangchao; Goodson, Martin; Klenerman, Paul; Satpathy, Ansu; Mott, Richard; Flint, Jonathan; Mathis, Diane J.; Benoist, Christophe O.; Adams, David J. (Public Library of Science, 2010)
      Genome-wide association studies using commercially available outbred mice can detect genes involved in phenotypes of biomedical interest. Useful populations need high-frequency alleles to ensure high power to detect ...
    • Dynamics of Tissue-Resident Regulatory T Cell Populations 

      Kolodin, Dmitriy Pavlovich (2014-06-06)
      In recent years, there has been a worldwide increase in obesity, which parallels a rise in pathologies, including type 2 diabetes, collectively termed the metabolic syndrome. Chronic, low-grade inflammation has been ...
    • Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging 

      Fu, Wenxian; Wojtkiewicz, Gregory; Weissleder, Ralph; Benoist, Christophe O.; Mathis, Diane J. (2012)
      All juvenile NOD mice exhibit insulitis, but there is substantial variation in their progression to diabetes. We demonstrate that a patient-validated magnetic-resonance-imaging (MRI) strategy to non-invasively visualize ...
    • Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells 

      Fu, Wenxian; Farache, Julia; Clardy, Susan M; Hattori, Kimie; Mander, Palwinder; Lee, Kevin; Rioja, Inmaculada; Weissleder, Ralph; Prinjha, Rab K; Benoist, Christophe; Mathis, Diane (eLife Sciences Publications, Ltd, 2014)
      Epigenetic modifiers are an emerging class of anti-tumor drugs, potent in multiple cancer contexts. Their effect on spontaneously developing autoimmune diseases has been little explored. We report that a short treatment ...
    • A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus 

      Huang, Guo-Jen; Smith, Adrian L.; Gray, Daniel H.D.; Cosgrove, Cormac; Singer, Benjamin H.; Edwards, Andrew; Sim, Stuart; Parent, Jack M.; Johnsen, Alyssa; Mott, Richard; Klenerman, Paul; Flint, Jonathan; Mathis, Diane J.; Benoist, Christophe O. (Public Library of Science, 2010)
      Neurogenesis continues through the adult life of mice in the subgranular zone of the dentate gyrus in the hippocampus, but its function remains unclear. Measuring cellular proliferation in the hippocampus of 719 outbred ...
    • A gut feeling about arthritis 

      Mathis, Diane (eLife Sciences Publications, Ltd, 2013)
      The gut microbiota of patients recently diagnosed with rheumatoid arthritis is enriched in microbes belonging to the Prevotella genus.
    • A multiple redundant genetic switch locks in the transcriptional signature of T regulatory cells 

      Fu, Wenxian; Ergun, Ayla; Lu, Ting; Hill, Jonathan A.; Haxhinasto, Sokol; Fassett, Marlys S.; Gazit, Roi; Adoro, Stanley; Glimcher, Laurie; Chan, Susan; Kastner, Philippe; Rossi, Derrick; Collins, James J.; Mathis, Diane; Benoist, Christophe (2013)
      The transcription factor FoxP3 partakes dominantly in the specification and function of FoxP3+CD4+ T regulatory cells (Tregs), but is neither strictly necessary nor sufficient to determine the characteristic Treg signature. ...
    • Neonatal Tolerance Revisited: A Perinatal Window for Aire Control of Autoimmunity 

      Guerau-de-Arellano, Mireia; Martinic, Marianne; Benoist, Christophe O.; Mathis, Diane J. (The Rockefeller University Press, 2009)
      There has long been conceptual and experimental support for, but also challenges to, the notion that the initial period of the immune system's development is particularly important for the establishment of tolerance to ...
    • The neuropeptide neuromedin U promotes autoantibody-mediated arthritis 

      Rao, Sindhuja M; Auger, Jennifer L; Gaillard, Philippe; Weissleder, Ralph; Wada, Etsuko; Torres, Richard; Kojima, Masayasu; Benoist, Christophe O.; Mathis, Diane J.; Binstadt, Bryce A (BioMed Central, 2012)
      Introduction: Neuromedin U (NMU) is a neuropeptide with pro-inflammatory activity. The primary goal of this study was to determine if NMU promotes autoantibody-induced arthritis. Additional studies addressed the cellular ...
    • PPARγ is a Major Driver of the Accumulation and Phenotype of Adipose-Tissue \(T_{reg}\) Cells 

      Cipolletta, Daniela; Feuerer, Markus; Li, Amy; Kamei, Nozomu; Lee, Jongsoon; Shoelson, Steven E.; Benoist, Christophe O.; Mathis, Diane J. (Nature Publishing Group, 2012)
      Obesity and type-2 diabetes have increased markedly over the past few decades, in parallel. One of the major links between these two disorders is chronic, low-grade inflammation. Prolonged nutrient excess promotes the ...
    • Rapid, high efficiency isolation of pancreatic ß-cells 

      Clardy, Susan M.; Mohan, James F.; Vinegoni, Claudio; Keliher, Edmund J.; Iwamoto, Yoshiko; Benoist, Christophe; Mathis, Diane; Weissleder, Ralph (Nature Publishing Group, 2015)
      The ability to isolate pure pancreatic ß-cells would greatly aid multiple areas of diabetes research. We developed a fluorescent exendin-4-like neopeptide conjugate for the rapid purification and isolation of functional ...
    • Regulation and Heterogeneity of Pancreatic Natural Killer Cells During Type 1 Diabetes 

      Sitrin, Jonathan Ryan (2014-10-21)
      The vertebrate immune system contains a diverse inventory of genetic, epigenetic, molecular and cellular mechanisms dedicated to distinguishing and to determining appropriate responsiveness to "self" and "non-self." ...
    • Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2 

      Sitrin, Jonathan; Ring, Aaron; Garcia, K. Christopher; Benoist, Christophe; Mathis, Diane (The Rockefeller University Press, 2013)
      Regulatory T (T reg) cells control progression to autoimmune diabetes in the BDC2.5/NOD mouse model by reining in natural killer (NK) cells that infiltrate the pancreatic islets, inhibiting both their proliferation and ...
    • A Revival of the B Cell Paradigm for Rheumatoid Arthritis Pathogenesis? 

      Benoist, Christophe O.; Mathis, Diane J. (BioMed Central, 2000)
      Dominant paradigms for the understanding of rheumatoid arthritis (RA) pathogenesis have changed over the years. A predominant role of B lymphocytes, and perhaps of the rheumatoid factor they produced, was initially invoked. ...
    • Thymic negative selection is functional in NOD mice 

      Mingueneau, Michael; Jiang, Wenyu; Feuerer, Markus; Mathis, Diane J.; Benoist, Christophe O. (The Rockefeller University Press, 2012)
      Based on analyses of multiple TCR transgenic (tg) models, the emergence of pathogenic T cells in diabetes-prone NOD mice has been ascribed to a failure to censure autoreactive clones in the thymus. In contrast, using ...
    • The transcriptional landscape of αβ T cell differentiation 

      Mingueneau, Michael; Kreslavsky, Taras; Gray, Daniel; Heng, Tracy; Cruse, Richard; Ericson, Jeffrey; Bendall, Sean; Spitzer, Matt; Nolan, Garry; Kobayashi, Koichi; von Boehmer, Harald; Mathis, Diane; Benoist, Christophe (2013)
      αβT cell differentiation from thymic precursors is a complex process, explored here with the breadth of ImmGen expression datasets, analyzing how differentiation of thymic precursors gives rise to transcriptomes. After ...