Now showing items 1-18 of 18

    • Abnormal white matter microstructure and increased extracellular free-water in the cingulum bundle associated with delusions in chronic schizophrenia 

      Oestreich, Lena K.L.; Pasternak, Ofer; Shenton, Martha E.; Kubicki, Marek; Gong, Xue; McCarthy-Jones, Simon; Whitford, Thomas J. (Elsevier, 2016)
      Background: There is growing evidence to suggest that delusions associated with schizophrenia arise from altered structural brain connectivity. The present study investigated whether structural changes in three major ...
    • Applying a free-water correction to diffusion imaging data uncovers stress-related neural pathology in depression 

      Bergamino, Maurizio; Pasternak, Ofer; Farmer, Madison; Shenton, Martha E.; Paul Hamilton, J. (Elsevier, 2015)
      Diffusion tensor imaging (DTI) holds promise for developing our understanding of white-matter pathology in major depressive disorder (MDD). Variable findings in DTI-based investigations of MDD, however, have thwarted ...
    • Comparing free water imaging and magnetization transfer measurements in schizophrenia 

      Mandl, René C.W.; Pasternak, Ofer; Cahn, Wiepke; Kubicki, Marek R.; Kahn, René S.; Shenton, Martha Elizabeth; Hulshoff Pol, Hilleke E. (Elsevier BV, 2015)
      Diffusion weighted imaging (DWI) has been extensively used to study the microarchitecture of white matter in schizophrenia. However, popular DWI-derived measures such as fractional anisotropy (FA) may be sensitive to many ...
    • Diffusion MRI of Structural Brain Plasticity Induced by a Learning and Memory Task 

      Blumenfeld-Katzir, Tamar; Pasternak, Ofer; Dagan, Michael; Assaf, Yaniv (Public Library of Science, 2011)
      Background: Activity-induced structural remodeling of dendritic spines and glial cells was recently proposed as an important factor in neuroplasticity and suggested to accompany the induction of long-term potentiation ...
    • Early Brain Loss in Circuits Affected by Alzheimer’s Disease is Predicted by Fornix Microstructure but may be Independent of Gray Matter 

      Fletcher, Evan; Carmichael, Owen; Pasternak, Ofer; Maier-Hein, Klaus H.; DeCarli, Charles (Frontiers Media S.A., 2014)
      In a cohort of community-recruited elderly subjects with normal cognition at initial evaluation, we found that baseline fornix white matter (WM) microstructure was significantly correlated with early volumetric longitudinal ...
    • Estimation of Extracellular Volume from Regularized Multi-shell Diffusion MRI 

      Pasternak, Ofer; Shenton, Martha Elizabeth; Westin, Carl-Fredrik (Springer Science + Business Media, 2012)
      Diffusion MRI measures micron scale displacement of water molecules, providing unique insight into microstructural tissue architecture. However, current practical image resolution is in the millimeter scale, and thus ...
    • Excessive Extracellular Volume Reveals a Neurodegenerative Pattern in Schizophrenia Onset 

      Pasternak, Ofer; Westin, Carl-Fredrik; Bouix, Sylvain; Seidman, Larry Joel; Goldstein, Jill M.; Woo, Tsung-Ung Wilson; Petryshen, Tracey Lynn; Mesholam-Gately, Raquelle; McCarley, Robert William; Kikinis, Ron; Shenton, Martha Elizabeth; Kubicki, Marek R. (Society for Neuroscience, 2012)
      Diffusion MRI has been successful in identifying the existence of white matter abnormalities in schizophrenia in vivo. However, the role of these abnormalities in the etiology of schizophrenia is not well understood. ...
    • Gray matter alterations in early aging: A diffusion magnetic resonance imaging study 

      Rathi, Yogesh; Pasternak, Ofer; Savadjiev, Peter; Michailovich, O.; Bouix, Sylvain; Kubicki, Marek R.; Westin, Carl-Fredrik; Makris, Nikolaos; Shenton, Martha Elizabeth (Wiley-Blackwell, 2013)
      Many studies have observed altered neurofunctional and structural organization in the aging brain. These observations from functional neuroimaging studies show a shift in brain activity from the posterior to the anterior ...
    • Hockey Concussion Education Project, Part 1. Susceptibility-weighted imaging study in male and female ice hockey players over a single season 

      Helmer, Karl G.; Pasternak, Ofer; Fredman, Eli; Preciado, Ronny I.; Koerte, Inga Katharina; Sasaki, Takeshi; Mayinger, Michael; Johnson, Andrew M.; Holmes, Jeffrey D.; Forwell, Lorie A.; Skopelja, Elaine N.; Shenton, Martha Elizabeth; Echlin, Paul S. (Journal of Neurosurgery Publishing Group (JNSPG), 2014)
      Object—Concussion, or mild traumatic brain injury (mTBI), is a commonly occurring sports related injury, especially in contact sports such as hockey. Cerebral microbleeds (CMBs), which are small, hypointense lesions on ...
    • Hockey Concussion Education Project, Part 2. Microstructural white matter alterations in acutely concussed ice hockey players: a longitudinal free-water MRI study 

      Pasternak, Ofer; Koerte, Inga Katharina; Bouix, Sylvain; Fredman, Eli; Sasaki, Takeshi; Mayinger, Michael; Helmer, Karl G.; Johnson, Andrew M.; Holmes, Jeffrey D.; Forwell, Lorie A.; Skopelja, Elaine N.; Shenton, Martha Elizabeth; Echlin, Paul S. (Journal of Neurosurgery Publishing Group (JNSPG), 2014)
      Object—Concussion is a common injury in ice hockey and a health problem for the general population. Traumatic axonal injury has been associated with concussions (also referred to as mild traumatic brain injuries), yet the ...
    • Hockey Concussion Education Project, Part 3. White matter microstructure in ice hockey players with a history of concussion: a diffusion tensor imaging study 

      Sasaki, Takeshi; Pasternak, Ofer; Mayinger, Michael; Muehlmann, Marc; Savadjiev, Peter; Bouix, Sylvain; Kubicki, Marek R.; Fredman, Eli; Dahlben, Brian; Helmer, Karl G.; Johnson, Andrew M.; Holmes, Jeffrey D.; Forwell, Lorie A.; Skopelja, Elaine N.; Shenton, Martha Elizabeth; Echlin, Paul S.; Koerte, Inga Katharina (Journal of Neurosurgery Publishing Group (JNSPG), 2014)
      Object—The aim of this study was to examine the brain’s white matter microstructure using magnetic resonance diffusion tensor imaging (DTI) in ice hockey players with a history of clinically symptomatic concussion compared ...
    • Increased Gray Matter Diffusion Anisotropy in Patients with Persistent Post-Concussive Symptoms following Mild Traumatic Brain Injury 

      Bouix, Sylvain; Pasternak, Ofer; Rathi, Yogesh; Pelavin, Paula E.; Zafonte, Ross; Shenton, Martha E. (Public Library of Science, 2013)
      A significant percentage of individuals diagnosed with mild traumatic brain injury (mTBI) experience persistent post-concussive symptoms (PPCS). Little is known about the pathology of these symptoms and there is often no ...
    • Neuroimaging in repetitive brain trauma 

      Ng, Thomas SC; Lin, Alexander P; Koerte, Inga K; Pasternak, Ofer; Liao, Huijun; Merugumala, Sai; Bouix, Sylvain; Shenton, Martha E. (BioMed Central, 2014)
      Sports-related concussions are one of the major causes of mild traumatic brain injury. Although most patients recover completely within days to weeks, those who experience repetitive brain trauma (RBT) may be at risk for ...
    • Reconstruction of the arcuate fasciculus for surgical planning in the setting of peritumoral edema using two-tensor unscented Kalman filter tractography 

      Chen, Zhenrui; Tie, Yanmei; Olubiyi, Olutayo; Rigolo, Laura; Mehrtash, Alireza; Norton, Isaiah; Pasternak, Ofer; Rathi, Yogesh; Golby, Alexandra J.; O'Donnell, Lauren J. (Elsevier, 2015)
      Background: Diffusion imaging tractography is increasingly used to trace critical fiber tracts in brain tumor patients to reduce the risk of post-operative neurological deficit. However, the effects of peritumoral edema ...
    • A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury 

      Shenton, Martha Elizabeth; Hamoda, Hesham; Schneiderman, J. S.; Bouix, Sylvain; Pasternak, Ofer; Rathi, Yogesh; Vu, M.-A.; Purohit, Maulik Prafull; Helmer, Karl G.; Koerte, Inga Katharina; Lin, Alexander Peter; Westin, Carl-Fredrik; Kikinis, Ron; Kubicki, Marek R.; Stern, R. A.; Zafonte, Ross Dennis (Springer Science + Business Media, 2012)
      Mild traumatic brain injury (mTBI), also referred to as concussion, remains a controversial diagnosis because the brain often appears quite normal on conventional computed tomography (CT) and magnetic resonance imaging ...
    • The Sport Concussion Education Project. A brief report on an educational initiative: from concept to curriculum 

      Echlin, Paul S.; Johnson, Andrew M.; Holmes, Jeffrey D.; Tichenoff, Annalise; Gray, Sarah; Gatavackas, Heather; Walsh, Joanne; Middlebro, Tim; Blignaut, Angelique; MacIntyre, Martin; Anderson, Chris; Fredman, Eli; Mayinger, Michael; Skopelja, Elaine N.; Sasaki, Takeshi; Bouix, Sylvain; Pasternak, Ofer; Helmer, Karl G.; Koerte, Inga Katharina; Shenton, Martha Elizabeth; Forwell, Lorie A. (Journal of Neurosurgery Publishing Group (JNSPG), 2014)
      Current research on concussion is primarily focused on injury identification and treatment. Prevention initiatives are, however, important for reducing the incidence of brain injury. This report examines the development ...
    • White matter correlates of cognitive domains in normal aging with diffusion tensor imaging 

      Sasson, Efrat; Doniger, Glen M.; Pasternak, Ofer; Tarrasch, Ricardo; Assaf, Yaniv (Frontiers Media S.A., 2013)
      The ability to perform complex as well as simple cognitive tasks engages a network of brain regions that is mediated by the white matter fiber bundles connecting them. Different cognitive tasks employ distinctive white ...
    • Widespread white matter degeneration preceding the onset of dementia 

      Maier-Hein, Klaus H.; Westin, Carl-Fredrik; Shenton, Martha Elizabeth; Weiner, Michael W.; Raj, Ashish; Thomann, Philipp; Kikinis, Ron; Stieltjes, Bram; Pasternak, Ofer (Elsevier BV, 2015)
      Background—Brain atrophy in subjects with mild cognitive impairment (MCI) introduces partial volume effects, limiting the sensitivity of diffusion tensor imaging to white matter microstructural degeneration. Appropriate ...